Aperçu des produits pour anti-MUC1 (MUC1) Anticorps

Human Mucin 1, Cell Surface Associated (MUC1) interaction partners

1. Mutated MUC1 (insC) affects vesicular transport in renal epithelial cells. It changes gene expression of vesicular transport-associated proteins, for example VTA1.

2. MUC1-C thereby contributes to the integration of PRC2 and PRC1-mediated repression of tumor suppressor genes, such as CDH1, CDKN2A, PTEN and BRCA1. Like PRC2 and PRC1, MUC1-C is associated with the epithelial-mesenchymal transition (EMT) program, cancer stem cell (CSC) state, and acquisition of anticancer drug resistance. [review]

3. MUC-1, CK7, and c-p27 immunostaining can be used as the predictive markers for esophageal cancer progression from Barrett's esophagus.

4. The CA 15-3 assay using 115D8-DF3 antibody pair is more suitable for monitoring therapy in pregnancy-associated breast cancer

5. MUC1-CT (cytoplasmic tail) expression was downregulated in lung tissue, bronchial epithelial cells and lung neutrophils from smokers and in COPD and it was correlated with their FEV1%

6. MiR-326 functioned as a tumor suppressor in PCa by negatively regulating MUC1.

7. To achieve this, using semi-quantitative mass spectrometry, we found MUC1 to be significantly and durably upregulated in response to erlotinib, an EGFR-targeting treatment. MUC1 upregulation was regulated transcriptionally, involving PI3K-signaling and STAT3

8. Studies demonstrate that MUC1-C-terminal beta subunit drives EZH2 expression in TNBC, NSCLC and other types of carcinoma cells. MUC1-C activates the EZH2 promoter through induction of the pRB-->E2F pathway. MUC1-C binds directly to the EZH2 CXC region adjacent to the catalytic SET domain and associates with EZH2 on the CDH1 and BRCA1 promoters.

9. Findings indicate that linc01296/miR-26a/GALNT3 axis involves in the progression of CRC cells, illuminating the possible mechanism mediated by O-glycosylated MUC1 via PI3K/AKT pathway.

10. The most strong relationship was registered between levels of expression of genes MUC I and IL32 (r-0.72; p=0.0001). In comparison with MUC I negative breast carcinoma, MUC I positive breast carcinoma characterized by higher level of mRNA of pro-inflammatory cytokines IL32 and capital IE, Cyrilliccapital TE, Cyrilliccapital A, Cyrillic

11. Study demonstrated that MCU1 is frequently overexpressed in breast cancer and abnormally high expression of MUC1 indicates poor prognosis. Subsequent data mining across multiple large databases demonstrated a positive association between MUC1 mRNA expression CREB3L4 in breast cancer tissues. Results indicated that MUC1 transcript expression may regulate tumor invasion and metastasis associated with CREB3L4 transcription.

12. A combination of tissue overexpression of MUC1, reduced MUC2 expression, and high ratio of MUC1/MUC2 is a factor of poor prognosis in colorectal cancer (CRC) patients. MUC2 tissue expression allows to differentiate mucinous and non-mucinous CRC subtypes.

13. Threonyl-tRNA synthetase regulates MUC1 biosynthesis in pancreatic cancer cells.MUC1 role in the pancreatic cancer cell migration.

14. Studied predictive use of mucin 1 (KL-6) serum level as a biomarker in development of bronchopulmonary dysplasia in preterm infants.

15. we wanted to explore whether STAT3 can be related to lymph node micrometastasis of non-small cell lung cancer (NSCLC). To address this question, we evaluated the expression of MUC1 mRNA in the lymph node samples of NSCLC to determine micrometastasis. Then, we evaluated what role STAT3 overexpression plays in lymph node micrometastasis of NSCLC.

16. these data showed that sustained abnormal MUC1 induction accompanies failing epithelial repair, chronic inflammation and kidney fibrosis. In conclusion, MUC1 exerts opposite effects during kidney response to IR: first protective and then harmful

17. The expression profile of studied Mucins MUC16 and MUC1 and truncated O-glycans was not associated with the site of origin of ovarian cancer (OVCA) cell lines

18. MUC1 contributes to immune escape in an aggressive form of triple-negative breast cancer.MUC1 drives PD-L1 expression in triple-negative breast cancer cells.

19. Results show MUC1 expression highly expressed at mRNA and protein levels in esophageal squamous cell carcinoma (ESCC). MUC1 expression correlated with tumor invasion, lymph node metastasis, and TNM staging.

