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Cerberus binds and inhibits Nodal, Activin B, BMP-6, and BMP-7 but not BMP-2 or Activin A.
No significant association between the studied DKK1 variations and osteoporosis was found, while CER1 variations seem to play a significant role in the determination of osteoporosis, combined with bone markers, in postmenopausal osteoporotic women.
results show that Cer1 (or CER1) serves as a good marker for quantification of definitive endoderm differentiation of mouse and human ES/iPS cells
CER1 gene variations play a significant role in determining BMD and vertebral or hip fractures, which might be helpful in clinical practice to identify patients with increased fracture risk
functional candidate gene for trigonocephaly
successful identification of an association with CER1 in humans together with our mouse study suggests that CER1 may play a role in the development of bone or its metabolism
Studies indicate that erberus prevents Nodal signaling in the anterior and right sides of the embryo.
Chordin, Noggin, beta-Catenin, and Cerberus have roles in neural induction in Xenopus
Cardiogenesis in mesoderm depends on Nodal-mediated induction of Cerberus in underlying endoderm.
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.
DAN domain family member 4
, cerberus 1, cysteine knot superfamily, homolog
, cerberus-related 1
, cerberus-related protein
, cerberus 1 homolog, cysteine knot superfamily
, cerberus 1, cysteine knot superfamily