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Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr (Montrer INSR Kits ELISA)); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a). Inheritance of either allele results in insulin (Montrer INS Kits ELISA) resistance but not overt diabetes. Double heterozygosity leads to insulin (Montrer INS Kits ELISA) resistance and diabetes type 2 without increase in body weight.
Concurrent mTORC1 inactivation and PP2A-B55alpha stimulation fuel ULK1 (Montrer ULK1 Kits ELISA)-dependent autophagy.
FBXL16 (Montrer FBXL16 Kits ELISA) negatively regulates the activity of B55alpha-PP2A to modulate the genesis of FLK1 (Montrer KDR Kits ELISA)+ progenitor cells.
Ppp2r2a is required for Connexin-43 (Montrer GJA1 Kits ELISA) dephosphorlyation during epidermal barrier acquisition
The B55alpha-EDD-p53 pathway is essential for cancer cell survival and tumor growth under low glutamine conditions in vitro and in vivo.
that B55alpha-dependent targeting of the PP2A holoenzyme to Akt (Montrer AKT1 Kits ELISA) selectively regulates Akt (Montrer AKT1 Kits ELISA) phosphorylation at Thr (Montrer TRH Kits ELISA)-308 to regulate cell proliferation and survival.
PP-2A is less abundant than PP-1 (Montrer PPP1CC PLURAL_@12788@) in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
results suggest that PR55alpha promotes pancreatic cancer development by sustaining hyperactivity of multiple oncogenic signaling pathways, including AKT (Montrer AKT1 Kits ELISA), ERK (Montrer EPHB2 Kits ELISA), and Wnt (Montrer WNT2 Kits ELISA)
miR-222 targets protein phosphatase 2A subunit B in bladder cancer cells.
miR (Montrer MLXIP Kits ELISA)-556-5p functions as an onco-miRNA and participates in prostate cancer carcinogenesis by suppressing PPP2R2A expression.
Concurrent mTORC1 inactivation and PP2A (Montrer PPP2R4 Kits ELISA)-B55alpha stimulation fuel ULK1 (Montrer ULK1 Kits ELISA)-dependent autophagy.
Data show that breast cancer (BC) with PPP2R2A deletions are associated with worse overall survival, and the combination of altered PPP2R2A and high CCND1 (Montrer CCND1 Kits ELISA) expression define a subgroup of luminal-like BC patients with a high risk of relapse and death.
overexpression of miR (Montrer MLXIP Kits ELISA)-892a may provide a selective growth promotion for colorectal cancer cells by direct suppression of PPP2R2A expression.
miR (Montrer MLXIP Kits ELISA)-136 may play an important role during TGF-beta1 (Montrer TGFB1 Kits ELISA)-induced proliferation arrest by targeting PPP2R2A in keratinocytes.
Data suggest livers of biliary atresia subjects exhibit overexpression of MIR222 (microRNA 222); this appears to contribute to liver fibrosis (and in vitro cell proliferation) by targeting PPP2R2A (protein phosphatase 2A subunit B) and Akt (Montrer AKT1 Kits ELISA) signaling.
The suppression of B55alpha activates signaling pathways that could support leukemia cell survival.
Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A: Implications for PP2A
Phosphorylation of T231 (AT180) can negatively influence the dephosphorylation of the pS202/pT205 AT8 epitope, even without an altered PP2A pool.
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described.
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform
, serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform
, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
, PP2A subunit B isoform B55-alpha
, PP2A subunit B isoform BRA
, PP2A subunit B isoform PR55-alpha
, PP2A subunit B isoform R2-alpha
, PP2A subunit B isoform alpha
, PP2A, subunit B, B-alpha isoform
, PP2A, subunit B, B55-alpha isoform
, PP2A, subunit B, BRA isoform
, PP2A, subunit B, PR55-alpha isoform
, PP2A, subunit B, R2-alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform
, protein phosphatase 2A 55 kDa regulatory subunit, alpha isoform
, protein phosphatase 2, regulatory subunit B, alpha