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The role of the ubiquitin-proteasome system in pressure overloaded hearts andheart failure.
Probeta5 predominantly promotes integration into LMP2 (Montrer PSMB9 Protéines)/MECL-1 (Montrer PSMB10 Protéines)-containing precursors in IFNgamma-stimulated, LMP7 (Montrer PSMB8 Protéines)-deficient cells and infected LMP7 (Montrer PSMB8 Protéines)-deficient mice.
Data demonstrate that TNF-alpha (Montrer TNF Protéines) expression is primarily dependent on both the chymotrypsin-and the trypsin-like activities of X, Y, Z subunits (PSMB5, PSMB6 (Montrer PSMB6 Protéines), PSMB7 (Montrer PSMB7 Protéines)) of the proteasome.
Results identified PSMB5 Q62P mutation to underlie bortezomib resistance in Down-syndrome-associated acute myeloid leukemia (Montrer BCL11A Protéines) cells.
We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 (Montrer SLC12A2 Protéines) rs17764730, PSMB5 rs941718), and hematocrit (PROX1 (Montrer PROX1 Protéines) rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant
Data indicate that proteasomal subunit X PSMB5 is a target of signal transducer and activator of transcription 3 (STAT3 (Montrer STAT3 Protéines)).
Nuclear MB1 expression was an independent predictor of worse survival in ovarian cancer.
critical role of PSMB5 in 20S proteasome (Montrer PSMA5 Protéines)-mediated protection against replicative senescence, pointing to a possible strategy for maintaining the integrity of culture-expanded bone marrow stromal cells by manipulating the expression of PSMB5
Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1 (Montrer PSMB1 Protéines), PSMB5, PSMB6 (Montrer PSMB6 Protéines), PSMB8 (Montrer PSMB8 Protéines), PSMB9 (Montrer PSMB9 Protéines), and PSMB10 (Montrer PSMB10 Protéines).
Letter/Case Reports: proteasome subunit beta5t is expressed in cervical ectopic thymoma.
PSMB5 overexpression is associated with Bortezomib resistance in myeloma.
No mutations or differences in PSMB5 mRNA expression were seen before bortezomib treatment in 3 multiple myeloma patients, but after treatment, 1 patient showed PSMB5 upregulation associated with bortezomib resistance.
CDK5 (Montrer CDK5 Protéines) regulation of proteasome subunit PSMB5 was identified as a probable route to antineoplastic drug sensitization.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene.
proteasome subunit beta type 5
, proteasome subunit beta type-5
, proteasome (prosome, macropain) subunit, beta type, 5
, macropain epsilon chain
, multicatalytic endopeptidase complex epsilon chain
, proteasome beta type subunit 5
, proteasome chain 6
, proteasome epsilon chain
, proteasome subunit X
, proteasome beta 5 subunit
, PSX large multifunctional protease X
, proteasome catalytic subunit 3
, proteasome subunit MB1
, proteasome subunit, beta type, 5
, macropain chain 1
, multicatalytic endopeptidase complex chain 1
, proteasome C1 subunit
, proteasome chain 1
, proteasome subunit C1