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Human Polyclonal CDC7 Primary Antibody pour WB - ABIN1882165
Sato, Arai, Masai: Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. dans The EMBO journal 1997
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Human Monoclonal CDC7 Primary Antibody pour ICC, IF - ABIN265783
Hubbi, Kshitiz, Gilkes, Rey, Wong, Luo, Kim, Dang, Levchenko, Semenza: A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. dans Science signaling 2013
Human Polyclonal CDC7 Primary Antibody pour IHC (p) - ABIN4296982
Kitamura, Fukatsu, Kakusho, Cho, Taniyama, Yamazaki, Toh, Yanagi, Arai, Chang, Masai: Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition. dans The Journal of biological chemistry 2011
Both CDC7 and DBF4 (Montrer DBF4 Anticorps) promoters bind E2F (Montrer E2F1 Anticorps), suggesting that increased E2F (Montrer E2F1 Anticorps) activity in RB1 (Montrer RB1 Anticorps) mutant cancers promotes increased DDK expression. Surprisingly, increased DDK expression levels are also correlated with both increased chemoresistance and genome-wide mutation frequencies.
p53 (Montrer TP53 Anticorps)-dependent control of CDC7 levels is essential for blocking G1/S cell-cycle transition upon genotoxic stress.
we propose that phosphorylation of TOP2A (Montrer TOP2A Anticorps) by CDC7/DBF4 (Montrer DBF4 Anticorps) in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A (Montrer TOP2A Anticorps) function could be relevant to prevent premature separation of centromeric DNA.
The data support a model where Cdc7 (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 and PP1a (Montrer PPP1CA Anticorps)/Cdk1 (Montrer CDK1 Anticorps) to the regulation of once-per-cell cycle DNA replication in mammalian cells.
Our data show that Cdc7 is highly expressed in colorectal cancer
The presence of the index SNP rs1192415 (TGFBR3 (Montrer TGFBR3 Anticorps)-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients.
MiR (Montrer MLXIP Anticorps)-630 promoted apoptosis by downregulation of CDC7.
The state of DUE-B phosphorylation is maintained by the equilibrium between Cdc7-dependent phosphorylation and PP2A (Montrer PPP2R4 Anticorps)-dependent dephosphorylation.
The interaction between Claspin (Montrer CLSPN Anticorps) and Cdc7 is not dependent on Cdc7 kinase activity, but Claspin (Montrer CLSPN Anticorps) interaction with the DNA helicase subunit Mcm2 (Montrer MCM2 Anticorps) is lost upon Cdc7 inhibition.
huCdc7 may play an important role in the development and progression of colorectal cancer.
Cdc7 physically and functionally interacts with Nkx2.5 (Montrer NKX2-5 Anticorps) to regulate Myocd (Montrer MYOCD Anticorps) promoter activity
Cdc7 mediates SMC (Montrer DYM Anticorps) differentiation through a mechanism distinct from cell proliferation.
MCM4 (Montrer MCM4 Anticorps) phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 (Montrer CDC45 Anticorps) on chromatin
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.
cell division cycle 7-related protein kinase
, CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
, CDC7-related kinase
, cell division cycle 7 homolog
, cell division cycle 7-like protein 1
, cell division cycle 7-like 1