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anti-Human ARHGEF12 Anticorps:
anti-Mouse (Murine) ARHGEF12 Anticorps:
anti-Rat (Rattus) ARHGEF12 Anticorps:
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xLARG is involved in maintaining the xLARG activation level necessary for the occurrence of epiboly.
Data show that phosphorylation of ribosomal protein S6 kinase 2 (RSK2) at threonine 577 is essential for leukemia-associated RhoGEF (LARG)-dependent Rho GTPase activation.
We studied the function of LARG in murine and human megakaryocytes and platelets with Larg knockout (KO), shRNA-mediated knockdown and small molecule-mediated inhibition. We found that LARG is important for human, but not murine, megakaryocyte maturation.
that leukemia-associated Rho guanine-nucleotide exchange factor can be directly phosphorylated by cyclin-dependent kinase 1
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling.
this study identified a novel association between IOP and ARHGEF12.
TGF-beta regulates LARG and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
LARG is a novel and temporally distinct Rho Guanine Nucleotide Exchange Factor required for completion of abscission.
Data indicate that ICAM-1 signaling activates leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as Rho GEF 12 (ARHGEF12).
Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
RhoGEF activity of p210 BCR/ABL directly contributes to transforming activity, and may account for the difference in disease outcome associated with p190 BCR/ABL and p210 BCR/ABL.
NIS enhanced cell migration and invasion by binding to leukemia-associated RhoA guanine exchange factor
The PDZ domain of LARG is required HRH1-mediated activation of the strictly Rho-dependent transcriptional activity of serum response factor and can be mimicked by activated Galpha(q)(Q209L).
Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).
a novel physical and functional interaction between ABCA1 and PDZ-RhoGEF/LARG, which activates RhoA, resulting in ABCA1 stabilization and cholesterol efflux activity.
Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase
Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated protein and PDZ-RhoGEF.
LARG plays a critical role in plexin-B1 signaling to stimulate Rho activation and cytoskeletal reorganization.
Rho activation through Galpha12 and the regulation of RhoGEFs by heterotrimeric G proteins G1213 is further modulated by tyrosine phosphorylated leukemia-associated RhoGEF.
Data show that different rho guanine nucleotide exchange factors (rhoGEFs; p115rhoGEF, LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and lysophosphatidic acid receptors.
analysis of LARG RhoA binding and nucleotide exchange structure
mechanical activation of RhoA in mesenchymal progenitors is dependent on LARG, while ARHGAP18 limits RhoA delineated cytoskeletal structure in static cultures
Data found an inverse relationship between the expression of miR-660 and ARHGEF12 in both gain- and loss-of-function studies: overexpression of miR-660 declined the mRNA and protein expressions of ARHGEF12 in C2C12 cells differentiation; however, knockdown of miR-660 had completely opposite results.
This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 LARG interaction compared to the Galpha13 activation in the absence of LARG.
LARG may play a housekeeper role in regulating constitutive RhoA activity. Its role in regulating platelet function may principally be through RhoA-independent pathways.
The increase in LARG expression was accompanied by a significant increase in ACh-stimulated Rho kinase and ZIP kinase activities, and sustained muscle contraction
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
RhoGEF12 acts as an integrator of stretch-induced signaling cascades in cardiomyocytes and is an interesting new target for therapeutic intervention in patients with pressure overload-induced heart failure.
LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras
new insight into the mechanism by which p115RhoGEF is activated by Galpha(13).
S1PR2-dependent activation of RhoA in smooth muscle cells is mediated by LARG and that this signaling mechanism promotes the differentiated SMC phenotype.
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA (larg protein)
We demonstrate colocalization of the LARG protein with the IGF-1 receptor, suggesting a potential physiologic role for LARG as an activator of RhoA in response to IGF-1.
mLARG is highly expressed in hematopoietic stem cell fractions, as well as in immature erythroid cells, and provide further support to the hypothesis of the potential involvement of LARG in regulation of early stages of hematopoiesis.
Galpha(12/13) proteins exert essential functions linking extracellular signals to microtubule dynamics and cell polarity via RhoGEF and formin activity.
G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension
IQ-ArfGEF/BRAG1 forms a postsynaptic protein complex containing PSD-95 and NMDA receptors at excitatory synapses, where it may function as a GEF for Arf6.
Rho activation induces mDia1 activity and the latter potentially enables a positive feedback regulatory circuit by promoting LARG-driven activation of Rho and Rho targets such as Rho-associated coiled-coil forming kinase 1 (ROCK).
The immunohistochemically demonstrated that IQ-ArfGEF/BRAG1 was associated with the synaptic ribbons of photoreceptors using both light and electron microscopy. Furthermore, we showed that IQ-ArfGEF/BRAG1 forms a complex with RIBEYE
cDNA of LARG (leukemia-associated guanine nucleotide exchange factor) was identified, and its gene expression was observed to be downregulated under clinorotation, which subsequently resulted in the repression of RhoA activation
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
guanine nucleotide exchange factor
, Rho guanine nucleotide exchange factor (GEF) 12
, rho guanine nucleotide exchange factor 12-like
, leukemia-associated RhoGEF
, leukemia-associated rho guanine nucleotide exchange factor
, rho guanine nucleotide exchange factor 12
, leukemia-associated Rho guanine-nucleotide exchange factor
, leukemia-associated Rho guanine nucleotide exchange factor