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Aperçu des produits pour anti-Carboxylesterase 1 (CES1) Anticorps

Full name:: anti-Carboxylesterase 1 Anticorps (CES1)

Chez www.anticorps-enligne.fr sont 80 Carboxylesterase 1 (CES1) Anticorps de 23 de différents fournisseurs disponibles. De plus, nous expédions Carboxylesterase 1 Kits (18) et Carboxylesterase 1 Protéines (14) et beaucoup plus de produits pour cette protéine. Un total de 122 Carboxylesterase 1 produits sont actuellement listés.

Synonymes:: ACAT, APLE, CE-1, CEH, CES, CES-K1, CES1, CES2, CESDD1, hCE-1, HMSE, HMSE1, PCE-1, PMPMEase, REH, SES1, TGH

afficher tous les anticorps	Gène	GeneID	UniProt
	CES1	1066	P23141
	CES1
	CES1
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Pathways pertinentes pour anti-Carboxylesterase 1 Anticorps

Monocarboxylic Acid Catabolic Process

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Human Polyclonal CES1 Primary Antibody pour IHC (p), ELISA - ABIN548167 : Steinberg, Kemp, Watt: Adipocyte triglyceride lipase expression in human obesity. dans American journal of physiology. Endocrinology and metabolism 2007 (PubMed)

Plus d’anticorps contre Carboxylesterase 1 partenaires d’interaction

Human Carboxylesterase 1 (CES1) interaction partners

The results showed that there was a significant association between CES1 S75N (rs2307240) and the outcome of clopidogrel therapy. Moreover, the frequency of the T allele of rs2307240 in acute coronary syndrome patients (MAF = 0.22) was more than four times higher than that in the general public
Study utilized humanized mouse model expressing WT (control), G143E and catalytically dead S221A variants of human CES1 in the liver in the absence of endogenous expression of the mouse orthologous gene shows that compared to wild-type CES1, expression of the CES1G143E confers resistance to development of high-fat diet induced hepatic steatosis and leads to improved metabolic profile.
Which selectively amplified CES1A1 and, if present, also CES1A2.
These results are consistent with a model in which abrogation of CES1 function attenuates the CYP27A1-LXRalpha-ABCA1 signaling axis by depleting endogenous ligands for the nuclear receptors PPARgamma, RAR, and/or RXR that regulate cholesterol homeostasis.
Anordrin is predominantly catalyzed by CES1 and CES2 to generate the main active metabolite, anordiol.
genetic association and pharmacogenomic studies in population in Finland: Data suggest that 2 SNPs in CES1 (rs12443580, rs8192935) are associated with variations in expression of CES1 (in whole blood samples but not in liver); these CES1 SNPs do not affect pharmacokinetics or pharmacodynamics of clopidogrel, an inhibitor of platelet aggregation. A missense mutation in CES1 (rs71647871) impairs hydrolysis of clopidogrel.
The frequencies of SNVs with a potential functional impact were below 0.02 suggesting limited pharmacogenetic potential for CES1 genotyping.
none of the selected variations of CES1 had a clinically relevant impact on the metabolism of enalapril
Study revealed that several nsSNPs significantly impaired CES1 activity on the metabolism of the CES1 substrates enalapril, clopidogrel, and sacubitril.
Suggest a primary metabolic role for CES1 in the capacity of skin/keratinocytes to mediated biotransformation of penta-ethyl ester prodrug of DTPA.
These data suggest that infants younger than 3 weeks of age would exhibit significantly lower CES1- and CES2-dependent metabolic clearance compared with older individuals.
The intestinal transport of oseltamivir, a hCE1 substrate, could be evaluated in subclone #78 cell monolayers.
An association was identified with a genetic variation in CES1 and early-onset capecitabine-related toxicity.
Reduced CES1 expression/activity could promote development of METH-PAH.
These data suggest that CES1 genetic variants and gender are important contributing factors to variability in dabigatran etexilate activation in humans.
some functional CES1 genetic variants (for example, G143E) may impair ACE inhibitor activation, and consequently affect therapeutic outcomes of ACEI prodrugs.
HNF4alpha regulated CES1 expression by directly binding to the proximal promoter of CES1.
We conclude that the -816A>C variant is not associated with interindividual variability in CES1 expression and activity or therapeutic response to ACEI prodrugs
Our study identified CYP2C19*3 and CES1 rs8192950 as genetic polymorphisms related to recurrent ischemic events in patients with extracranial or intracranial occlusive disease, demonstrating the important roles of CYP2C19 and CES1 in patients treated with clopidogrel
Data suggest oseltamivir activation is associated with an SNP in CES1 (rs71647871, G143E); in liver from donors with genotype 143G/E activation is 40% of that from donors with genotype 143G/G. Hepatic CES1 expression in females is 17.3% higher than in males; oseltamivir activation rate in females is 27.8% higher than in males. (Liver tissues used were obtained from tissue banks located in the United States.)

