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dtopors plays a structural role in spermatocyte lamina that is critical for multiple aspects of meiotic chromosome transmission
Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein
Data suggest a mechanism for the inhibitory effects of Sdc-1 (Montrer SDC1 Protéines) on cell growth that involves the interaction between the cytoplasmic domain of Sdc-1 (Montrer SDC1 Protéines) and the SUMO-1 (Montrer SUMO1 Protéines) E3 ligase, Topors.
These results indicate a unique role for Topors in the maintenance of genomic stability and pericentric heterochromatin, as well as in cellular sensitivity to histone deacetylase (Montrer HDAC1 Protéines) inhibitors.
NKX3.1 (Montrer NKX3-1 Protéines) can be ubiquitinated by TOPORS in vitro and in vivo, and overexpression of TOPORS leads to NKX3.1 (Montrer NKX3-1 Protéines) proteasomal degradation in prostate cancer cells
A novel mutation of the TOPORS gene was identified, c.2539C>T p.(Arg847Ter), resulting in a premature termination codon and suggesting haploinsufficiency as the pathological mechanism.
P26s4 (Montrer PSMC1 Protéines) Associates with the C-Terminal Region of TOPORS.
Data suggest that TOPORS plays key role in turnover of H2AX (Montrer H2AFX Protéines) (H2A histone family, member X protein) depending on the type of oxidative stress/DNA damage; TOPORS may act as an E3 ubiquitin ligase (Montrer MUL1 Protéines) for histones.
Disturbed flow induces peroxynitrite production and binding to the E3 SUMO (small ubiquitin-like modifier (Montrer SUMO1 Protéines)) ligase PIASy (Montrer PIAS4 Protéines) (protein inhibitor of activated STATy).
In photoreceptors, TOPORS localizes primarily to the basal bodies of connecting cilium and in the centrosomes.
Polo-like kinase 1 (Plk1)-associated phosphorylation of Topors at S718 is essential for nocodazole-induced degradation of Topors.
We present a novel mutation in the TOPORS gene co-segregating with a distinct phenotype of adPRD in a large Norwegian family.
Topors, a p53 (Montrer TP53 Protéines) and topoisomerase I (Montrer TOP1 Protéines) binding protein, interacts with the adeno (Montrer ADORA2A Protéines)-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression
topors localizes in punctate nuclear regions associated with PML (Montrer PML Protéines) protein nuclear bodies.
Multiple SUMO-1 (Montrer SUMO1 Protéines) modified forms of Topors could be detected after cotransfection of exogenous SUMO-1 (Montrer SUMO1 Protéines) and Topors induced the colocalization of a YFP tagged SUMO-1 (Montrer SUMO1 Protéines) protein in a speckled pattern in the nucleus.
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.
, topoisomerase I-interacting protein
, E3 ubiquitin-protein ligase Topors
, topoisomerase I binding, arginine/serine-rich
, E3 ubiquitin-protein ligase Topors-like
, e3 ubiquitin-protein ligase Topors-like
, SUMO1-protein E3 ligase Topors
, p53-binding protein 3
, topoisomerase 1-binding RING finger
, topoisomerase I-binding RING finger protein
, topoisomerase I-binding arginine/serine-rich protein
, tumor suppressor p53-binding protein 3