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DCTN1 mutations were identified in a family with motor-neuron disease before the discovery in Perry syndrome.
ASK1 (Montrer MAP3K5 Protéines)- induced phosphorylation of EB1 (Montrer MAPRE2 Protéines) not only increases its plus end-tracking ability, but also promotes its recruitment of CLIP170 and p150glued to astral microtubules.
DCTN1 p.K56R in patients with PSP (Montrer MSMB Protéines).
Results suggested that variants in DCTN1 are not common risk factors for Chinese sporadic amyotrophic lateral sclerosis and that the frequency of variants of unknown significance in the cohort study was 0.39%.
This work reveals the structural details of Hook3 (Montrer HOOK3 Protéines)'s interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes.
No DCTN1 variants of disease significance were identified in this study suggesting the dynactin genes are unlikely to be a common cause of inherited peripheral neuropathies.
Mutations in the Dynactin 1 (DCTN1) gene have been demonstrated to result in various neurodegenerative diseases, including distal hereditary motor neuropathy type 7B. In the present study, a p.G59S mutation was identified as the underlying cause of Distal hereditary motor neuropathy type 7B in two families, and their detailed clinical features were characterized.
Study found that in peripheral blood mononuclear cells the median expression of KIFC3, KIF1B, and KIF5C (Montrer KIF5C Protéines) was much lower than the expression of dynactin subunits DCTN1 and DCTN3 (Montrer Dctn3 Protéines), in both sporadic amyotrophic lateral sclerosis and healthy cases
Data suggest that cargo concentration at ERES is regulated by p150(glued) to coordinate protein sorting and transport carrier formation with the subsequent long-range transport towards the Golgi complex along microtubules.
Study shows p150glued located at the centrosome in a cell cycle-dependent manner where it is abundant during G1/S phase, located in the minus-end of microtubules during G2/M phase and at the minus-end of microtubules in the mitotic phase.
our findings demonstrate that p150(Glued) is particularly required to maintain the function and survival of spinal motor neurons during aging
p75NTR (Montrer NGFR Protéines) intracellular domain as a retrograde degenerative signal and reveal p150(Glued) deacetylation as a unique mechanism regulating axonal transport
a mouse model expressing disease linked-G59S mutant dynactin p150(Glued) develops motor dysfunction >8 months before loss of motor neurons or dopaminergic degeneration is observed.
These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor.
Functional relationships between PIK3C3 (Montrer PIK3C3 Protéines), dynactin, and AnkB (Montrer ANKH Protéines) promote axonal transport of organelles and are required for normal axon length.
The direct binding of the dynactin subunit p150(Glued) to JIP1 (Montrer MAPK8IP1 Protéines) competitively inhibits KHC (Montrer KIF5A Protéines) activation in vitro and disrupts the transport of APP (Montrer APP Protéines) in neurons.
These data unveil a previously unrecognized role for the dynein-dynactin motor complex in osteoclast formation and function.
in addition to its ciliogenic roles, Kif3a (Montrer KIF3A Protéines) recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres.
Overexpression of TBCB leads to the decreased localization of p150 to the microtubule network that might result in a functional modulation of this protein complex.
Melanoregulin (Montrer MREG Protéines) interacts with the C-terminal domain of Rab-interacting lysosomal protein (RILP (Montrer RILP Protéines)) and forms a complex with RILP (Montrer RILP Protéines) and p150(Glued) (also known as dynactin subunit 1, DCTN1), a component of the dynein-dynactin motor complex.
Arfaptin (Montrer ARFIP1 Protéines) physically associates with Glued and other dynactin complex components in the nervous system of both flies and mice and colocalizes with Glued at the Golgi in motor neurons.
It uncovered an important requirement for Lis1 (Montrer PAFAH1B1 Protéines) in promoting the recruitment of dynein and its accessory complex dynactin to RNA localization complexes.
multiple independent disruptions of Dynactin function cause a relocation of the photoreceptor nucleus toward the brain
dynein-dynactin, abnormal spindle protein (Asp), and KLP10A have roles in Drosophila spindle pole organization
We conclude that Lis1 (Montrer PAFAH1B1 Protéines)/dynactin act together to regulate multiple, independent functions in mitotic cells, including spindle formation and cell cycle checkpoint release.
Microtubule binding depends on the N-terminal domain of p150[glued].
Mutants in the Lis1 (Montrer PAFAH1B1 Protéines)/dynactin complex strongly decrease maximum and average spindle velocity, consistent with this motor complex mediating spindle/cortex forces.
Dynein-dynactin plays a role in excluding dendritic Dscam (Montrer DSCAM Protéines) from axons by retrograde transport.
show that this cell polarity regulator interacts with Glued during central synapse formation.
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).
150 kDa dynein-associated polypeptide
, dynactin 1 (p150, glued homolog, Drosophila)
, dynactin subunit 1
, dynactin 1
, dynactin subunit 1-like
, dynactin 1, retrograde axonal transport
, dynactin P150
, dynactin 1 (p150, glued homolog)