Aperçu des produits pour anti-Arhgef9 (Arhgef9) Anticorps

Full name:: anti-Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 Anticorps (Arhgef9)

Chez www.anticorps-enligne.fr sont 62 Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 (Arhgef9) Anticorps de 20 de différents fournisseurs disponibles. De plus, nous expédions Arhgef9 Protéines (5) et et beaucoup plus de produits pour cette protéine. Un total de 74 Arhgef9 produits sont actuellement listés.

Synonymes:: 9630036L12Rik, A230067K14, ARHGEF9, COLLYBISTIN, EIEE8, HPEM-2, mKIAA0424, PEM-2, PEM2, wu:fj33b10

afficher tous les anticorps	Gène	GeneID	UniProt
	Arhgef9	23229	O43307
	Arhgef9	66013	Q9QX73
	Arhgef9	236915	Q3UTH8
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Pathways pertinentes pour anti-Arhgef9 Anticorps

Neurotrophin Signaling Pathway

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Human Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 (Arhgef9) interaction partners

Autism spectrum disorder patient with the smallest inactivating deletion in the collybistin gene.
Collybistin forms a complex with mTOR (Montrer FRAP1 Anticorps) and eIF3 (Montrer EIF3A Anticorps) and by sequestering these proteins downregulates mTORC1 signaling and protein synthesis potentially contributing to intellectual disability and autism.
Impairment of the membrane lipid binding activity of Collybistin R290H and a consequent defect in inhibitory synapse maturation represent a likely molecular pathomechanism of epilepsy and mental retardation in humans.
The enhancement of Cb-induced gephyrin (Montrer GPHN Anticorps) clustering by GTP (Montrer AK3 Anticorps)-TC10 (Montrer RHOQ Anticorps) does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors
Phosphorylation of gephyrin (Montrer GPHN Anticorps) in hippocampal neurons by cyclin-dependent kinase (Montrer CDK1 Anticorps) CDK5 (Montrer CDK5 Anticorps) at Ser (Montrer SIGLEC1 Anticorps)-270 is dependent on collybistin.
Data indicate that ARHGEF9 is likely to be responsible for syndromic X-linked mental retardation associated with epilepsy.
These results reveal that G(s) and G(q) signalings regulate hPEM-2 functions through PKA and c-Src (Montrer SRC Anticorps) in Neuro-2a neuroblastoma (Montrer ARHGEF16 Anticorps) cells, respectively.
major regulator of GABAergic postsynaptic gephyrin (Montrer GPHN Anticorps) clustering
Study propose that the collybistin-gephyrin (Montrer GPHN Anticorps) complex has an intimate role in the clustering of GABA(A)Rs containing the alpha2 subunit.
Here we identified residues critical for interaction with gephyrin (Montrer GPHN Anticorps) in the linker region between the SH3 and the DH domains of collybistin.

Mouse (Murine) Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 (Arhgef9) interaction partners

Results uncover previously unexpected role for CB isoforms downstream of alpha2-containing GABAARs during neuron maturation in a Cdc42 (Montrer CDC42 Anticorps) dependent mechanism.
Within this network, collybistin can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin (Montrer GPHN Anticorps) to plasma membrane phosphoinositides.
data show that collybistin co-clusters with gephyrin (Montrer GPHN Anticorps) and GABA(A) Rs in synaptic puncta and is recruited to postsynaptic specializations early during synapse development; it co-localizes with GABA(A) Rs containing the alpha1, alpha2, or alpha3 subunits
The results of this study provided evidence that the formation of gephyrin (Montrer GPHN Anticorps) scaffolds at inhibitory synapses requires an intact Cb II PH-domain but is Cdc42 (Montrer CDC42 Anticorps)-independent.
The resolution crystal structure of the Cdc42 (Montrer CDC42 Anticorps)-collybistin II complex reveals a novel conformation of the switch I region of Cdc42 (Montrer CDC42 Anticorps), and biochemical data indicate that gephyrin (Montrer GPHN Anticorps) negatively regulates collybistin activity.
Cb is essential for gephyrin (Montrer GPHN Anticorps)-dependent clustering of a specific set of GABA(A) receptors, but not required for glycine receptor (Montrer GLRB Anticorps) postsynaptic localization.
Data provide the first evidence that collybistin deficiency leads to significant changes of GABAergic inhibition, network excitability and synaptic plasticity in vivo.

Arhgef9 profil antigène

Antigen Summary

The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Arhgef9

Cdc42 guanine nucleotide exchange factor 9 (ARHGEF9) anticorps
Cdc42 guanine nucleotide exchange factor (GEF) 9b (arhgef9b) anticorps
Cdc42 guanine nucleotide exchange factor (GEF) 9 (ARHGEF9) anticorps
Cdc42 guanine nucleotide exchange factor 9 (arhgef9) anticorps
Cdc42 guanine nucleotide exchange factor 9 (Arhgef9) anticorps
CDC42 guanine nucleotide exchange factor (GEF) 9 (Arhgef9) anticorps

9630036L12Rik anticorps
A230067K14 anticorps
ARHGEF9 anticorps
COLLYBISTIN anticorps
EIEE8 anticorps
HPEM-2 anticorps
mKIAA0424 anticorps
PEM-2 anticorps
PEM2 anticorps
wu:fj33b10 anticorps

Protein level used designations for Arhgef9

Cdc42 guanine nucleotide exchange factor (GEF) 9 , Cdc42 guanine nucleotide exchange factor 9 , Cdc42 guanine exchange factor 9 , rho guanine nucleotide exchange factor 9-like , PEM-2 homolog , hPEM-2 collybistin , rac/Cdc42 guanine nucleotide exchange factor 9 , rho guanine nucleotide exchange factor 9 , collybistin I , collybistin

GENE ID	SPECIES
422315	Gallus gallus
465666	Pan troglodytes
560923	Danio rerio
100018406	Monodelphis domestica
100054217	Equus caballus
100125033	Xenopus (Silurana) tropicalis
100338091	Oryctolagus cuniculus
100393157	Callithrix jacchus
100512575	Sus scrofa
100586595	Nomascus leucogenys
23229	Homo sapiens
66013	Rattus norvegicus
236915	Mus musculus
100171927	Pongo abelii
537718	Bos taurus

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