20. Correlation was also observed in the % change of CA 15-3 and CA 27.29 results between consecutive specimens for individual patients. Using doubling or halving thresholds (i.e., 100% increase or 50% decrease), concordance in % change was observed between CA 15-3 and CA 27.29 in approximately 90% of cases. Individual patient results trended similarly across both markers over time

Pig (Porcine) Mucin 1, Cell Surface Associated (MUC1) interaction partners

1. The results indicate that Muc1 gene is significantly associated with litter size in pigs.

2. Adhesion between Lactococcus lactis, the model for lactic acid bacteria (LAB) and mucins, is reported.

3. The epiblast expressed epithelial markers, MUC1 and E-CADHERIN, and the pluripotency markers, DNMT3B and CRIPTO.

Cow (Bovine) Mucin 1, Cell Surface Associated (MUC1) interaction partners

1. Endometrial expressions of MUC1 and cytokine genes differed among normal, fertile versus diseased, and subfertile dairy cows.

2. Bovine Muc1 prevents binding of bacteria to human intestinal cells and may have a role in preventing the binding of common enteropathogenic bacteria to human intestinal epithelial surfaces.

3. concluded that bovine Muc1 protein is probably an inducible innate immune effector and an important component of the first line of defense against bacterial invasion of epithelial surfaces

Mouse (Murine) Mucin 1, Cell Surface Associated (MUC1) interaction partners

1. The results showed that co-administration of an adjuvant plasmid and a DNA vaccine stimulated the production of higher titers of specific antibodies and a T cell response and suppressed the growth of subcutaneous tumors expressing MUC1.

2. these data showed that sustained abnormal MUC1 induction accompanies failing epithelial repair, chronic inflammation and kidney fibrosis. In conclusion, MUC1 exerts opposite effects during kidney response to IR: first protective and then harmful

3. MUC1 plays an important role in protection against severe pneumococcal disease, potentially mediated by facilitating macrophage phagocytosis.

4. this study implicates the MUC1 as a critical and dynamic component of the innate host response that limits the severity of influenza and provides the foundation for exploration of MUC1 in resolving inflammatory disease

5. Tumor growth delays observed by tumor irradiation combined with MVA-MUC1-IL-2 vaccine were significantly more prolonged than those observed by vaccine, radiation, or radiation with MVA empty vector.

6. Muc1 has anti-fibrotic properties in the mouse lung.

7. our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1-dependent VEGFR signaling in PDA cells.

8. Low expression of MUC1 is associated with lung carcinogenesis.

9. Using an extensive collection of novel murine cell lines we have identified distinct roles for Kras and Pten on MUC1 and EMT in vivo and in vitro. The data has implications for future design of combination therapies targeting Kras mutations, Pten deletions and MUC1 vaccines.

10. Gp91phox NADPH oxidase modulates litter size by up-regulating mucin1 expression in the uterus of mice.

11. In summary, we have demonstrated that MUC1 on immune cells is a novel regulator of the NLRP3 inflammasome, and propose this is mediated by an interaction with signalling components at the cytoplasmic domains of TLRs that involves inhibition of IRAK4 activation.

12. MUC1 regulates IL-1beta secretion induced by the NLRP3-activating bacteria Haemophilus influenzae but not bacteria that activate other inflammasomes.

13. Muc1 protection during acute kidney injury proceeds by enhancing both the HIF-1 and beta-catenin protective pathways.

14. MAMs MUC1 and MUC16 contribute to the maintenance of immune homeostasis at the ocular surface by limiting TLR-mediated innate immune responses.

15. the present study provides evidence that Muc1 is a direct target of let-7a and let-7b in mouse uteri during embryo implantation.

16. Anatomical site-specific Cre-loxP recombination throughout the genital tract of MUC1KrasPten mice leads to MUC1 positive genital tract tumors, and the development of these tumors is influenced by the anatomical environment

17. Muc1 clearly plays a significant role in enhancing the hypoxia-inducible transcription factors protective pathway during ischemic insult and recovery in kidney epithelia

18. Epithelial Muc1 is important for gastric mucosa healing by enhancing cell migration and proliferation.

19. the present study provides evidence that MUC1 is a direct target of miRNA-199a during embryo implantation.

20. Helicobacter pylori infection is the most definite insult leading to gastric cancer, and a protective function of mucin 1 protein has been suggested by studies on Muc1 knocked-out mice.