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the p-substituted benzyl side chain at N2-position helps to enhance the PDE1 inhibitory profile. Depending on these observations, some new molecules are predicted that may possess better PDE1 inhibition
evidence that the rs182089527 mutation in PDE1A is involved in the development of nephrolithiasis and kidney cysts.
Report significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure and carotid intima-media thickness.
These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis
PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1.
PDE1A is permanently activated in human spermatozoa
Ca2+-calmodulin-dependent phosphodiesterase 1A is activated by sustained entry of Ca2+
PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis.
Variants in PDE1A are not associated with citalopram response in patient with depression.
PDE1A is unlikely to play an important role in antidepressant outcome in this sample
These results support an important role of PDE1A in the renal pathogenesis of autosomal dominant polycystic kidney disease and in the regulation of blood pressure.
These results prove that the kinetic properties of PDE isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2+]i.
new variant PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function.
a novel role for Ca(2+)/CaM-stimulated PDE1, particularly PDE1A, in regulating pathological cardiomyocyte hypertrophy via a cGMP/PKG-dependent mechanism, thereby demonstrating Ca(2+) and cGMP signaling cross-talk during cardiac hypertrophy.
The original finding was the identification and purification of a vinpocetine and muscarinic antagonist-inhibited and CaM-activated plasma membrane-bound PDE1A, linked to M(2)AChR.
Although cAMP regulation by PDE 1 may occur early during capacitation, downstream events appear to prevent full capacitation from occurring prematurely.
analysis of calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) splice variants from bovine cardiac muscle
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1\; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
, calmodulin-activated cyclic nucleotide phosphodiesterase
, phosphodiesterase 1A, calmodulin-dependent
, calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like
, cyclic nucleotide phosphodiesterase 1a
, 61 kDa Cam-PDE
, calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase
, cam-PDE 1A
, 3'-RACE clone 8 phosphodiesterase 1A
, 3-RACE clone 8 phosphodiesterase 1A
, calmodulin-dependent phosphodiesterase type 1
, nucleotide phosphodiesterase, 3'-5'-cyclic