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Data indicate two moderately frequent variants in G protein-coupled receptor kinase 5 (GRK5) and seven very rare polymorphisms in patients with laterality defects (heterotaxy) that were associated with a congenital heart defect (Montrer Vcan Anticorps) (CHD (Montrer CHDH Anticorps)).
demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 and GRK6 (Montrer GRK6 Anticorps), both of which regulate Src (Montrer SRC Anticorps) and IGF-IR signaling and have been implicated in cancer.
Data suggest that perturbation of interface formed between large lobe of kinase domain of GRK5 and the RHD (regulator of G protein signaling homology domain) leads to higher phosphorylation activity/activation of kinase activity.
The role of GRK5 single nucleotide polymorphisms in postoperative atrial fibrillation susceptibility following coronary artery bypass grafting among Chinese population
Candidate gene eQTL (Montrer EQTN Anticorps) showed a trans-acting association between variants of G protein-coupled receptor kinase 5 gene (Montrer GPD1 Anticorps), previously linked to altered BB response, and high expression of VOPP1 (Montrer VOPP1 Anticorps).
Further, we will also present potential therapeutic strategies (i.e. small molecule inhibition, gene therapy) that may have potential in combating the deleterious effects of GRK5 in heart failure.
Suggest a common regulatory pattern for the beta(1)-AR/GRK5 which is independent of cellular type or pathology.
We demonstrated that the SNPs and the related haplotypes of GRK5 could play a central role in predisposing Parkinson disease patients to cognitive impairment.
Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR (Montrer NMUR1 Anticorps) trafficking using a recombinant AM1 receptor and further determined the region of the CLR C-tail responsible for this GRK (Montrer GRK4 Anticorps) function.
ADORA2A (Montrer ADORA2A Anticorps) and GRK5 gene variants may influence the etiology of malaria infection.
Along with other supporting evidence, the authors propose that GRK5 deficiency selectively renders basal forebrain cholinergic neurons more vulnerable to degeneration.
Overall, these data suggest that GRK5 negatively regulates CXCL1/KC (Montrer CXCL1 Anticorps) levels during bacterial pneumonia but that the role of GRK5 in the clinical outcome in this model is dependent on the bacterial dose.
Generated mice with genetic knockout (KO) of the G protein-coupled receptor kinase (GRK) 5 gene (Montrer GPD1 Anticorps) by microinjection of TALEN mRNA. TALEN vectors were designed to target exons 1, 3, and 5 of the mouse GRK5 gene.
These results of this study suggest that GRK5 deficiency indeed makes the mice more susceptible to wide range of behavioral impairments, including cognitive impairments.
MOR (Montrer OPRM1 Anticorps) phosphorylation is regulated by agonist-selective recruitment of distinct GRK (Montrer GRK4 Anticorps) isoforms that influence different opioid-related behaviors. Modulation of GRK5 function could serve as a new approach for preventing addiction to opioids.
GRK5, acting in a kinase independent manner, is a facilitator of NFAT (Montrer NFATC1 Anticorps) activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.
influence of GRK5 on NF-kappaB (Montrer NFKB1 Anticorps) expression and activity
these data identified GRK5 as a positive regulator of insulin (Montrer INS Anticorps) sensitivity.
metoprolol is a biased ligand that selectively activates a G protein-independent and GRK5/beta-arrestin2 (Montrer ARRB2 Anticorps)-dependent pathway, and induces cardiac fibrosis.
These results define myocyte GRK5 as a critical regulator of pathological cardiac growth after ventricular pressure overload, supporting its role as an endogenous (patho)-physiological HDAC (Montrer HDAC3 Anticorps) kinase.
potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
GRK2 (Montrer ADRBK1 Anticorps) and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 (Montrer LRP5 Anticorps) during Wnt (Montrer WNT2 Anticorps) signaling.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
, g protein-coupled receptor kinase GRK5
, G protein-coupled receptor kinase 5
, G protein-coupled receptor kinase 6