Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Sélectionnez vos espèces et l'application
anti-Mouse (Murine) Anticorps:
anti-Rat (Rattus) Anticorps:
Vous arrivez à notre recherche pré-filtrée.
Human Polyclonal XPO1 Primary Antibody pour ICC, IF - ABIN256674
von Knethen, Tzieply, Jennewein, Brüne: Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol. dans Journal of cell science 2010
Show all 7 Pubmed References
Cow (Bovine) Polyclonal XPO1 Primary Antibody pour IHC, IHC (p) - ABIN4300538
Bagheri, Badduke, Qiao, Colnaghi, Abramowicz, Alcantara, Dunham, Wen, Wildin, Nowaczyk, Eichmeyer, Lehman, Maranda, Martell, Shan, Lewis, ODriscoll, Gregory-Evans, Rajcan-Separovic: Identifying candidate genes for 2p15p16.1 microdeletion syndrome using clinical, genomic, and functional analysis. dans JCI insight 2016
Human Polyclonal XPO1 Primary Antibody pour ICC, IF - ABIN4300539
Steyaert, Scheveneels, Vanneste, Van Damme, Robberecht, Callaerts, Bogaert, Van Den Bosch: FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins. dans Human molecular genetics 2019
Nucleoporin 154 and Exportin1 (XPO1) prevented FUS-induced neurotoxicity. Moreover, we show that XPO1 interacted with FUS. Silencing XPO1 significantly reduced the propensity of FUS to form inclusions upon stress.
two newly identified factors that restrict diverse viruses, dXPO1 and dRUVBL1 contributed to antiviral defense at the organismal level in adult flies
Nuclear export of TIS11 proteins is mediated by CRM1 through diverging nuclear export signals, while their nuclear import mechanism may rely on a highly conserved signal whose activity is negatively regulated by ZnF2 folding.
HPO promotes the translocation of SD to the cytoplasm in a CRM1-dependent manner
Exportin-1 is a nuclear export receptor for expanded polyQ containing proteins.
Nuclear localization of the ecdysteroid receptor (EcR) is increased in HeLa cells if exportin-1 (CRM1) is knocked down by siRNA against exportin.
Data show that downregulation of YAN involves CRM1-mediated nuclear export, and that MAE is involved in MAPK phosphorylationof YAN.
A major function of DNup88 is to anchor DNup214 and CRM1 on the nuclear envelope and thereby attenuate NES-mediated nuclear export.
Phosphorylation of Yan favors Crm1 in this competition and counteracts inhibition of nuclear export by Mae
two functional nuclear export signals are in the Sima basic helix-loop-helix (bHLH) domain and promote CRM1-dependent nuclear export
Study shows that CRM1 is involved in the nuclear-cytoplasmic shuttling of estrogen receptors in the androgen-independent prostate cancer cell line DU-145.
These results show that XPO1 inhibition synergizes with ABT-199 to induce apoptosis in acute myeloid leukaemia cell lines.
p53 does act downstream of selinexor and nutlin-3a, and that p53 expression is dispensable for selinexor to cause cell death, but nutlin-3a response is more p53-dependent.
Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias.
De novo produced TFIIA is rapidly confined to the cytoplasm via an evolutionary conserved nuclear export signal (NES, amino acids 21VINDVRDIFL30), interacting with the nuclear export receptor Exportin-1/chromosomal region maintenance 1 (Crm1).
XPO1 performs nuclear export of a signal transducer and activator of transcription 6 (STAT6) in HEK-293 and primary mediastinal B-cell lymphoma (PMBL) cell lines expressing either a wild-type or a mutated XPO1 protein.
Net1A relocalization stimulated by EGF or JNK activation requires nuclear export mediated by CRM1.
We have confirmed the essential role of XPO1 in cell proliferation and in growth transformation of Kaposi's sarcoma-associated herpesvirus-transformed cells, as well as of gastric and liver cancer cells.
Findings revealed that an epigenetic regulatory mechanism involving the regulation of Exportin 1 by microRNA-412, and the downstream p53-p66SHC-p16 pathway may play a role in vascular endothelial cell proliferation in hemorrhoid tissue and hemorrhoid formation.
The E571K XPO1 mutation was significantly correlated with several adverse prognostic factors such as age >/=45, advanced stage, high IPSS index, poor performance status, and abdominal involvement in 89 adult Hodgkin disease patients. No correlation between XPO1 mutation and outcome was found.
