Aperçu des produits pour anti-G Protein-Coupled Receptor Kinase 5 (GRK5) Anticorps

Human G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

1. Loss of GRK5 expression is associated with cardiac hypertrophy.

2. There was no association of SNPs in ADRB1, GRK5 and BAG3 genes with Takotsubo cardiomyopathy.

3. T2DM patients with genotypes CC and CT at GRK5 rs10886471 had a significant reduction in terms of fasting plasma glucose compared with those with genotype TT (p < .01). In addition, the carriers of genotypes CC and CT at GRK5 rs10886471 had higher differential values of postprandial serum insulin compared with genotype TT carriers (p < .05).

4. Data indicate two moderately frequent variants in G protein-coupled receptor kinase 5 (GRK5) and seven very rare polymorphisms in patients with laterality defects (heterotaxy) that were associated with a congenital heart defect (CHD).

5. demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 and GRK6, both of which regulate Src and IGF-IR signaling and have been implicated in cancer.

6. Data suggest that perturbation of interface formed between large lobe of kinase domain of GRK5 and the RHD (regulator of G protein signaling homology domain) leads to higher phosphorylation activity/activation of kinase activity.

7. The role of GRK5 single nucleotide polymorphisms in postoperative atrial fibrillation susceptibility following coronary artery bypass grafting among Chinese population

8. Candidate gene eQTL showed a trans-acting association between variants of G protein-coupled receptor kinase 5 gene, previously linked to altered BB response, and high expression of VOPP1.

9. Further, we will also present potential therapeutic strategies (i.e. small molecule inhibition, gene therapy) that may have potential in combating the deleterious effects of GRK5 in heart failure.

10. Suggest a common regulatory pattern for the beta(1)-AR/GRK5 which is independent of cellular type or pathology.

11. We demonstrated that the SNPs and the related haplotypes of GRK5 could play a central role in predisposing Parkinson disease patients to cognitive impairment.

12. Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR trafficking using a recombinant AM1 receptor and further determined the region of the CLR C-tail responsible for this GRK function.

13. ADORA2A and GRK5 gene variants may influence the etiology of malaria infection.

14. A significant difference in the frequency of GRK5 polymorphism was found between Takotsubo cardiomyopathy patients and controls, supporting a genetic predisposition to this cardiac syndrome.

15. Specific patterns of altered heart GRK5 gene expression were found in models of cardiac hypertrophy.

16. This study sought to identify the distributed characteristics of these variant genotypes in Chinese population, and influence of GRK5 and ADRB1 polymorphisms on systolic heart failure morbidity.

17. GRK5 is found in a partially closed state with its kinase domain C-tail forming novel interactions with nucleotide and the N-lobe.

18. G protein-coupled receptor kinase 5 gene polymorphisms may have a role in postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving beta-blockers

19. These data suggest that increased GRK5 expression may contribute to the pathophysiology of schizophrenia.

20. Results demonstrate crosstalk among WIP1, CXCR4 and GRK5, which may be important for the aggressive phenotype of a subclass of medulloblastomas in children.

Mouse (Murine) G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

1. Along with other supporting evidence, the authors propose that GRK5 deficiency selectively renders basal forebrain cholinergic neurons more vulnerable to degeneration.

2. Overall, these data suggest that GRK5 negatively regulates CXCL1/KC levels during bacterial pneumonia but that the role of GRK5 in the clinical outcome in this model is dependent on the bacterial dose.

3. Generated mice with genetic knockout (KO) of the G protein-coupled receptor kinase (GRK) 5 gene by microinjection of TALEN mRNA. TALEN vectors were designed to target exons 1, 3, and 5 of the mouse GRK5 gene.

4. These results of this study suggest that GRK5 deficiency indeed makes the mice more susceptible to wide range of behavioral impairments, including cognitive impairments.

5. MOR phosphorylation is regulated by agonist-selective recruitment of distinct GRK isoforms that influence different opioid-related behaviors. Modulation of GRK5 function could serve as a new approach for preventing addiction to opioids.

6. GRK5, acting in a kinase independent manner, is a facilitator of NFAT activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.

7. influence of GRK5 on NF-kappaB expression and activity

8. regulator of inflammation and thymic apoptosis in polymicrobial sepsis

9. these data identified GRK5 as a positive regulator of insulin sensitivity.

10. metoprolol is a biased ligand that selectively activates a G protein-independent and GRK5/beta-arrestin2-dependent pathway, and induces cardiac fibrosis.

11. These results define myocyte GRK5 as a critical regulator of pathological cardiac growth after ventricular pressure overload, supporting its role as an endogenous (patho)-physiological HDAC kinase.

12. these results suggest that GRK5 is an important regulator of adipogenesis and is crucial for the development of diet-induced obesity.

13. GRK5 regulates IL-12p40 and G-CSF via a mechanism that is common to both MyD88 and TRIF.

14. G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.

15. GRK5 is a positive regulator of TLR4-induced IkappaBalpha-NFkappaB pathway as well as a key modulator of LPS-induced inflammatory response.

16. GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity

17. GRK5 as a novel kinase of p53, as well as a negative regulator of p53-mediated signal transduction.

18. Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling.

19. Results demonstrate that both GRK2 and GRK5 are important and novel mediators of a non-traditional IkappaBalpha/NF-kappaB signalling pathway.

20. GRK5 regulates pulmonary responses in a tissue- and receptor-specific manner but does not regulate peripheral cardiac muscarinic receptors.

Cow (Bovine) G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

1. GRK5, acting in a kinase independent manner, is a facilitator of NFAT activity and part of a DNA-binding complex responsible for pathological hypertrophic gene transcription.

2. potential GRK5 interacting proteins and the association of GRK5 with DDB1 in cell and the regulation of GRK5 level by DDB1-CUL4 ubiquitin ligase complex-dependent proteolysis pathway

3. GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.

Zebrafish G Protein-Coupled Receptor Kinase 5 (GRK5) interaction partners

1. GRK2 and GRK5 control cardiac function as well as morphogenesis during development although with different morphological outcomes.

2. Grk5l influences development of the heart during its early formation.

3. Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling.