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anti-Human BUB3 Anticorps:
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Human Polyclonal BUB3 Primary Antibody pour ICC, ELISA - ABIN1001948
Kalitsis, Earle, Fowler, Choo: Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. dans Genes & development 2000
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Human Polyclonal BUB3 Primary Antibody pour WB - ABIN1981301
Morais da Silva, Moutinho-Santos, Sunkel: A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition. dans The Journal of cell biology 2013
Human Polyclonal BUB3 Primary Antibody pour ICC, ELISA - ABIN1887091
Jiang, Li, Yang, Hawke, Zheng, Xia, Aldape, Wei, Guo, Chen, Lu: PKM2 regulates chromosome segregation and mitosis progression of tumor cells. dans Molecular cell 2014
Human Polyclonal BUB3 Primary Antibody pour ICC, IF - ABIN4285582
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. dans Journal of proteomics 2012
Human Polyclonal BUB3 Primary Antibody pour IF, WB - ABIN541308
Roberts, Farr, Hoyt: The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. dans Molecular and cellular biology 1994
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Small sequence differences in Bub1 and BubR1 direct Bub3 to different phosphorylated targets in the spindle assembly checkpoint signaling cascade.
The integrity of the mitotic checkpoint complex depends on the specific recognition between BubR1 and Bub3, for which the BubR1 Gle2 binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 and BUB3 by BUB1 is dispensable for SAC activation
a mutual antagonism exists between Bub3 and dynein to ensure optimal KT-MT attachments
the mechanisms of BUB3 in mitotic checkpoint signaling
Data show sequential multisite regulation of the microtubule-associated protein KNL1-kinase-adaptor complex BUB1/BUB3 interaction.
Data indicate that cell cycle protein Bub3-mediated kinetochore recruitment of BubR1 kinase enhances mitotic checkpoint signaling.
Results suggest that these USP7-dependent effects are mediated by decreased levels of spindle assembly checkpoint (SAC) component Bub3.
Mutations targeting the Bub3 interface prevent kinetochore recruitment of the SAC kinase Bub1. Crucially, they also cause a checkpoint defect, showing that recognition of phosphorylated targets by Bub3 is required for checkpoint signaling
Results showed that neither variants in BUB3 nor variants in MAD2L1 caused any significant effect on the risk of breast cancer
Mutations in BUB1 and BUB3 cause mosaic variegated aneuploidy and increase the risk of colorectal cancer at a young age.
These results indicate that Bub3 and Cdc20 play additional roles in the integration of cell cycle arrest as transcriptional repressors.
Allelic loss at 10q26 in osteosarcoma is reported in the region of BUB3.
subpopulation of dynein, containing the DYNLT3 light chain, may be important for chromosome congression, in addition to having a role in the transport of checkpoint proteins from the kinetochore to the spindle pole
Using RNA interference and high-resolution microscopy, we analyzed kinetochore-microtubule attachments in Bub3-depleted cells and compared them to those in Bub1- or BubR1-depleted cells.
Results suggest a novel molecular mechanism leading to aneuploidy involving interference of TAp73alpha with Bub1 and Bub3 resulting in an altered mitotic checkpoint.
Data show that Zfp207 binds to Bub3 to form a complex and maintains its protein level in oocytes, and that overexpression of Bub3 is able to partially rescue the occurrence of aneuploid eggs in Zfp207-depleted oocytes.
as a member of the spindle assembly checkpoint, Bub3 is required for regulation of both meiosis I and II, and is potentially involved in kinetochore-microtubule attachment in mammalian oocytes
Cenpa, Cenpb, and Bub3, but not Cenpc, interacted with PARP-1
Haploinsufficiency of Bub3 causes a slight increase in chromosome instability but is not clearly associated with a noticeable rise in the probability of tumor formation.
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
BUB3 budding uninhibited by benzimidazoles 3 homolog
, budding uninhibited by benomyl
, budding uninhibited by benzimidazoles 3 homolog
, mitotic checkpoint component
, mitotic checkpoint protein BUB3
, WD repeat protein Bub3
, WD repeat type I transmembrane protein A72.5