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rs12901682 is associated with lung cancer risk in a Chinese Han population.
study concludes polymorphisms of TGM5 (Montrer TGM5 Protéines), PPAP2B (Montrer PPAP2B Protéines) and PSMA4 are not major contributors tonon-small cell lung cancer susceptibility in never-smoking hinese population, this primarily can be attributed to the significantly distinct genetic background of Asian populations from western populations
Parkin (Montrer PARK2 Protéines) interacts with the proteasome subunit alpha4
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
proteasome subunit alpha type-4
, proteasome alpha 4 subunit
, proteasome subunit C9-like protein
, proteasome subunit alpha type 4
, macropain subunit C9
, multicatalytic endopeptidase complex subunit C9
, proteasome component C9
, proteasome subunit L
, multicatalytic proteinase subunit L
, proteasome subunit HC9