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NDE1/Lissencephaly 1 and dynactin (Montrer DCTN1 Anticorps) complexes separately mediate two key components of T cell-focused secretion, namely translocation of the MTOC and lytic granules to the IS, respectively.
Results indicate that the NAGK (Montrer NAGK Anticorps)-dynein interaction with the involvements of Lis1 (Montrer PAFAH1B1 Anticorps) and NudE1 plays an important role in prophase nuclear envelope breakdown (NEB (Montrer NEB Anticorps)) and metaphase MT-KT attachment during eukaryotic cell division.
Promoter system of NDE1, which produces three distinct transcripts, each encoding for the same full-length NDE1 protein (also known as NudE), was cloned and tested in human cell lines; results highlight and clone the promoter elements required to generate systems in which the NDE1 protein is exogenously expressed under its native promoter, providing a biologically relevant model of 16p13.11 duplication in mental illness
Interaction between NDE1 and high birth weight was associated with increased susceptibility to schizophrenia.
study strengthens the evidence for association between rare variants within NDE1 and schizophrenia, and may shed light into the molecular mechanisms underlying this severe psychiatric disorder.
These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.
study provided comprehensive documentation of the expression patterns of Nde1 and Ndel1 (Montrer NDEL1 Anticorps) in cultured cells as well as in mouse and human brains, and also highlighting that dosage effects of these two proteins might contribute to some cases of mental disorder
Description of a severe microcephaly syndrome where an autosomal recessive condition combines an inherited segmental duplication mediated deletion with a mutation in the NDE1 gene within the non-deleted homolog.
In three related patients with microhydranencephaly, a homozygous deletion that encompasses NDE1 exon 2 containing the initiation codon was identified.
analysis of mixed NDE1-NDEL1 (Montrer NDEL1 Anticorps) complexes demonstrates that NDE1 and NDEL1 (Montrer NDEL1 Anticorps) can interact directly.
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants.
LIS1-interacting protein NUDE1, rat homolog
, nuclear distribution protein nudE homolog 1
, nudE nuclear distribution E homolog 1
, nudE nuclear distribution gene E homolog 1