Pig (Porcine) Carboxylesterase 1 (CES1) interaction partners

Data suggest that substrate specificity of porcine liver esterase extends to the plasticizers di-(2-ethylhexyl) trimellitates.
One novel isoform termed alternative pig liver esterase (APLE) was found to hydrolyze methyl-(2R,4E)-5-chloro-2-isopropyl-4-pentenoate in a highly stereoselective manner (E>200).
The objective of this study is to explore the mechanisms that regulate TGH expression in porcine adipocyte and its role in fasting-induced and Isoproterenol-stimulated lipolysis in porcine primary adipocytes.
Carboxylesterase distribution in minipig skin in similar to that in human skin.
PMPMEase was purified to apparent homogeneity from porcine liver supernatant.

Carboxylesterase 1 (CES1) profil antigène

Antigen Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.

Alternative names and synonyms associated with Carboxylesterase 1 (CES1)

carboxylesterase 1 (CES1) anticorps
liver carboxylesterase 1 (CpipJ_CPIJ013026) anticorps
liver carboxylesterase 1 (CpipJ_CPIJ016339) anticorps
liver carboxylesterase (LOC100009551) anticorps
liver carboxylesterase 1 (LOC454097) anticorps
liver carboxylesterase 1 (LOC699486) anticorps
liver carboxylesterase 1 (CES1) anticorps
carboxylesterase 1 (monocyte/macrophage serine esterase 1) (CES1) anticorps
liver carboxylesterase 1 (LOC100050915) anticorps

ACAT anticorps
APLE anticorps
CE-1 anticorps
CEH anticorps
CES anticorps
CES-K1 anticorps
CES1 anticorps
CES2 anticorps
CESDD1 anticorps
hCE-1 anticorps
HMSE anticorps
HMSE1 anticorps
PCE-1 anticorps
PMPMEase anticorps
REH anticorps
SES1 anticorps
TGH anticorps

Protein level used designations for CES1

, , , , , , , , , , , , , , , , , , , , acyl coenzyme A:cholesterol acyltransferase acyl-coenzyme A:cholesterol acyltransferase brain carboxylesterase hBr1 carboxylesterase 1 (monocyte/macrophage serine esterase 1) carboxylesterase 2 (liver) cholesteryl ester hydrolase cocaine carboxylesterase egasyn human monocyte/macrophage serine esterase 1 liver carboxylesterase 1 methylumbelliferyl-acetate deacetylase 1 monocyte/macrophage serine esterase retinyl ester hydrolase serine esterase 1 triacylglycerol hydrolase carboxylesterase D1 carboxylesterase 1 alternative pig liver esterase liver carboxylesterase prenylated methylated protein methyl esterase proline-beta-naphthylamidase

GENE ID	SPECIES
1066	Homo sapiens
6045866	Culex quinquefasciatus
6050034	Culex quinquefasciatus
100009551	Oryctolagus cuniculus
403643	Canis lupus familiaris
454097	Pan troglodytes
493774	Felis catus
699486	Macaca mulatta
100144615	Monodelphis domestica
397478	Sus scrofa
512098	Bos taurus
100050915	Equus caballus
102129184	Macaca fascicularis

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Show all anti-Carboxylesterase 1 (CES1) Anticorps with Pubmed References

Human Carboxylesterase 1 (CES1) interaction partners

Pig (Porcine) Carboxylesterase 1 (CES1) interaction partners

Antigen Summary

Alternative names and synonyms associated with Carboxylesterase 1 (CES1)

Protein level used designations for CES1