CRM-1 and CALR are upregulated in breast cancer cells, particularly those that are ERalpha-negative. In this context, the interaction between CRM-1 and CALR seems to modulate the nuclear export of nuclear receptors.
the relationship between nuclear export activities of 24 different nuclear export signal (NES) peptides in cells and their CRM1-NES affinities, is examined.
We describe three in vitro reconstituted disassembly intermediates, which show binding of a Crm1 export complex via two FG-repeat patches, cargo-release by RanBP2's Ran-binding domains and retention of free Crm1 at RanBP2 after Ran-GTP hydrolysis.
Nuclear entrapment of p33ING1b by inhibition of exportin-1 triggers apoptosis in head and neck squamous cell cancer cells.
CDK4 and XPO1 are not altered in a rare undifferentiated sarcoma, making them therapeutic targets
The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib.
this work advocates for assessing 2p+ and XPO1 mutations before choosing a chronic lymphocytic leukemia therapy.
Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.
We provide evidence for a regulatory role of CRM1 (chromosome-region-maintenance-1; also known as XPO1, exportin-1) in juxta-nuclear microtubule-dependent adenovirus transport. Leptomycin B (LMB) abolishes nuclear targeting of adenovirus. It binds to CRM1, precludes CRM1-cargo binding and blocks signal-dependent nuclear export.
in leukemia cell lines an XPO1 heterozygous mutation confers similar resistance against selinexor as homozygous substitution, demonstrating that SINE resistance can be obtained by a single and dominant mutation of the cysteine528 residue in XPO1
These results showed the presence of XPO1 and its function as a nuclear export receptor in mammalian oocytes, including growing oocytes, and they suggest that the regulation of nuclear transport has a large influence on the germinal vesical maintenance and meiotic resumption of oocytes.
CRM1 binds to Axin in the presence of RanGTP
These results suggest a differential interaction between human Crm1 and mouse Crm1 and many lentiviral Rev proteins, which may partially explain the HIV replicative defect in mice.
Data show that administration of a single dose of selinexor bound Exportin 1 (XPO1/CRM1) for minimally 72 hours both in vitro and in vivo.
These results suggest a model wherein HIV-1 Rev-associated nuclear export signals cooperate to regulate the number or quality of CRM1's interactions with viral Rev/RRE ribonucleoprotein complexes in the nucleus.
map the nuclear import and export signals of Dp71d by truncation and point mutant analysis, showing for the first time Dp71d shuttles between nucleus and cytoplasm mediated by conventional nuclear transporters, importin (IMP) alpha/beta and the exportin CRM1
AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1.
A CRM1-mediated nuclear export signal is essential for cytoplasmic localization of neurogenin 3 in neurons.
Bioavailable CRM1 inhibitor KPT-251 significantly inhibited renal cell carcinoma growth in vivo with the expected on target effects and no obvious toxicity.
CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells
CaMKI vies with CRM1/exportin 1 for access to a nuclear export signal, and assembly of a CaMKI-14-3-3 zeta-CCTalpha complex is a key effector mechanism that drives nuclear CCTalpha translocation.
Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism.
CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor
UAP56 and URH49 exhibit an intrinsic CRM1-independent nucleocytoplasmic shuttling
p53 subcellular localization resulting from CRM1 alterations may play an important role in lung tumorigenesis
These results clearly demonstrate that Nup98 functions as a novel shuttling cofactor for Crm1-mediated nuclear export in conjunction with RanBP3.
Crm1 inhibition promotes accumulation of p65 NF-kB in nuclei of poly(ADP-ribose) polymerase-1-deficient cells and reverses expression of NF-kappaB-dependent genes upon Toll-like receptor (TLR)4 stimulation.
results indicate that the minute virus of mice (MVMi) NS2-CRM1 interaction is an important determinant of MVMi virulence that can be modulated in nature
C-terminal sequences direct cyclin D1-CRM1 binding
NPM/B23 localizes between the paired centrioles of unduplicated centrosomes; inhibition of Crm1 nuclear export receptor results in both accumulation of cyclin E at centrosomes and efficient dissociation of NPM/B23 from centrosomes
Induction of differentiation in epidermal keratinocytes activates a specific program for post-transcriptional downregulation of E2F1, which involves signaling through p38 and activation of CRM1-dependent nuclear export
The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
, chromosomal region maintenance 1
, exportin 1
, exportin 1 (CRM1 homolog, yeast)
, exportin 1-like
, CRM1, yeast, homolog
, chromosome region maintenance 1 protein homolog
, exportin 1 (CRM1, yeast, homolog)
, exportin-1 (required for chromosome region maintenance)
, nuclear export factor CRM1
, CRM1/XPO1 protein