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Human Polyclonal HMGA1 Primary Antibody pour IHC, ELISA - ABIN185443
Chiappetta, Botti, Monaco, Pasquinelli, Pentimalli, Di Bonito, DAiuto, Fedele, Iuliano, Palmieri, Pierantoni, Giancotti, Fusco: HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2004
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Human Polyclonal HMGA1 Primary Antibody pour IF, WB - ABIN516550
van der Zee, ten Hagen, Hop, van Dekken, Dicheva, Seynhaeve, Koning, Eggermont, van Eijck: Differential expression and prognostic value of HMGA1 in pancreatic head and periampullary cancer. dans European journal of cancer (Oxford, England : 1990) 2010
Human Polyclonal HMGA1 Primary Antibody pour IF (p), IHC (p) - ABIN736626
Uchikura, Matsubara, Muto, Matsubara, Fujioka, Matsumoto, Sugiyama: Extranuclear Translocation of High-Mobility Group A1 Reduces the Invasion of Extravillous Trophoblasts Involved in the Pathogenesis of Preeclampsia. dans Reproductive sciences (Thousand Oaks, Calif.) 2017
Human Polyclonal HMGA1 Primary Antibody pour ELISA, WB - ABIN451785
Liau, Rocha, Matros, Redston, Whang: High mobility group AT-hook 1 (HMGA1) is an independent prognostic factor and novel therapeutic target in pancreatic adenocarcinoma. dans Cancer 2008
Human Polyclonal HMGA1 Primary Antibody pour FACS, IF - ABIN653050
Mu, Liu, Zhou, Xu, Jiang, Wang, Qu: Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation, invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. dans Human pathology 2010
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Studies define a novel HMGA1-MMP-2 (Montrer MMP2 Anticorps) pathway involved in a subset of human carcinosarcomas and tumor progression in murine models.
Mouse embryonic fibroblasts null for the Hmga1 gene show downregulation of Bub1 (Montrer BUB1 Anticorps), Bub1b (Montrer BUB1B Anticorps), Mad2l1 (Montrer MAD2L1 Anticorps) and Ttk SAC (Montrer ADCY10 Anticorps) genes, and present several features of chromosomal instability, such as nuclear abnormalities, binucleation, micronuclei and karyotypic alterations.
Taken together, our data demonstrate that miR (Montrer MLXIP Anticorps)-625 suppresses cell proliferation and migration by targeting HMGA1 and suggest miR (Montrer MLXIP Anticorps)-625 as a promising prognostic biomarker and a potential therapeutic target for breast cancer.
Inactivation of the Cdkn2a locus cooperates with HMGA1 to drive T-cell leukemogenesis.
Increased HMGA1 expression is associated with pituitary and thyroid tumors.
activated HMGA1 regulates cell proliferation through the Notch1 (Montrer NOTCH1 Anticorps) signaling pathway, which represents an important molecular pathway leading to leukemogenesis.
Data propose that, by affecting the expression of both IGFBP protein species, HMGA1 can serve as a modulator of IGF-I (Montrer IGF1 Anticorps) activity, thus representing an important novel mediator of glucose disposal.
HMGA1 contributes to the neurogenic potential of neural precursor cells in the early stages of neocortical development.
Elevated expression of HMGA1 is associated with the transition of prostate cancer (PCa (Montrer ENPP1 Anticorps)) cells from androgen-sensitive to androgen-independent growth and plays a role in the cell growth of androgen-independent PCa (Montrer ENPP1 Anticorps) cells.
The data in the present study reveal a role of Hmga1 in transcriptional silencing in T cell lineages and leukemic cells.
IL-24 (Montrer IL24 Anticorps) inhibits AKT (Montrer AKT1 Anticorps) via regulating the HMGA1/miR (Montrer MLXIP Anticorps)-222 signaling node in human lung cancer cells and acts as an effective tumor suppressor.
These data reveal an essential role for the molecular chaperone (Montrer HSP90AA1 Anticorps) GRP78 (Montrer HSPA5 Anticorps) in IGF-IR signaling and implicate the use of GRP78 (Montrer HSPA5 Anticorps) inhibitors in blocking IGF-IR signaling in hepatoma cells.
HMGA1 and MMP-11 (Montrer MMP11 Anticorps) may play a key role in the proliferation and progression of skin tumors in humans.
HMGA1 overexpression in adherent A2780 cells increased cancer stem cell properties, including proliferation, spheroid-forming efficiency and the expression of stemness-related genes. In addition, HMGA1 regulated ABCG2 promoter activity through HMGA1-binding sites.
Studies indicate that pseudogenes of the HMGA1 gene, that codes for the HMGA1a and HMGA1b proteins having a critical role in development and cancer progression.
study revealed a subset of potential development-associated miRNAs and suggests a novel regulatory axis for myogenesis in which miR (Montrer MLXIP Anticorps)-195/497 promote myogenic differentiation by repressing the HMGA1-Id3 (Montrer ID3 Anticorps) pathway.
Findings demonstrate that a relationship exists between the HMGA1 rs146052672 variant and acute myocardial infarction, suggesting that defects at the HMGA1 locus may play a pathogenetic role.
SNP rs5498 in ICAM-1 (Montrer ICAM1 Anticorps) gene and IVS5-13insC variant in HMGA1 gene were not associated with the susceptibility of DR in the Chinese T2DM cohort.
We show that the chromatin remodeling protein HMGA1 functions as a downstream effector of these biological responses to miR (Montrer MLXIP Anticorps)-296-5p and regulates Sox2 (Montrer SOX2 Anticorps) expression, a master driver of cell stemness, by modifying chromatin architecture at the Sox2 (Montrer SOX2 Anticorps) promoter
tissue microarray revealed that HMGA1 was expressed in thyroid carcinoma more than that in normal thyroid tissues ; expression of HMGA1 and MMP-2 (Montrer MMP2 Anticorps) was identified to be positively correlated . The present study established the first link between HMGA1 and TGF-b1 in the regulation of thyroid cancer proliferation and invasion
distinct loci exist for growth and fatness in the two populations and identified HMGA1 and PLAG1 (Montrer PLAG1 Anticorps) as strong candidate genes on SSC7 and SSC4, respectively.
Characterization of polymorphisms in the HMGA1 gene in relation to growth and fat deposition.
HMGA1 likely regulates certain aspects of the BoHV-1 latency-reactivation cycle.
This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.
high mobility group protein HMG-I/HMG-Y
, high mobility group protein A1
, high mobility group AT-hook protein 1
, high mobility group AT-hook 1
, high-mobility group (nonhistone chromosomal) protein isoforms I and Y
, high mobility group protein R
, nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y
, high mobility group HMGA1A
, high mobility group HMGA1B
, non-histone protein
, high-mobility group AT-hook 1
, high mobility group protein I
, High mobility group AT-hook protein 1
, High mobility group protein A1
, high mobility group-I protein