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Full name:: anti-G Protein-Coupled Receptor Kinase 5 Anticorps (GRK5)

Chez www.anticorps-enligne.fr sont 160 G Protein-Coupled Receptor Kinase 5 (GRK5) Anticorps de 26 de différents fournisseurs disponibles. De plus, nous expédions G Protein-Coupled Receptor Kinase 5 Protéines (14) et G Protein-Coupled Receptor Kinase 5 Kits (9) et beaucoup plus de produits pour cette protéine. Un total de 190 G Protein-Coupled Receptor Kinase 5 produits sont actuellement listés.

Synonymes:: DKFZp468J1119, Gprk5, grk5, si:dkey-171l20.1

afficher tous les anticorps	Gène	GeneID	UniProt
	GRK5	2869	P34947
	GRK5	14773	Q8VEB1
	GRK5	59075	Q62833
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Human G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

Data indicate two moderately frequent variants in G protein-coupled receptor kinase 5 (GRK5) and seven very rare polymorphisms in patients with laterality defects (heterotaxy) that were associated with a congenital heart defect (Montrer Vcan Anticorps) (CHD (Montrer CHDH Anticorps)).
demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 and GRK6 (Montrer GRK6 Anticorps), both of which regulate Src (Montrer SRC Anticorps) and IGF-IR signaling and have been implicated in cancer.
Data suggest that perturbation of interface formed between large lobe of kinase domain of GRK5 and the RHD (regulator of G protein signaling homology domain) leads to higher phosphorylation activity/activation of kinase activity.
The role of GRK5 single nucleotide polymorphisms in postoperative atrial fibrillation susceptibility following coronary artery bypass grafting among Chinese population
Candidate gene eQTL (Montrer EQTN Anticorps) showed a trans-acting association between variants of G protein-coupled receptor kinase 5 gene (Montrer GPD1 Anticorps), previously linked to altered BB response, and high expression of VOPP1 (Montrer VOPP1 Anticorps).
Further, we will also present potential therapeutic strategies (i.e. small molecule inhibition, gene therapy) that may have potential in combating the deleterious effects of GRK5 in heart failure.
Suggest a common regulatory pattern for the beta(1)-AR/GRK5 which is independent of cellular type or pathology.
We demonstrated that the SNPs and the related haplotypes of GRK5 could play a central role in predisposing Parkinson disease patients to cognitive impairment.
Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR (Montrer NMUR1 Anticorps) trafficking using a recombinant AM1 receptor and further determined the region of the CLR C-tail responsible for this GRK (Montrer GRK4 Anticorps) function.
ADORA2A (Montrer ADORA2A Anticorps) and GRK5 gene variants may influence the etiology of malaria infection.

Mouse (Murine) G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

Along with other supporting evidence, the authors propose that GRK5 deficiency selectively renders basal forebrain cholinergic neurons more vulnerable to degeneration.
Overall, these data suggest that GRK5 negatively regulates CXCL1/KC (Montrer CXCL1 Anticorps) levels during bacterial pneumonia but that the role of GRK5 in the clinical outcome in this model is dependent on the bacterial dose.
Generated mice with genetic knockout (KO) of the G protein-coupled receptor kinase (GRK) 5 gene (Montrer GPD1 Anticorps) by microinjection of TALEN mRNA. TALEN vectors were designed to target exons 1, 3, and 5 of the mouse GRK5 gene.
These results of this study suggest that GRK5 deficiency indeed makes the mice more susceptible to wide range of behavioral impairments, including cognitive impairments.
MOR (Montrer OPRM1 Anticorps) phosphorylation is regulated by agonist-selective recruitment of distinct GRK (Montrer GRK4 Anticorps) isoforms that influence different opioid-related behaviors. Modulation of GRK5 function could serve as a new approach for preventing addiction to opioids.
GRK5, acting in a kinase independent manner, is a facilitator of NFAT (Montrer NFATC1 Anticorps) activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.
influence of GRK5 on NF-kappaB (Montrer NFKB1 Anticorps) expression and activity
these data identified GRK5 as a positive regulator of insulin (Montrer INS Anticorps) sensitivity.
metoprolol is a biased ligand that selectively activates a G protein-independent and GRK5/beta-arrestin2 (Montrer ARRB2 Anticorps)-dependent pathway, and induces cardiac fibrosis.
These results define myocyte GRK5 as a critical regulator of pathological cardiac growth after ventricular pressure overload, supporting its role as an endogenous (patho)-physiological HDAC (Montrer HDAC3 Anticorps) kinase.

Cow (Bovine) G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

GRK5, acting in a kinase independent manner, is a facilitator of NFAT (Montrer NFATC1 Anticorps) activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.
potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.

Zebrafish G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

GRK2 (Montrer ADRBK1 Anticorps) and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.
Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 (Montrer LRP5 Anticorps) during Wnt (Montrer WNT2 Anticorps) signaling.

G Protein-Coupled Receptor Kinase 5 (GRK5) profil antigène

Antigen Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).

Alternative names and synonyms associated with G Protein-Coupled Receptor Kinase 5 (GRK5)

G protein-coupled receptor kinase 5 (GRK5) anticorps
G protein-coupled receptor kinase 5 (Grk5) anticorps
G protein-coupled receptor kinase 5 (grk5) anticorps
G protein-coupled receptor kinase 5 L homeolog (grk5.L) anticorps

DKFZp468J1119 anticorps
Gprk5 anticorps
grk5 anticorps
si:dkey-171l20.1 anticorps

Protein level used designations for GRK5

FP2025 , g protein-coupled receptor kinase GRK5 , G protein-coupled receptor kinase 5 , G protein-coupled receptor kinase 6

GENE ID	SPECIES
2869	Homo sapiens
14773	Mus musculus
59075	Rattus norvegicus
281801	Bos taurus
423929	Gallus gallus
486915	Canis lupus familiaris
550070	Xenopus (Silurana) tropicalis
560806	Danio rerio
100171722	Pongo abelii
100593251	Nomascus leucogenys
100065919	Equus caballus
100152937	Sus scrofa
100719009	Cavia porcellus
733256	Xenopus laevis

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