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Human Polyclonal RIT2 Primary Antibody pour IP, WB - ABIN233783
Kamura, Koepp, Conrad, Skowyra, Moreland, Iliopoulos, Lane, Kaelin, Elledge, Conaway, Harper, Conaway: Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. dans Science (New York, N.Y.) 1999
Show all 3 Pubmed References
Caenorhabditis elegans (C. elegans) Polyclonal RIT2 Primary Antibody pour EIA, IP - ABIN117958
Furukawa, Zhang, McCarville, Ohta, Xiong: The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. dans Molecular and cellular biology 2000
Show all 14 Pubmed References
Dabrafenib targets B-Raf, and we confirmed a protein-protein interaction between B-Raf and Rit2, which is coded by RIT2, a Parkinson's disease (PD) risk gene in Asians and Caucasians.
RIT2 gene was recently introduced as a susceptibility gene in neurological disorders, a group of major problems in human society affecting millions of people worldwide. Several variants, including single nucleotide polymorphisms and CNVs, have been identified and studied in different populations.
Significant association of RIT2 Polymorphisms was observed between rs12456492 and two disorders, Parkinson's disease and essential tremor
An RIT2 gene variant was found to be a risk factor for autism spectrum disorder in Iranian patients.
Findings indicate for the first time, selective advantage for a human-specific allele at an short tandem repeat locus in the human RIT2 core promoter.
RIT2 rs12456492 do not increase the risk of developing Parkinson's in Han Chinese.
The current meta-analysis suggested that rs12456492 might be associated with increased PD risk in Asian populations, but studies using larger sample sizes and different ethnic populations will be needed to further confirm this association.
findings increase the likelihood of association between Parkinson's disease and RIT2 variant in Asian populations
performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals
Its polymorphism is associated with Parkinson's disease in a Han Chinese population.
The data of this study suggested that the RIT2 polymorphisms are associated with Parkinson disease etiology.
the G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of Parkinson disease. [meta-analysis]
failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for Parkinson's disease in our population.
These studies confirm the expression of RIT2 in retinal neuronal cells.
This meta-analysis identifies a novel Parkinson's disease locus, RIT2, that replicates several previously identified loci on chromosome 18.
Rin interacts directly with dopamine transporter DAT in a protein kinase (PK)C-regulated manner and is required for PKC-mediated DAT internalization.
Modulates the activation of the Brn-3a regulated egr-1 promoter by the N-terminal domain of Brn-3a
Neuron-specific small GTPase Rin is involved in downstream signaling of plexin B3.
observations establish Rin as a neuronal specific regulator of neurotrophin signaling, required to couple NGF stimulation to sustain activation of p38 MAP kinase and b-Raf signaling cascades required for neuronal development
stimulation of PC6 cells with either epidermal growth factor or nerve growth factor (NGF) results in rapid activation of Rin
The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation
Rin and Rit Bind to PAR6 GTP-dependently and regulate cell transformation
RIN belongs to the RAS (HRAS\; MIM 190020) superfamily of small GTPases (Shao et al., 1999
GTP-binding protein Rit2
, GTP-binding protein Roc2
, Ric-like, expressed in neurons
, ras-like protein expressed in neurons
, ras-like without CAAX protein 2
, Ras-like without CAAX 1
, RAS-like protein expressed in neuron
, Ras-like without CAAX 2