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Human PSMD3 Protein expressed in Wheat germ - ABIN1316635
Wei, Williams, Dang, Darden, Betz, Humble, Chang, Trempus, Johnson, Cannon, Tennant: Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation. dans Journal of molecular biology 2008
In thyroid hemiagenesis, genomic examinations revealed the presence of four recurrent defects (three deletions and one duplication) affecting highly conservative proteasome genes PSMA1 (Montrer PSMA1 Protéines), PSMA3 (Montrer PSMA3 Protéines), and PSMD3.
this study shows that haplotypes consisting of single nucleotide polymorphisms harboring PSMD3, CSF3 (Montrer CSF3 Protéines) and MED24 (Montrer MED22 Protéines) genes are associated with asthma in Slovenian patients
A strong association between genetic variant rs2305482 in PSMD3 on chromosome 17 and IFN-induced neutropenia.
HNF1A (Montrer HNF1A Protéines) gene was associated with C-reactive protein (Montrer CRP Protéines), and the region including PSMD3 and CSF3 (Montrer CSF3 Protéines) genes was associated with white blood cell count.
Our study suggests that PSMD3 variants are associated with insulin (Montrer INS Protéines) resistance in populations of different ancestries and that these relationships may also be modified by dietary factors.
Study identified significantly white blood cell count (WBC) level associated SNPs of three separate genes GSDMA (Montrer GSDMA Protéines), MED24 (Montrer MED22 Protéines), and PSMD3 in European continent (EA) subjects.
The significant contribution of PSMD3-CSF3 (Montrer CSF3 Protéines) and PLCB4 (Montrer PLCb4 Protéines) loci to the regulation of neutrophil count, is demonstrated.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count.
26S proteasome non-ATPase regulatory subunit 3
, 26S proteasome regulatory subunit RPN3
, 26S proteasome regulatory subunit S3
, proteasome subunit p58
, tissue specific transplantation antigen 2
, tissue specific transplantation antigen P91A
, transplantation antigen P91A
, tum-P91A antigen
, proteasome 26S non-ATPase subunit 3