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Aperçu des produits pour anti-Arhgef9 (Arhgef9) Anticorps

Full name:: anti-Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 Anticorps (Arhgef9)

Chez www.anticorps-enligne.fr sont 64 Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 (Arhgef9) Anticorps de 21 de différents fournisseurs disponibles. De plus, nous expédions Arhgef9 Protéines (5) et et beaucoup plus de produits pour cette protéine. Un total de 75 Arhgef9 produits sont actuellement listés.

Synonymes:: 9630036L12Rik, A230067K14, ARHGEF9, COLLYBISTIN, EIEE8, HPEM-2, mKIAA0424, PEM-2, PEM2, wu:fj33b10

afficher tous les anticorps	Gène	GeneID	UniProt
	Arhgef9	23229	O43307
	Arhgef9	66013	Q9QX73
	Arhgef9	236915	Q3UTH8
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Pathways pertinentes pour anti-Arhgef9 Anticorps

Neurotrophin Signaling Pathway

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anti-Arhgef9 Anticorps mieux référencés

Human Polyclonal Arhgef9 Primary Antibody pour IHC (p), ELISA - ABIN543513 : Grosskreutz, Hermann, Kins, Fuhrmann, Betz, Kneussel: Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin. dans Biological chemistry 2001 (PubMed)
Show all 3 Pubmed References

Plus d’anticorps contre Arhgef9 partenaires d’interaction

Human Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 (Arhgef9) interaction partners

Autism spectrum disorder patient with the smallest inactivating deletion in the collybistin gene.
Collybistin forms a complex with mTOR and eIF3 and by sequestering these proteins downregulates mTORC1 signaling and protein synthesis potentially contributing to intellectual disability and autism.
Impairment of the membrane lipid binding activity of Collybistin R290H and a consequent defect in inhibitory synapse maturation represent a likely molecular pathomechanism of epilepsy and mental retardation in humans.
The enhancement of Cb-induced gephyrin clustering by GTP-TC10 does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors
Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin.
Data indicate that ARHGEF9 is likely to be responsible for syndromic X-linked mental retardation associated with epilepsy.
These results reveal that G(s) and G(q) signalings regulate hPEM-2 functions through PKA and c-Src in Neuro-2a neuroblastoma cells, respectively.
major regulator of GABAergic postsynaptic gephyrin clustering
Study propose that the collybistin-gephyrin complex has an intimate role in the clustering of GABA(A)Rs containing the alpha2 subunit.
Here we identified residues critical for interaction with gephyrin in the linker region between the SH3 and the DH domains of collybistin.
translocates gephyrin to submembrane microaggregates; collybistin mutation (G55A)is found in exon 2 of the ARHGEF9 gene in a patient with clinical symptoms of both hyperekplexia and epilepsy
Results show that hPEM-2 is a target protein of Smurf1.

Mouse (Murine) Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 (Arhgef9) interaction partners

Collybistin binds the GABAAR-alpha2-subunit with high affinity
Results uncover previously unexpected role for CB isoforms downstream of alpha2-containing GABAARs during neuron maturation in a Cdc42 dependent mechanism.
Within this network, collybistin can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin to plasma membrane phosphoinositides.
data show that collybistin co-clusters with gephyrin and GABA(A) Rs in synaptic puncta and is recruited to postsynaptic specializations early during synapse development; it co-localizes with GABA(A) Rs containing the alpha1, alpha2, or alpha3 subunits
The results of this study provided evidence that the formation of gephyrin scaffolds at inhibitory synapses requires an intact Cb II PH-domain but is Cdc42-independent.
The resolution crystal structure of the Cdc42-collybistin II complex reveals a novel conformation of the switch I region of Cdc42, and biochemical data indicate that gephyrin negatively regulates collybistin activity.
Cb is essential for gephyrin-dependent clustering of a specific set of GABA(A) receptors, but not required for glycine receptor postsynaptic localization.
Data provide the first evidence that collybistin deficiency leads to significant changes of GABAergic inhibition, network excitability and synaptic plasticity in vivo.

Arhgef9 profil antigène

Antigen Summary

The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Arhgef9

Cdc42 guanine nucleotide exchange factor 9 (ARHGEF9) anticorps
Cdc42 guanine nucleotide exchange factor (GEF) 9b (arhgef9b) anticorps
Cdc42 guanine nucleotide exchange factor (GEF) 9 (ARHGEF9) anticorps
Cdc42 guanine nucleotide exchange factor 9 (arhgef9) anticorps
Cdc42 guanine nucleotide exchange factor 9 (Arhgef9) anticorps
CDC42 guanine nucleotide exchange factor (GEF) 9 (Arhgef9) anticorps

9630036L12Rik anticorps
A230067K14 anticorps
ARHGEF9 anticorps
COLLYBISTIN anticorps
EIEE8 anticorps
HPEM-2 anticorps
mKIAA0424 anticorps
PEM-2 anticorps
PEM2 anticorps
wu:fj33b10 anticorps

Protein level used designations for Arhgef9

Cdc42 guanine nucleotide exchange factor (GEF) 9 , Cdc42 guanine nucleotide exchange factor 9 , Cdc42 guanine exchange factor 9 , rho guanine nucleotide exchange factor 9-like , PEM-2 homolog , hPEM-2 collybistin , rac/Cdc42 guanine nucleotide exchange factor 9 , rho guanine nucleotide exchange factor 9 , collybistin I , collybistin

GENE ID	SPECIES
422315	Gallus gallus
465666	Pan troglodytes
560923	Danio rerio
100018406	Monodelphis domestica
100054217	Equus caballus
100125033	Xenopus (Silurana) tropicalis
100338091	Oryctolagus cuniculus
100393157	Callithrix jacchus
100512575	Sus scrofa
100586595	Nomascus leucogenys
23229	Homo sapiens
66013	Rattus norvegicus
236915	Mus musculus
100171927	Pongo abelii
537718	Bos taurus

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Show all anti-Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 (Arhgef9) Anticorps with Pubmed References

Human Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 (Arhgef9) interaction partners

Mouse (Murine) Cdc42 Guanine Nucleotide Exchange Factor (GEF) 9 (Arhgef9) interaction partners

Antigen Summary

Alternative names and synonyms associated with Arhgef9

Protein level used designations for Arhgef9