Aperçu des produits pour anti-Adenosine A2a Receptor (ADORA2A) Anticorps

Pig (Porcine) Adenosine A2a Receptor (ADORA2A) interaction partners

1. The presence of two different isoforms in the myocardium close to the insertion of pacing is suggestive of a differential state-specific expression of A2AR in cardiac tissue.

2. Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death.

3. Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.

4. Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model.

Horse (Equine) Adenosine A2a Receptor (ADORA2A) interaction partners

1. Activation of adenosine A(2A) receptors inhibited ROS (Montrer ROS1 Anticorps) production by LPS (Montrer IRF6 Anticorps)-stimulated equine neutrophils in a cAMP-dependent manner.

Rhesus Monkey Adenosine A2a Receptor (ADORA2A) interaction partners

1. Adenosine A2A receptor immunoreactivity is localized at the highest levels of the striatum and external globus pallidus.

Zebrafish Adenosine A2a Receptor (ADORA2A) interaction partners

Human Adenosine A2a Receptor (ADORA2A) interaction partners

1. expression A2AR mRNA in PBMCs was associated with asthma severity. Foxp3 (Montrer FOXP3 Anticorps) mRNA, TGF-beta (Montrer TGFB1 Anticorps), and FEV1%pred positively correlated with A2AR mRNA in asthma.

2. This study reported associations between the c.1083T>C polymorphism in the adenosine A2A receptor gene (ADORA2A) and sleep variables

3. Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation has been reported.

4. These data indicate that low [Na(+)] is required to allow large agonist-induced structural changes in A2AR, and that patterns of sidechain dynamics substantially differ between agonist (NECA) and inverse agonist (ZM241385) bound receptors, with the inverse agonist suppressing fast picosecond-nanosecond timescale motions at the G protein binding site.

5. Low adenosine A2a receptor expression is associated with ulcerative colitis.

6. Results demonstrate that A2AR act on GR nuclear translocation and GR-dependent transcriptional regulation which suggest that A2AR is a major regulator of GR function and that this functional interconnection may be a trigger to age-related memory deficits.

7. the present study indicates that A2bR (Montrer ADORA2B Anticorps) may play a potential oncogenic role in BUC progression and act as a potential biomarker to identify BUC patients with poor clinical outcomes.

8. Report prognostic impact of ADORA2A expression in non-small lung cancers.

9. genetic association studies in population in Germany: Data suggest that an SNP in ADORA2A (1976T/C, rs5751876) is associated with interoceptive (resting) and exteroceptive (executive function/task-based) processing in frontal lobe and insular cortex neural networks. Facilitated processing of interoceptive/exteroceptive information in salience network is suggested to promote development of anxiety and anxiety disorders.

10. A2A receptor stimulation promotes collagen type III synthesis via the activation of canonical and non-canonical beta-catenin (Montrer CTNNB1 Anticorps), consistent with a role for A2A receptors in dermal fibrosis and scarring.

Mouse (Murine) Adenosine A2a Receptor (ADORA2A) interaction partners

1. Early synaptic deficits in the APP (Montrer APP Anticorps)/PS1 (Montrer PSEN1 Anticorps) mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.

2. importance for MC5r (Montrer MC5R Anticorps) and A2Ar expression in EAU to promote the induction of protective regulatory immunity, and the expression of MC5r (Montrer MC5R Anticorps) and A2Ar on human immune cells, suggests that it may be possible to utilize the melanocortin-adenosinergic pathways to induce protective immunity in uveitic patients

3. Body weight was significantly smaller in A2AR-KO mice at the age of 6 months

4. A2AR activation enhances its interaction with endothelial glutamate (Montrer GRIN1 Anticorps) transporters. Inhibition of A2AR rescued dysfunction of brain endothelial glutamate (Montrer GRIN1 Anticorps) transporters.

5. The astrocytic Lrp4 (Montrer CORIN Anticorps) plays an important role in ischemic brain injury response. Lrp4 (Montrer CORIN Anticorps) deficiency in astrocytes seems to be protective in response to ischemic brain injury, likely because of the increased ATP release and adenosine-A2AR signaling.

6. the potential effects of the A2A adenosine receptor (A2AR) antagonist SCH (Montrer NF2 Anticorps) 5826 (SCH (Montrer NF2 Anticorps)) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A (Montrer IL17A Anticorps)(+), RORgammat(+), Foxp3 (Montrer FOXP3 Anticorps)(+), and IL-10 (Montrer IL10 Anticorps)(+) in CD4 (Montrer CD4 Anticorps)(+) T spleen cells in BTBR and C57BL/6 (B6) mice, were investigated.

7. Absence of A2AAR increases cochlear resistance to acoustic trauma.

8. Behavioral, anatomical and neurochemical studies to assess psychotic-like symptoms in adult male and female A2AR KO and wild-type littermates. Results bolster the adenosine hypothesis of schizophrenia by demonstrating behavioral and anatomical alterations associated with the specific deletion of adenosine A2AR. These findings resemble most of the relevant phenotype features of the human disorder.

9. Adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK (Montrer EPHB2 Anticorps)/Akt (Montrer AKT1 Anticorps)/HIF-1alpha (Montrer HIF1A Anticorps) pathway.

10. it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 were mediated successively by the PGD2-DP1 receptor, adenosine-A2A receptor, and GABA-GABAA receptor systems downstream of the FPR2.

Rabbit Adenosine A2a Receptor (ADORA2A) interaction partners

1. Study reveals presence of adenosine A(2A) and A(2B (Montrer ADRA2B Anticorps)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.