Profil protéine

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed\; however, the transcript variants have not been fully described.

Alternative names and synonyms associated with ABCC8

• ATP binding cassette subfamily C member 8 (ABCC8) anticorps
• ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (Abcc8) anticorps
• ATP binding cassette subfamily C member 8 (Abcc8) anticorps

• ABC36 anticorps
• D930031B21Rik anticorps
• HHF1 anticorps
• HI anticorps
• HRINS anticorps
• Afficher tous les alias de synonymes
• MRP8 anticorps
• PHHI anticorps
• Sur anticorps
• Sur1 anticorps
• SUR1delta2 anticorps
• TNDM2 anticorps

Protein level used designations for ABCC8

ATP-binding cassette, sub-family C (CFTR/MRP), member 8 , ATP-binding cassette, sub-family C, member 8 , ATP-binding cassette sub-family C member 8 , ATP-binding cassette transporter sub-family C member 8 , sulfonylurea receptor (hyperinsulinemia) , sulfonylurea receptor 1 , sulfonylurea receptor , sulphonylurea receptor 1