Profil protéine

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PSMC5

• protease (prosome, macropain) 26S subunit, ATPase 5 (Psmc5) anticorps
• proteasome 26S subunit, ATPase 5 (PSMC5) anticorps
• proteasome 26S subunit, ATPase 5 (psmc5) anticorps
• proteasome 26S subunit, ATPase 5 L homeolog (psmc5.L) anticorps
• proteasome 26S subunit, ATPase 5 (Psmc5) anticorps
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• proteasome 26S subunit, ATPase 5 S homeolog (psmc5.S) anticorps

• mSUG1 anticorps
• p45 anticorps
• p45/SUG anticorps
• PSMC5 anticorps
• S8 anticorps
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• sug-1 anticorps
• Sug1 anticorps
• tbp10 anticorps
• TRIP1 anticorps
• wu:fa14g03 anticorps
• wu:fb23a11 anticorps
• xsug1 anticorps
• zgc:92464 anticorps

Protein level used designations for PSMC5

26S protease regulatory subunit 8 , 26S proteasome AAA-ATPase subunit RPT6 , p45/SUG , proteasome 26S subunit ATPase 5 , proteasome subunit p45 , MSUG1 protein , Tat-binding protein homolog 10 , proteasome 26S ATPase subunit 5 , thyroid hormone receptor-interacting protein 1 , thyroid receptor interactor 1 , TRIP1 , for proteasomal ATPase (SUG1) , peptidase (prosome, macropain) 26S subunit, ATPase 5 , protease (prosome, macropain) 26S subunit, ATPase 5 , proteasomal ATPase (SUG1) , proteasome p45/SUG , 26S protease subunit , TAT-binding protein homolog 10 , SUG1 homolog