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Authors examined, for the first time in a Turkish population, the association between protamine gene alleles (PRM1 c.-190C>A, PRM1 c.197G>T, and PRM2 c.248C>T), and YBX2 (c.187T>C and c.1095 + 16A>G) and male infertility.
Data suggest that DNA binding protein A (dbpA) may be used as a therapeutic target in colorectal cancer (CRC).
dbpA knockdown in SW620 cells altered the expression of carcinogenesis-associated genes in Colorectal cancer.
In the prenatal brain, the cold shock domain protein A were found to be abundantly expressed in radial glial cells, neuroblasts and neurons.
Stratification according to Fuhrman grade disclosed higher YBX3 expression levels.
We demonstrate that ZONAB promotes cell survival in response to proinflammatory, hyperosmotic, and cytotoxic stress and that stress-induced ZONAB activation involves the Rho regulator GEF-H1.
DbpA promoter was methylated in 37.7% of HCC samples.
In human skeletal muscle cells, CSDA was upregulated during hypoxia when cells were damaged and apoptosis was induced.
ZONAB is an important component of the mechanisms that sense epithelial density and participates in the complex transcriptional networks that regulate the switch between proliferation and differentiation
The expression of human DBPA was upregulated in gastric cancer tissues and cell lines. siRNA treatment successfully silenced DBPA expression.
human dbpA has a role in accelerating hepatocarcinogenesis
identification of complexes, binding to the vascular endothelial growth factor mRNA 5'- and 3'-UTR, that contain cold shock domain and polypyrimidine tract binding RNA binding proteins
ZONAB regulates the transcription of genes that are important for G1/S-phase progression and links tight junctions to the transcriptional control of key cell cycle regulators and epithelial cell differentiation.
The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1.
homozygous double mutants could not be generated as haploinsufficiency of both Ybx2 and Ybx3 caused sterility characterized by extensive defects in spermatid differentiation.
In a hindlimb ischemia model, transfer of short-hairpin RNA targeting CSDA ameliorated ischemia without direct transfer of angiogenic factors.
ZO-1 and ZONAB are critical for differentiation and homeostasis of the RPE monolayer and may be involved in RPE disorders such as proliferative vitroretinopathy and atrophic age-related macular degeneration
results indicated CD133(+) subpopulation of SW480 SCPs bear heterogeneous invasive and metastatic ability, and CRC-CSCs might be a heterogeous subpopulation
MSY4 is an important component of the mechanisms that sense epithelial density and participates in the complex transcriptional networks that regulate the switch between proliferation and differentiation
results suggest that MSY4 plays an active role in translational repression of several mRNAs in differentiating spermatids
Embryos doubly deficient for YB-1 and MSY4 are severely runted and die much earlier (E8.5 to E11.5) than YB-1-deficient embryos, suggesting that MSY4 indeed shares critical cellular functions with YB-1 in the embryonic tissues where they are coexpressed.
Loss of Cold shock domain protein A leads to angiogenesis and lymphangiogenesis
acts as a transcriptional repressor of the nicotinic acetylcholine receptor delta-subunit gene
DNA-binding protein A
, Y-box-binding protein 3
, ZO-1-associated nucleic acid-binding protein
, cold shock domain protein A
, cold shock domain-containing protein A
, cold-shock domain containing A1
, cold-shock domain protein A
, single-strand DNA-binding protein NF-GMB
, Y-box protein
, Y-box protein 3
, Y-box-binding protein A
, muscle Y-box protein YB2
, Y-box protein ZONAB-A