Profil protéine

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with MCM8

• minichromosome maintenance 8 homologous recombination repair factor (MCM8) anticorps
• minichromosome maintenance 8 homologous recombination repair factor (Mcm8) anticorps
• minichromosome maintenance 8 homologous recombination repair factor L homeolog (mcm8.L) anticorps

• 5730432L01Rik anticorps
• C20orf154 anticorps
• dJ967N21.5 anticorps

Protein level used designations for MCM8

DNA helicase MCM8 , DNA replication licensing factor MCM8 , MCM8 minichromosome maintenance deficient 8 , REC homolog , minichromosome maintenance 8 , minichromosome maintenance deficient 8 , Minichromosome maintenance 8