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The HNF4gamma whose expression was increased contained two variants.
Results show that HNF4G is a target of miR-122 and that its inhibits proliferation, migration, invasion, and promotes apoptosis of osteosarcoma cell line.
The present data indicates that TT genotype of rs2941484 in the human HNF4G gene might be a gender-specific genetic marker for hyperuricemia in Chinese Han men.
Single nucleotide polymorphisms in HNF4G gene is associated with obesity.
Heterodimerization of HNF4alpha and HNF4gamma was found
2.7 A X-ray crystalography results suggest that the HNF4s may be transcription factors that are constitutively bound to fatty acids
results suggest that the expression level of dihydrodiol dehydrogenase 4 mRNA is cooperatively regulated by the amounts of HNF-1 alpha, HNF-4 alpha and HNF-4 gamma
HNF4A acts redundantly with an intestine-restricted HNF4 paralog, HNF4G, to activate enhancer chromatin and upregulate the majority of transcripts in the differentiated epithelium; cells fail to differentiate on double knockout of both HNF4 paralogs. Furthermore, we show that SMAD4 and HNF4 function via a reinforcing feed-forward loop.
the loss of HNF-4gamma improves glucose homeostasis through a modulation of the enteroendocrine cell lineage.
HNF4g has a role in energy expenditure, locomotor activity during night time, and higher body weight
regulatory role in intramuscular fat deposition
Results show that chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), hepatocyte nuclear factor 4alpha (HNF-4alpha) and HNF-4gamma regulate growth hormone receptor 1A promoter activity through binding to a common DNA element.
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
hepatocyte nuclear factor 4, gamma
, hepatocyte nuclear factor 4-gamma
, nuclear receptor subfamily 2 group A member 2
, hepatocyte nuclear factor 4gamma