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Data suggest that Gpr176 (G-protein coupled receptor 176 (Montrer GPR176 Protéines)) is an SCN (Montrer SRI Protéines)-(suprachiasmatic nucleus-)enriched orphan GPCR (Montrer NMUR1 Protéines) (G-protein-coupled receptor (Montrer ADRA1A Protéines)) that sets the pace of circadian behavior; a unique cAMP-repressing G-protein subclass Gz is required for the activity of Gpr176 (Montrer GPR176 Protéines). [REVIEW]
These results suggest that the expression of RGS20 may promote metastasis of tumor cells.
Findings suggest that high regulator of G protein signaling 20 (RGS20) expression is associated with unfavorable survival in triple-negative breast cancer (TNBC).
provide new evidence that RGSZ1 interacts not only with Galpha (Montrer SUCLG1 Protéines)(z,) but also with Galpha (Montrer SUCLG1 Protéines)(i), as supported by in vitro binding assays and functional studies
The major function of PKCI-1 (Montrer HINT1 Protéines) is to modulate mu opioid receptor (Montrer OPRM1 Protéines) signaling pathway along with RGSZ1, rather than directly mediating the Galphaz RGSZ1 interaction.
RGSz1 function suppression optimizes the actions of opioid analgesics by mechanisms that involve the Wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) pathway
Analysis of in vitro microtubule polymerization/depolymerization showed that binding of RGSZ1 to SCG10 (Montrer STMN2 Protéines) effectively blocked the ability of SCG10 (Montrer STMN2 Protéines) to induce microtubule disassembly
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, gz-selective GTPase-activating protein
, regulator of G-protein signaling 20 variant 2
, regulator of G-protein signaling Z1
, regulator of G-protein signalling 20
, regulator of Gz-selective protein signaling 1
, Gz-selective GTPase-activating protein
, Gz-specific GAP
, RGS protein Gz-GAP
, retina-specific regulator of G-protein signaling 1