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These results demonstrate that insulin PDK1-dependently preferentially activates paraventricular nucleus magnocellular oxytocin neurons to release oxytocin into circulation, possibly serving as a mechanism for the interaction between metabolism and perinatal functions.
Oxytocin regulates colonic motility via oxytocin receptor in myenteric plexus.
Oxytocin through the down-regulation of ER and NF-kappaB inhibition can induce miR-195 up-regulation which it can promote the apoptosis of breast cancer cells and the inhibition of cell proliferation.
SIRT1 promotes FGF21 signalling in oxytocin neurons and stimulates Oxt transcription through NRF2.
Data indicate that oxytocin (OT) is transmitted via a receptor-mediated process.
OT plays critical roles in thermoregulation and also highlight the entanglement of social and thermoregulatory processes in small mammals such as mice.
a novel link between BDNF signaling, oxytocin, and maternal behavior, is reported.
Caffeine excites oxytocin expressing neurons, and blockade of the action of oxytocin significantly attenuates the effect of caffeine on energy balance.
The abnormal social behaviors of Dio3-/- mice were associated with sexually dimorphic alterations in the physiology of oxytocin (OXT) and arginine vasopressin (AVP), 2 neuropeptides with important roles in determining social interactions.
Data indicate that oxytocin participates in the spine remodeling, synaptic refinement, and social stimuli-dependent plasticity in the posterodorsal medial amygdala of male mice.
Activation of the oxytocin receptor in brain regions facilitates social defeat posture.
the absence of OT leads to significant changes in the expression of the studied genes (OTR, ERalpha, ERbeta, V1aR), and these changes may contribute to the decreased sexual behavior observed in OT gene knockout females.
These results reveal that Oxt protects pancreatic beta cells against death caused by metabolic stress, and Oxt signaling may be a potential therapeutic target.
CA3 pyramidal cells in the adult mouse hippocampus express OXT receptors and receive inputs from hypothalamic OXT neurons.
These results identify G9a-induced histone methylation at the OXT and AVP promoters in the Basolateral Amygdala as a mechanism for mediating stress-induced lasting behavioral depression and its reversal by exercise.
Data indicate that oxytocin is an important synaptic modulator in the posterodorsal medial amygdala, a finding that is likely involved with the display of the female sexual behavior.
OXT was up-regulated in both hypothalamic magnocellular neurosecretory cells and parvocellular cells by chronic inflammation, and also that OXT in the PVN-spinal pathway may be involved in sensory modulation
role for a neuronal population in the control of maternal care and oxytocin secretion; and evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour
Oxtr signaling is crucial for entrainment of odor to social cues but is dispensable for entrainment to nonsocial cues. Oxt conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning.
Oxytocin is is required for proper muscle tissue regeneration and homeostasis, and that plasma levels of oxytocin decline with age. Genetic lack of oxytocin does not cause a developmental defect in muscle but instead leads to premature sarcopenia.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
Oxytocin (OT) mRNA and protein levels were lower in the corpus luteum of pregnancy than in the corpus luteum of the estrous cycle.
These data suggest that cortisol affects oxytocin synthesis and secretion in bovine ovarian cells, by acting on the expression of key genes, that may impair ovary
Binding of oestrogen receptor-related receptor alpha to the oxytocin promoter binding site is demonstrated, suggesting the involvement of this receptor in oestrogen-dependent up-regulation.
data demonstrate an effect of dimerization in the unliganded state on the hormone-binding site involving residues that interact with hormone residue 2, & identify Ser25 & Ile26 as likely intermediaries between the sites of dimerization & hormone binding
loop status modulates dimerization via long-range effects on neurophysin conformation involving neighboring Phe22 as a key intermediary
Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 and PGF(2alpha) within the corpus luteum.
REVIEW: findings on endogenous OXT levels and their relationship to eating disorders pathology, the impact of exogenous OXT on mechanisms that drive ED presentation and chronicity, and the potential role of genetic predispositions in the OXT-ED link
Group comparisons revealed lower plasma OT levels in the schizophrenia group compared to healthy controls. Correlations revealed that lower levels of OT were associated with poorer levels of metacognitive functioning in the schizophrenia group but not poorer social cognition or neurocognition.
REVIEW: recent advances in animal research on the analgesic effects of oxytocin and discuss possible target sites of oxytocin within descending and ascending pain pathways in the brain
women who did and did not become pregnant after embryo transfer did not have significantly different oxytocin levels
The OT concentration in the pooled saliva of preterm infant twins decreased during kangaroo care. This response of the OT system might be explained by stress during baseline.
oxytocin and its receptor play a role in synapse structure, function, and neuron connectivity and this implicates that alterations in oxytocin signaling could be involved in synaptopathies.
Evidence suggests the physiological functions of OT are multiple. OT participates to coordination and control of gonadal development and reproduction. OT appears also as an important regulator of social behaviors such as affiliative, parental, and romantic behaviors. [REVIEW]
The results suggest that there is an age-dependent association between visual attention for social cues and oxytocin (OT) levels in infants and children, and that the development of visual attention to the eyes as social cues is associated with both OXTR polymorphisms and OT levels.
Although some SNPs were associated at an alpha level of .05 with breastfeeding, they did not survive multiple testing correction. Authors conclude that SNPs within or nearby OXT and OXTR are unlikely to have large effects on breastfeeding behavior.
Oxytocin gene polymorphisms and parenting G x E interaction on social anxiety levels in adolescents.
serum oxytocin levels were higher among women than men and were negatively associated with strength of belief in life after death
A significant moderating effect of OXT genotype (rs2740210) on the relationship between social support and psychiatric distress was detected
findings suggested more significant plasma oxytocin dysregulation in the patients in the bipolar II disorder group than in the major depressive disorder patients and controls, both before and after treatment
Oxytocin level did not vary significantly between healthy controls, healthy controls with a history of sexual abuse, and psychogenic non-epileptic seizure patients with a history of sexual abuse.
These results suggest that OXT and OXTR are controlled mainly by E2 in the placenta via ESR1 and thus may play physiological functions in the human placenta during the late stage of pregnancy.
Study found a higher expression of paraventricular nucleus OXT in the mood disorder patients than in the control subjects, and observed a clear co-localization of androgen receptor in OXT-expressing neurons, both in the cytoplasm and in the nucleus. In addition, a significant decrease in OXT-mRNA levels was observed after pre-incubation of the SK-N-SH cells with testosterone.
Serum and prostatic oxytocin levels are increased in the PCa subjects. Serum oxytocin level may be a biomarker for PCa in the future. Oxytocin increases PCa growth and APPL1 expression.
Obese children had significantly higher irisin and lower oxytocin levels than the healthy controls.
study found that rs6133010 in the OXT gene is associated with alcohol dependence in the northern Chinese Han population
OXT levels were lowest in anorexia nervosa, higher in healthy controls, and highest in obesity. There were positive associations between OXT and body mass index, total, visceral, and subcutaneous fat, and bone mineral density.
The presence of oxytocin in the mare uterus was determined by radioimmunoassay of tissue extracts and uterine lavage fluid, and by immunohistochemistry.
The effects of oestrogen and progesterone in the regulation of oxytocin gene expression in equine endometrium were examined.
The roles of oxytocin and dinoprost in persistent mating-induced endometritis in mares are reported.
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
, oxytocin-neurophysin 1
, oxytocin, prepro- (neurophysin I)
, oxytocin, prepropeptide
, oxytocin/neurophysin (Oxt) gene, complete gene, complete cds
, neurophysin I
, oxytocin-neurophysin I, preproprotein
, oxytocin-neurophysin I