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anti-Human DYRK1A Anticorps:
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Human Monoclonal DYRK1A Primary Antibody pour ELISA, WB - ABIN560675
Aranda, Alvarez, Turró, Laguna, de la Luna: Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. dans Molecular and cellular biology 2008
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Human Polyclonal DYRK1A Primary Antibody pour WB - ABIN1881275
Park, Oh, Yoo, Jung, Song, Lee, Seo, Chung: Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. dans The Journal of biological chemistry 2010
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LncRNA OIP5 (Montrer OIP5 Anticorps)-AS1 (Montrer PTGDR Anticorps) suppressed cell viability, promoted radio-induced apoptosis, and enhanced the radiosensitivity of CRC (Montrer CALR Anticorps) cells by regulating DYRK1A expression through miR (Montrer MLXIP Anticorps)-369-3p.
The authors show here that chemical inhibition or genetic knockdown of DYRK1A interferes with neural specification of human pluripotent stem cells, a process equating to the earliest stage of human brain development. Specifically, DYRK1A inhibition insulates the self-renewing subpopulation of human pluripotent stem cells from powerful signals that drive neural induction.
These results indicate a functional deficiency of DYRK1A as an underlying disease mechanism for autism.
Inhibition of DYRK1A resulted in an increased apoptosis and decrease in invasion and colony formation ability of HNSCC cell lines.
Immunoprecipitation and pulldown experiments identified DCAF7 (Montrer DCAF7 Anticorps) as an adaptor for the association of the adenovirus E1A (Montrer BCKDHA Anticorps) protein with DYRK1A and HIPK2 (Montrer HIPK2 Anticorps)
Results associate a decreased level of DYRK1A with Alzheimer's disease and challenge the use of DYRK1A inhibitors in peripheral tissues as treatment.
The locations of disruptive variants (truncating, missense, and splice site mutations), copy number variations, and chromosomal rearrangements affecting DYRK1A functions. DYRK1A is one of the most recurrent genes with disruptive single nucleotide variants implicated in Autism spectrum disorder.
we suggest that de novo dominant mutations in DYRK1A account for nearly 0.5% of severe developmental disorders due to substantially reduced kinase function
The data described herein provide the first identification of a DYRK1A-mediated site of phosphorylation on GLI1 (Montrer GLI1 Anticorps) within its NLS (Montrer ALDH1A2 Anticorps) and may serve as a valuable mechanism for further understanding Hh signaling modulation.
DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.
Chronic Dyrk1 inhibition reversed cognitive deficits in Alzheimer's disease transgenic mice via reduction of APP (Montrer APP Anticorps) and phosphorylated tau pathology.
Normalizing Dyrk1A gene dosage in Ts65Dn mouse rescued the density of senescent cells in cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced APP (Montrer APP Anticorps) expression in hippocampus, Abeta (Montrer APP Anticorps) load in cortex and hippocampus, expression of phosphorylated tau at the Ser202 residue in hippocampus and cerebellum, and levels of total tau in the cortex, hippocampus and cerebellum.
Depleting Huntingtin-associated protein 1 (Hap1 (Montrer HAP1 Anticorps)) promoted the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A)-DDB1 and CUL4 associated factor 7 (Dcaf7 (Montrer DCAF7 Anticorps)) interaction and increased the DYRK1A protein level.
Down-regulation of Dyrk1A returned returned phosphatidylcholine (Montrer SGMS2 Anticorps) in trisomic cells to original levels.
Taken together, these results strongly suggested that DYRK1A bound to CDKL5 (Montrer CDKL5 Anticorps) and phosphorylated it on Ser (Montrer SIGLEC1 Anticorps)-308, thus interfering with its nuclear localization.
Identify Dyrk1a as a novel negative regulator of D-cyclin (Montrer PCNA Anticorps)-mediated Rb1 (Montrer RB1 Anticorps)/E2f (Montrer E2F1 Anticorps)-signalling. As dysregulation of this pathway with impaired cardiomyocyte proliferation leads to cardiomyopathy.
study identifies DYRK1A-STAT (Montrer STAT1 Anticorps) as a signaling pathway responsible for the differentiation of neural progenitors into astrocytes, with direct implication for the anomalies in brain development observed in Down syndrome
This study identified decreased neuronal firing rate and deficits in gamma frequency in the prefrontal cortices of transgenic mice overexpressing Dyrk1A.
Increased Dyrk1a gene dosage is a major contributing factor to the abnormal appendicular skeletal phenotype observed in adolescent Ts65Dn Down syndrome mice.
the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.
Dyrk1A positively and selectively modulates p120-catenin (Montrer CTNND1 Anticorps) protein levels, thus having an impact on p120-catenin (Montrer CTNND1 Anticorps) and Kaiso (Montrer ZBTB33 Anticorps) (and canonical Wnt (Montrer WNT2 Anticorps)) gene targets such as siamois and wnt11.
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
, dual specificity tyrosine-phosphorylation-regulated kinase 1A
, protein kinase minibrain homolog
, dual specificity tyrosine-phosphorylation-regulated kinase 1A-like
, MNB/DYRK protein kinase
, dual specificity YAK1-related kinase
, mnb protein kinase homolog hp86
, serine/threonine kinase MNB
, serine/threonine-specific protein kinase
, Dual Specificity Yak1-related kinase
, minibrain protein kinase
, Protein kinase minibrain homolog