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Human Monoclonal MAGED1 Primary Antibody pour WB - ABIN1944790
Wen, Xue, Qin, Yu, Zhang, Zhao, Gao, Gu, Li: hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation. dans FEBS letters 2004
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Mouse (Murine) Monoclonal MAGED1 Primary Antibody pour IC, IF - ABIN2452045
Kuwajima, Nishimura, Yoshikawa: Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
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NRAGE upregulation was correlated with advanced TNM (Montrer ODZ1 Anticorps) stage, local invasion, and poor survival. Importantly, NRAGE could serve as an independent prognostic factor in patients with gastric cancer.
The nuclear localized NRAGE interacts with RNF8 (Montrer RNF8 Anticorps) and BARD1 (Montrer BARD1 Anticorps) to mediate the resistance of esophageal carcinomas cells against DNA-damaging agents.
these results demonstrate the effective anti-autophagic of NRAGE in non-small-cell lung cancer cells through AMPK (Montrer PRKAA1 Anticorps)/Ulk1 (Montrer ULK1 Anticorps)/Atg13 (Montrer ATG13 Anticorps) autophagy signaling pathways. Therefore, NRAGE could be used as a potential therapeutic target for lung cancer.
MAGED1 binds and positively regulates the transcriptional activity of family members SIM1 (Montrer SIM1 Anticorps), SIM2 (Montrer SIM2 Anticorps), NPAS4 (Montrer NPAS4 Anticorps) and ARNT2 (Montrer ARNT2 Anticorps), but does not interact with AhR (Montrer AHR Anticorps), HIF1alpha (Montrer HIF1A Anticorps) and ARNT (Montrer ARNT Anticorps). This interaction is mediated by PAS (Montrer PASK Anticorps) repeat regions which also form the interface for bHLH PAS (Montrer PASK Anticorps) dimerisation, and accordingly MAGED1 is not found in complex with bHLH PAS (Montrer PASK Anticorps) dimers.
our surprise, NRAGE induces nuclear localization of beta-catenin (Montrer CTNNB1 Anticorps) and increases its DNA binding ability. Further studies reveal that NRAGE leads to the modification of beta-catenin/Arm with O-linked beta-N-acetylglucosamine (O-GlcNAc (Montrer OGT Anticorps)), and failure of the association between beta-catenin/Arm and pygopus(pygo) protein, which is required for transcriptional activation of Wnt (Montrer WNT2 Anticorps) target genes. Therefore, our findings suggest a ...
Loss of GSPT2 (Montrer GSPT2 Anticorps) and/or MAGED1 function may contribute to the intellectual disability.
The ectopic subcellular localization of NRAGE mediated nuclear translocation of beta-catenin (Montrer CTNNB1 Anticorps).
High NRAGE expression is associated with esophageal carcinomas.
MAGE-D1 plays important roles in the central nervous system in both developmental and adult stages.
Univariate and multivariate analyses indicated that MAGED1 expression was an independent prognostic factor in colorectal carcinoma
Both transient and stable expression of Necdin (Montrer NDN Anticorps) induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and promoter activation.
MAGED1 as a novel regulator of osteoblastogenesis, osteoclastogenesis, and bone remodeling in a mouse model
Maged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB).
NRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells, which might be via the NF-kappaB (Montrer NFKB1 Anticorps) signalling pathway.
Show Ror2 (Montrer ROR2 Anticorps) expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 (Montrer ROR2 Anticorps) is a potential factor in the tumorigenesis and metastasis in a Src (Montrer SRC Anticorps)-dependent manner that is negatively regulated by NRAGE.
We conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes
Maged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD (Montrer BEST1 Anticorps))
the present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT (Montrer SLC6A4 Anticorps) ubiquitylation.
XIAP (Montrer XIAP Anticorps)-TAB1 (Montrer TAB1 Anticorps)-TAK1 (Montrer NR2C2 Anticorps) complex is dependent on NRAGE for IKK-alpha (Montrer CHUK Anticorps)/beta phosphorylation and NF-kappaB (Montrer NFKB1 Anticorps) activation.
MAGED1 binds to nuclear receptor RORalpha to bring about positive and negative effects on core clock genes of Bmal1 (Montrer ARNTL Anticorps), Rev-erbalpha (Montrer NR1D1 Anticorps) and E4bp4 (Montrer NFIL3 Anticorps) expression through the Rev-Erbalpha (Montrer NR1D1 Anticorps)/ROR responsive elements (RORE).
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.
melanoma antigen family D, 1
, melanoma-associated antigen D1
, melanoma-associated antigen D1-like
, MAGE tumor antigen CCF
, MAGE-D1 antigen
, neurotrophin receptor-interacting MAGE homolog
, sertoli cell necdin-related gene protein 1