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Study demonstrated that MCU1 is frequently overexpressed in breast cancer and abnormally high expression of MUC1 indicates poor prognosis. Subsequent data mining across multiple large databases demonstrated a positive association between MUC1 mRNA expression CREB3L4 in breast cancer tissues. Results indicated that MUC1 transcript expression may regulate tumor invasion and metastasis associated with CREB3L4 transcription.
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A combination of tissue overexpression of MUC1, reduced MUC2 expression, and high ratio of MUC1/MUC2 is a factor of poor prognosis in colorectal cancer (CRC) patients. MUC2 tissue expression allows to differentiate mucinous and non-mucinous CRC subtypes.
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Threonyl-tRNA synthetase regulates MUC1 biosynthesis in pancreatic cancer cells.MUC1 role in the pancreatic cancer cell migration.
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Studied predictive use of mucin 1 (KL-6) serum level as a biomarker in development of bronchopulmonary dysplasia in preterm infants.
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we wanted to explore whether STAT3 can be related to lymph node micrometastasis of non-small cell lung cancer (NSCLC). To address this question, we evaluated the expression of MUC1 mRNA in the lymph node samples of NSCLC to determine micrometastasis. Then, we evaluated what role STAT3 overexpression plays in lymph node micrometastasis of NSCLC.
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these data showed that sustained abnormal MUC1 induction accompanies failing epithelial repair, chronic inflammation and kidney fibrosis. In conclusion, MUC1 exerts opposite effects during kidney response to IR: first protective and then harmful
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The expression profile of studied Mucins MUC16 and MUC1 and truncated O-glycans was not associated with the site of origin of ovarian cancer (OVCA) cell lines
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MUC1 contributes to immune escape in an aggressive form of triple-negative breast cancer.MUC1 drives PD-L1 expression in triple-negative breast cancer cells.
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Results show MUC1 expression highly expressed at mRNA and protein levels in esophageal squamous cell carcinoma (ESCC). MUC1 expression correlated with tumor invasion, lymph node metastasis, and TNM staging.
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Correlation was also observed in the % change of CA 15-3 and CA 27.29 results between consecutive specimens for individual patients. Using doubling or halving thresholds (i.e., 100% increase or 50% decrease), concordance in % change was observed between CA 15-3 and CA 27.29 in approximately 90% of cases. Individual patient results trended similarly across both markers over time
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Decreased expression of MUC1 is an independent marker for endometrial receptivity in recurrent implantation failure.
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The glycosylation level of CA153 was found to increase with increasing breast cancer stage in the sandwich assay. The assay system appeared to efficiently discriminate breast cancer stage I (sensitivity: 63%, specificity: 69%), IIA (sensitivity: 77%, specificity: 75%), IIB (sensitivity: 69%, specificity: 86%) and III (sensitivity: 80%, specificity: 65%) from benign breast disease.
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High MUC1 expression is associated with cervical cancer.
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KL-6 is an accurate biomarker for the diagnosis of interstitial lung disease in systemic sclerosis.
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MUC1 was a potential molecular target may help explain the role of lincRNA-ROR/miR-145 for invasion and metastasis in Triple-negative breast cancer cell lines.
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We have analysed the tumour-associated carbohydrate antigens sialyl-Lewis x (SLe(x)) and sialyl-Tn (STn) on MUC1 and MUC5AC in Pancreatic adenocarcinoma (PDAC)tissues. immunoprecipitation of MUC5AC from positive PDAC tissues and subsequent SLe(x) immunodetection confirmed the presence of SLe(x) on MUC5AC. Altogether, MUC5AC-SLe(x) glycoform is present in PDAC and can be regarded as potential biomarker.
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High MUC1 expression is associated with breast cancer metastasis.
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These results revealed that serum WFA-sialylated MUC1 was associated with histological features of hepatocellular carcinoma and recurrence after curative therapy.
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this study shows that basaloid squamous cell carcinoma and basal cell carcinoma of the head and neck can be readily distinguished by a limited panel consisting primarily of EMA, and supported by SOX2 and p16
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In the in vitro tests, JFD-WS effectively inhibited HUVEC proliferation, migration, tube formation and VEGFR2 phosphorylation. Additionally, JFD-WS inhibited the formation of blood vessels in chick chorioallantoic membrane. While inhibiting the xenograft tumor growth in experimental mice, JFD-WS decreased the plasma MUC1 levels