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Human Polyclonal ITSN1 Primary Antibody pour WB - ABIN261882
Mettlen, Stoeber, Loerke, Antonescu, Danuser, Schmid: Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. dans Molecular biology of the cell 2009
component of Reelin (Montrer RELN Anticorps) signaling that acts predominantly by facilitating the VLDLR (Montrer VLDLR Anticorps)-Dab1 (Montrer DAB1 Anticorps) axis to direct neuronal migration in the cortex and hippocampus and to augment synaptic plasticity
Immunohistochemistry and histological and morphometric analyses revealed a twofold increase in proliferative endothelial cells and a 1.35-fold increase in proliferative alpha-smooth muscle actin (Montrer ACTG2 Anticorps)-positive cells in the lungs of ITSN-deficient mice.
PRRT2 (Montrer PRRT2 Anticorps) interacts with the Src (Montrer SRC Anticorps) homology 3 domain-bearing protein Intersectin 1, an intracellular protein (Montrer CKAP2 Anticorps) involved in synaptic vesicle cycling.
Endocytic deficiency caused by ITSN knock-down modified Alk5 (Montrer TGFBR1 Anticorps) endocytic trafficking and enhances its degradation
It was concluded that miR (Montrer MLXIP Anticorps)-194 regulates ROMK (Montrer KCNJ1 Anticorps) channel activity by modulating ITSN1 expression thereby enhancing ITSN1/WNK-dependent endocytosis.
ITSN1 enhances Cbl (Montrer CBL Anticorps) activity, in part, by modulating the interaction of Cbl (Montrer CBL Anticorps) with Spry2 (Montrer SPRY2 Anticorps) through recruitment of Shp2 (Montrer PTPN11 Anticorps) phosphatase to the Cbl (Montrer CBL Anticorps)-Spry2 (Montrer SPRY2 Anticorps) complex.
This study demonistrated that Itsn1 mutant mice showed severe deficits in Morris water maze and contextual fear memory tasks.
ITSN1 binds Pro-rich regions in both Cbl (Montrer CBL Anticorps) and Spry2 (Montrer SPRY2 Anticorps), and interaction of ITSN1 with Spry2 (Montrer SPRY2 Anticorps) disrupts Spry2 (Montrer SPRY2 Anticorps)-Cbl (Montrer CBL Anticorps) interaction, resulting in enhanced ubiquitylation of the EGFR (Montrer EGFR Anticorps).
Data show that intersectin-SH3D interacts directly with a small region of CdGAP (Montrer ARHGAP31 Anticorps) highly enriched in basic residues and comprising a novel conserved xKx(K/R)K motif.
Swapping of SH3 domain binding partners might act as a switch controlling the actin nucleation activity of intersectin 1L.
study reports that vaccinia virus A36 contains three NPF motifs that interact with the Eps15 (Montrer EPS15 Anticorps) homology (EH) domains in intersectin-1 and Eps15 (Montrer EPS15 Anticorps) to promote the release of virus from infected cells and their subsequent spread
Silencing ITSN1 in neuroblastoma (Montrer ARHGEF16 Anticorps) cells led to decreased tumor growth in an orthotopic mouse model. Orthotopic animal models can provide insight into the role of ITSN1 pathways in neuroblastoma (Montrer ARHGEF16 Anticorps) tumorigenesis.
These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion.
Study suggests critical roles of ITSN1-S in malignant glioma proliferation, indicating a potential usage of ITSN1-S in the therapeutic intervention as a novel molecular target
Our observations suggest that ITSN1 is an important general regulator of Cdc42-, Nck- and N-WASP-dependent actin polymerisation
ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
Silencing ITSN1 significantly inhibits the anchorage independent growth of tumor cells in vitro.
the neuron-specific isoform of the stable tubule-only polypeptide (Montrer MAP6 Anticorps) (STOP) interacts with SH3A domain of ITSN1.
ITSN-1s, via its SH3A domain has the unique ability to regulate dyn2 (Montrer DNM2 Anticorps) assembly-disassembly and function during endocytosis
ITSN1 has two isoforms: ITSN1-long and ITSN1-short. siRNA-mediated down regulation of ITSN1-short inhibits migration and invasion of glioma cells.
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.
, intersectin 1
, intersectin 1, isoform 1
, EH and SH3 domains protein 1
, Eh domain, SH3 domain regulator of endocytosis 1
, intersectin (SH3 domain protein 1A)
, intersectin short form 2 variant 2
, SH3 domain-containing protein 1A
, Src homology 3 domain-containing protein
, human intersectin-SH3 domain-containing protein SH3P17
, intersectin 1 short form variant 3
, intersectin 1 short form variant, 11
, intersectin short variant 12
, EH domain and SH3 domain regulator of endocytosis 1
, intersectin 1 (SH3 domain protein 1A)