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RPN13 binds ubiquitin with an affinity similar to that of other proteasome-associated ubiquitin receptors and that RPN2, ubiquitin, and the deubiquitylase UCH37 bind to RPN13 with independent energetics.
Together, our findings suggest that the interaction of Psmd1 with Adrm1 is controlled by SUMOylation in a manner that may alter proteasome composition and function.
Increased 26S proteasome non-ATPase regulatory subunit 1 in the aqueous humor of patients with age-related macular degeneration compared to control subjects.
The 26S proteasome plays a key role in promoting apoptosis induced by high doses of UV irradiation.
p38 MAPK negatively regulates the proteasome activity by phosphorylating Thr-273 of Rpn2
neurotoxic products of inflammation, such as PGJ2, may play a role in neurodegenerative disorders by impairing 26 S proteasome activity and inducing a chain of events that culminates in neuronal cell death
analysis of how subunit radial displacements open the gate into the proteolytic core in the human 26S proteasome
Individual proteasome subunits are important for the regulation of age-related changes in both proteasome activity and protein oxidation.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.
26S proteasome non-ATPase regulatory subunit 1
, 26S proteasome regulatory subunit RPN2
, 26S proteasome regulatory subunit S1
, 26S proteasome subunit p112
, 26S proteasome p112 subunit
, 26S proteasome, subunit p112
, proteasome 26S non-ATPase subunit 1
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
, proteasome 26S subunit, non-ATPase 1 L homeolog