Profil protéine

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4)

• 26S protease regulatory subunit 6B (LOC732870) anticorps
• regulatory particle, ATPase-like-3 (rpt-3) anticorps
• 26S protease regulatory subunit 6B (ATEG_04674) anticorps
• 26S protease regulatory subunit 6B (LELG_01296) anticorps
• 26S protease regulatory subunit 6B (HCAG_00039) anticorps
• Afficher tous les noms de gènes
• 26S proteasome regulatory subunit 6B (LOC5568998) anticorps
• 26S protease regulatory subunit 6B (GL50803_7950) anticorps
• 26S protease regulatory subunit 6B (EDI_044950) anticorps
• 26S protease regulatory subunit 6B (AOR_1_1218154) anticorps
• 26S protease regulatory subunit 6B (PTRG_03339) anticorps
• 26S protease regulatory subunit 6B (psmC4) anticorps
• 26S protease regulatory subunit 6B (prs6b) anticorps
• 26S protease regulatory subunit 6B (LOC100381342) anticorps
• proteasome 26S subunit, ATPase 4 (psmc4) anticorps
• proteasome 26S subunit, ATPase 4 (PSMC4) anticorps
• proteasome (prosome, macropain) 26S subunit, ATPase, 4 (Psmc4) anticorps
• proteasome 26S subunit, ATPase 4 (Psmc4) anticorps

• AO090003000692 anticorps
• CIP21 anticorps
• DDBDRAFT_0188209 anticorps
• DDBDRAFT_0191435 anticorps
• DDB_0188209 anticorps
• Afficher tous les alias de synonymes
• DDB_0191435 anticorps
• MIP224 anticorps
• NCU02260.1 anticorps
• RPT3 anticorps
• S6 anticorps
• TBP-7 anticorps
• Tbp7 anticorps

Protein level used designations for PSMC4

26S protease regulatory subunit 6B , 26S protease regulatory subunit 6b , 26S proteasome subunit ATPase 4 , HIV TAT binding-protein-related , 26S proteasome regulatory complex ATPase RPT3 , GRMZM2G090904 , 26S proteasome AAA-ATPase subunit RPT3 , MB67-interacting protein , Tat-binding protein 7 , protease 26S subunit 6 , CAR interacing protein 21 , CAR interacting protein 21 , TAT-binding protein 7 , TBP-7 , proteasome 26S ATPase subunit 4 , proteasome 26S subunit ATPase 4 , S6 ATPase