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This study solved the structure of a RhoA/Net1 heterodimer with X-ray crystallography at 2-A resolution.
data suggest that NET-1 promotes HCC invasion, adhesion and growth by regulating BAX, caspase 3, caspase 8 and BCL2 expression.
Study found NET1 as a direct target for miR-22 to promote chemoresistance of bladder cancer cells.
We suggest that the oncogenic properties of CML cells are probably due to deregulated expression of NET1 as a result of altered expression of miR-22.
Net1 promotes the angiogenesis in cervical squamous cell carcinomas and siRNA targeting of Net1 can effectively reduce angiogenesis and inhibit tumor growth via VEGF signaling.
AMPK phosphorylation of the RHOA guanine nucleotide exchange factor NET1A inhibits extracellular matrix degradation, an early step in cell invasion
Net1 mRNA and protein levels in non-small cell lung cancer tissues were significantly elevated compared with those in their corresponding nontumor tissues.
Simultaneous silencing of NET-1 and survivin using one-chain-double-target siRNA thus provides an advantageous alternative in the development of therapeutics for skin squamous cell carcinoma .
These data indicate that Net1A acetylation regulates its subcellular localization to impact on RhoA activity and actin cytoskeletal organization.
NET1 was associated with comorbidity of oppositional defiant disorder and symptoms in Attention-deficit/hyperactivity disorder probands
Net1A plays a plays a previously unrecognized, Rho GTPase-independent role in controlling ATM activity and downstream signaling after DNA damage to impact cell survival.
High expression of neuroepithelial transforming gene 1 was associated with hepatocellular carcinoma.
The overexpression of NET-1 in tumor cells may be closely related to the malignant phenotype of skin squamous cell carcinoma including proliferation, invasion and tumor growth.
NET1 expression is elevated in OAC and its pre-malignant phenotype, Barrett's oesophagus. NET1 promotes OAC cell invasion and proliferation.
NET-1 and VEGF silencing play a key role in inhibiting hepatocellular cell proliferation, promoting apoptosis, and reducing angiogenesis.
Results identify Net1 as a novel regulator of mitosis and indicate that altered expression of Net1, as occurs in human cancers, may adversely affect genomic stability.
Data suggests that NET1 may be of prognostic significance in the clinical management of gastric adenocarcinoma
A combination of NET1 (rs2242447) and SNAP-25 (rs3746544) is a risk factor for ADHD.
A previously unrecognized role for the Net1A isoform in controlling FAK activation during planar cell movement.
Rac1 activation causes relocalization of Net1 isoforms outside the nucleus and stimulates Net1A catalytic activity.
These data indicate that Net1 is required for tumor progression in the PyMT mouse model and suggest that Net1 may contribute to breast cancer progression in humans.
Data identify for the first time a role for NET1 in vivo and indicate that NET1 expression is essential for the proliferation and differentiation of mammary epithelial cells in the developing mammary gland.
regulation by nuclear sequestration
NET1 has roles in stimulating cytoskeletal reorganization and in transforming cells
PAK1 negatively regulates the activity of NET1
nuclear Net1 is critical for zebrafish mesendoderm formation and Nodal signal transduction.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
neuroepithelial cell transforming gene 1
, neuroepithelial cell-transforming gene 1 protein
, neuroepithelial cell transforming 1
, Rho guanine nucleotide exchange factor (GEF) 8
, guanine nucleotide regulatory protein (oncogene)
, neuroepithelioma transforming gene 1
, p65 Net1 proto-oncogene protein
, small GTP-binding protein regulator
, Net1 homolog
, rho guanine nucleotide exchange factor 8