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anti-Human PKC iota Anticorps:
anti-Mouse (Murine) PKC iota Anticorps:
anti-Rat (Rattus) PKC iota Anticorps:
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Human Polyclonal PKC iota Primary Antibody pour IHC (p), WB - ABIN391010
Li, Wang, Liu, Xiao, Lu, Zou: Correlation of aPKC-iota and E-cadherin expression with invasion and prognosis of cholangiocarcinoma. dans Hepatobiliary & pancreatic diseases international : HBPD INT 2008
Show all 3 Pubmed References
Results show a correlation was found between the overexpression of aPKClambda/iota and the degree of pathological differentiation in oral squamous cell carcinoma (OSCC). The nuclear localization of aPKClambda/iota was associated with progression-free survival of OSCC. Overall, the expression and localization of aPKClambda/iota may be involved in the degree of malignancy in OSCC, which is related to prognosis.
We also carried out PKC (Montrer PRRT2 Anticorps)-iota and PKC-zeta (Montrer PRKCZ Anticorps) directed siRNA treatments to prove the above observations. Immunoprecipitation data suggested an association between PKC (Montrer PRRT2 Anticorps)-iota and vimentin (Montrer VIM Anticorps) and PKC (Montrer PRRT2 Anticorps)-iota siRNA treatments confirmed that PKC (Montrer PRRT2 Anticorps)-iota activates vimentin (Montrer VIM Anticorps) by phosphorylation. These results further suggested that PKC (Montrer PRRT2 Anticorps)-iota is involved in signaling pathways which upregulate EMT (Montrer ITK Anticorps) and which can be effectively suppressed using A...
These results indicate that PKCiota/lambda is dispensable for Cdc42 (Montrer CDC42 Anticorps)-triggered processes and for thrombosis and hemostasis in mice.
14-3-3zeta (Montrer YWHAZ Anticorps) and aPKC-iota synergistically facilitate EMT (Montrer ITK Anticorps) of CCA (Montrer FBN2 Anticorps) via GSK-3beta/Snail (Montrer SNAI1 Anticorps) signalling pathway.
In human ovarian cancers, high PRKCI expression correlates with high expression (Montrer TNF Anticorps) of TNFalpha and YAP1 and low infiltration of cytotoxic T cells
promotes epithelial-mesenchymal transition and induces immunosuppression through the aPKC-iota/P-Sp1 (Montrer PSG1 Anticorps)/Snail (Montrer SNAI1 Anticorps) signaling pathway in cholangiocarcinoma
Polarity signaling via CDC42 (Montrer CDC42 Anticorps)/atypical protein kinase C (Montrer PRKCZ Anticorps) can affect the dynamic turnover of the intermediate filament network to promote the polarization of the network itself.
a PI3K (Montrer PIK3CA Anticorps)/PKCiota/cyclin E (Montrer CCNE1 Anticorps) signaling pathway as a therapeutic target during ovarian tumorigenesis
results identify a novel role of PHLPP (Montrer PHLPP1 Anticorps) in regulating aPKC and cell polarity.
the polarity function of PRKCI during cavitation
aPKC regulates apical localization of Lgl1 (Montrer CRISPLD2 Anticorps) and Lgl2 (Montrer LLGL2 Anticorps) to restrict elongation of microridges in developing zebrafish epidermis.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
a loss of zBves affects the proteins involved in the pathway of the PAR (Montrer AFG3L2 Anticorps) junctional complex, especially aPKC, and both aPKC and Bves (Montrer BVES Anticorps) are indispensable to claudin expression.
Heart and soul/PRKCi and nagie oko/Mpp5 (Montrer MPP5 Anticorps) regulate myocardial coherence and remodeling during cardiac morphogenesis (Montrer XIRP1 Anticorps).
PrkCi function and planar divisions are necessary for asymmetric, self-renewing division of spinal cord precursors.
PKClambda/iota emerges as a critical regulator of Th17 differentiation and allergic airway hyperresponsiveness.
This study demonstrated hat (Montrer HAT Anticorps) under physiological conditions, PKCiota/lambda is essential for hippocampal early-LTP (Montrer SCP2 Anticorps) and long-term memory.
the aPKC-CBP (Montrer CREBBP Anticorps) pathway is a homeostatic compensatory mechanism that modulates hippocampal neurogenesis and memory in an age-dependent manner in response to reduced CREB (Montrer CREB1 Anticorps) activity.
he oncogenic activity of PRKCI relates in part to the up-regulation of TNFalpha (Montrer TNF Anticorps) to promote an immune-suppressive tumor microenvironment characterized by an abundance of myeloid-derived suppressor cells and inhibition of cytotoxic T-cell infiltration
Selective deletion of the aPKC isoform Pkc-lambda in proopiomelanocortin (POMC (Montrer POMC Anticorps)) neurons disrupts leptin (Montrer LEP Anticorps) action, reduces melanocortin content in the paraventricular nucleus, and markedly increases susceptibility to obesity, glucose intolerance, and insulin (Montrer INS Anticorps) resistance specifically in HFD-fed male mice.
Prkci and its downstream partners direct polarized cell division of luminal myocardial cells to drive trabeculation in the nascent heart.
Prkci regulates expansion of various stem cells via Notch (Montrer NOTCH1 Anticorps)-dependent pathway.
PKClambda/iota could be a crucial regulator of mitochondrial function and energy metabolism in stem cells and other cellular contexts
Asymmetric division and CD8+ T lymphocyte fate specification is regulated by protein kinase Czeta and protein kinase Clambda.
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
, atypical protein kinase C-lambda/iota
, protein kinase C iota type
, heart and soul protein
, protein kinase C, iota
, protein kinase C iota
, protein kinase C, lambda