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We suggest that the oncogenic properties of CML (Montrer BCR Protéines) cells are probably due to deregulated expression of NET1 (Montrer SLC6A2 Protéines) as a result of altered expression of miR (Montrer MLXIP Protéines)-22.
Net1 (Montrer SLC6A2 Protéines) promotes the angiogenesis in cervical squamous cell carcinomas and siRNA targeting of Net1 (Montrer SLC6A2 Protéines) can effectively reduce angiogenesis and inhibit tumor growth via VEGF (Montrer VEGFA Protéines) signaling.
AMPK (Montrer PRKAA1 Protéines) phosphorylation of the RHOA (Montrer RHOA Protéines) guanine nucleotide exchange factor (Montrer RASGRF1 Protéines) NET1A inhibits extracellular matrix degradation, an early step in cell invasion
Net1 (Montrer SLC6A2 Protéines) mRNA and protein levels in non-small cell lung cancer tissues were significantly elevated compared with those in their corresponding nontumor tissues.
Simultaneous silencing of NET-1 (Montrer SLC6A2 Protéines) and survivin (Montrer BIRC5 Protéines) using one-chain-double-target siRNA thus provides an advantageous alternative in the development of therapeutics for skin squamous cell carcinoma .
These data indicate that Net1A acetylation regulates its subcellular localization to impact on RhoA activity and actin cytoskeletal organization.
NET1 (Montrer SLC6A2 Protéines) was associated with comorbidity of oppositional defiant disorder and symptoms in Attention-deficit/hyperactivity disorder probands
Net1A plays a plays a previously unrecognized, Rho GTPase (Montrer RACGAP1 Protéines)-independent role in controlling ATM (Montrer ATM Protéines) activity and downstream signaling after DNA damage to impact cell survival.
The overexpression of NET-1 (Montrer SLC6A2 Protéines) in tumor cells may be closely related to the malignant phenotype of skin squamous cell carcinoma including proliferation, invasion and tumor growth.
NET1 (Montrer SLC6A2 Protéines) expression is elevated in OAC and its pre-malignant phenotype, Barrett's oesophagus. NET1 (Montrer SLC6A2 Protéines) promotes OAC cell invasion and proliferation.
Data identify for the first time a role for NET1 in vivo and indicate that NET1 expression is essential for the proliferation and differentiation of mammary epithelial cells in the developing mammary gland.
NET1 has roles in stimulating cytoskeletal reorganization and in transforming cells
PAK1 (Montrer PAK1 Protéines) negatively regulates the activity of NET1
nuclear Net1 is critical for zebrafish mesendoderm formation and Nodal signal transduction.
Net1-regulated beta-catenin (Montrer CTNNB1 Protéines) activation plays a crucial role in the dorsal axis formation during zebrafish development.
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
neuroepithelial cell transforming gene 1
, neuroepithelial cell-transforming gene 1 protein
, neuroepithelial cell transforming 1
, Rho guanine nucleotide exchange factor (GEF) 8
, guanine nucleotide regulatory protein (oncogene)
, neuroepithelioma transforming gene 1
, p65 Net1 proto-oncogene protein
, small GTP-binding protein regulator
, Net1 homolog
, rho guanine nucleotide exchange factor 8