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Human Monoclonal GABPA Primary Antibody pour ICC, ELISA - ABIN969163
Batchelor, Piper, de la Brousse, McKnight, Wolberger: The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. dans Science (New York, N.Y.) 1998
Show all 3 Pubmed References
Human Polyclonal GABPA Primary Antibody pour IF (p), IHC (p) - ABIN1714176
Chang, Wu, Xu, Liao, Wu, Cheng: Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation. dans Molecules (Basel, Switzerland) 2015
Human Polyclonal GABPA Primary Antibody pour ICC, IF - ABIN4313121
Sharma, Massie, Butter, Mann, Bon, Ramos-Montoya, Menon, Stark, Lamb, Scott, Warren, Neal, Mills: The ETS family member GABP? modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer. dans Nucleic acids research 2014
Collectively, our data indicate that GABPA inhibits hepatocellular carcinoma cell migration and could serve as a novel biomarker for prognosis
CRISPR-mediated reversal of mutant TERT (Montrer TERT Anticorps) promoters, or deletion of its long-range interacting chromatin, abrogates GABPA binding and long-range interactions, leading to depletion of active histone marks, loss of POL2 recruitment, and suppression of TERT (Montrer TERT Anticorps) transcription
potential mechanism of TERT (Montrer TERT Anticorps) reactivation mediated by a novel long-range chromatin interaction between the TERT (Montrer TERT Anticorps) promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT (Montrer TERT Anticorps) promoters but not in wild-type promoters.
a key role for GABPA/B1 as the critical ETS (Montrer ETS1 Anticorps) transcription factors deregulating SDHD (Montrer SDHD Anticorps) expression in the context of highly recurrent promoter mutations in melanoma.
Analyses of data sets link GABPa to cognitive disorders, diabetes, KRAB zinc finger (KRAB-ZNF (Montrer ZNF629 Anticorps)), and human-specific genes.
ELF1 (Montrer EFNA2 Anticorps) binding occurs at both TERT (Montrer TERT Anticorps) promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS (Montrer ETS1 Anticorps) motifs in the TERT (Montrer TERT Anticorps) promoter region.
The results suggest that NRF-2alpha is a regulator of SIRT3 (Montrer SIRT3 Anticorps) expression and may shed light on how SIRT3 (Montrer SIRT3 Anticorps) is upregulated during nutrient stress.
GABPalpha Binding to Overlapping ETS (Montrer ETS1 Anticorps) and CRE DNA Motifs Is Enhanced by CREB1 (Montrer CREB1 Anticorps)
Expression of the ETS transcription factor (Montrer FEV Anticorps) GABPalpha is positively correlated to the BCR (Montrer BCR Anticorps)-ABL1/ABL1 (Montrer ABL1 Anticorps) ratio in CML (Montrer BCR Anticorps) patients and affects imatinib sensitivity in vitro.
study supports the crucial role of GABP in myeloid cell differentiation and identified ITGAM/CD11b (Montrer ITGAM Anticorps) as a novel GABP target gene
conditionally deleted Gabpa, the DNA-binding component of this transcription factor complex, from embryonic fibroblasts to examine the role of Gabp in mitochondrial biogenesis, function, and gene expression
Loss of Gabpalpha prevented development of CML, although mice continued to generate BCR-ABL (Montrer ABL1 Anticorps)-expressing Gabpalpha-null cells for months that were serially transplantable and contributed to all lineages in secondary recipients.
NRF-2 (Montrer NFE2L2 Anticorps) and NRF-1 (Montrer NRF1 Anticorps) operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.
Through genome-wide mapping of GABPalpha binding and transcriptomic analysis of GABPalpha-deficient HSCs, we identified Zfx (Montrer ZFX Anticorps) and Etv6 (Montrer ETV6 Anticorps) transcription factors and prosurvival Bcl-2 (Montrer BCL2 Anticorps) family members including Bcl-2 (Montrer BCL2 Anticorps), Bcl-X(L (Montrer BCL2L1 Anticorps)), and Mcl-1 (Montrer MCL1 Anticorps) as direct GABP target genes.
Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1.
chemical shift and secondary structure of the PNT (Montrer ETS2 Anticorps)/SAM (Montrer TTN Anticorps) domains
Erralpha and GA-binding protein a partner with PGC-1alpha in muscle to form a double-positive-feedback loop that drives the expression of many oxidative phosphorylation genes
Gabpa function is essential and is not compensated for by other ETS (Montrer ETS1 Anticorps) transcription factors and is consistent with a specific requirement for Gabp expression for the maintenance of target genes involved in embryo essential mitochondrial cellular functions
GABP is essential for the regulation of IL-7Ralpha (Montrer IL7R Anticorps) expression in T cells.
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
GA binding protein transcription factor, alpha subunit 60kDa
, transcription factor GABP alpha subunit
, GA binding protein transcription factor, alpha subunit (60kD)
, GA-binding protein alpha chain-like
, GA repeat binding protein, alpha
, GA-binding protein alpha chain
, nuclear respiratory factor 2 alpha
, GA binding protein transcription factor alpha subunit 60kDa
, GABP subunit alpha
, human nuclear respiratory factor-2 subunit alpha
, nuclear respiratory factor 2 alpha subunit
, nuclear respiratory factor 2 subunit alpha
, transcription factor E4TF1-60
, GA repeat binding protein alpha
, GA-binding protein alpha-subunit
, E4tf1-60 transcription factor