anti-CASC5 Anticorps

Profil protéine

The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11\;15)(q23\;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.

Alternative names and synonyms associated with CASC5

• kinetochore scaffold 1 (KNL1) anticorps
• kinetochore scaffold 1 (Knl1) anticorps
• Kinetochore null protein 1 (knl-1) anticorps

• 2310043D08Rik anticorps
• 5730505K17Rik anticorps
• AF15Q14 anticorps
• CT29 anticorps
• D40 anticorps
• Afficher tous les alias de synonymes
• hKNL-1 anticorps
• hSpc105 anticorps
• KNL1 anticorps
• PPP1R55 anticorps
• Rad51 anticorps
• Spc7 anticorps

Protein level used designations for CASC5

cancer susceptibility candidate 5 , ALL1-fused gene from chromosome 15q14 protein , blinkin, bub-linking kinetochore protein , cancer susceptibility candidate gene 5 protein , cancer/testis antigen 29 , kinetochore null 1 homolog , kinetochore-null protein 1 , protein CASC5 , protein phosphatase 1, regulatory subunit 55 , RAD51 homolog