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LXRbeta is involved in acute and inflammatory pain.
Data indicate a functional circuit linking PTEN and LXRs, and highlights LXRs as metabolic gatekeepers that are able to constrain prostate cancer (PCa (Montrer ENPP1 Protéines)) progression.
PANDER strongly impacts hepatic lipid metabolism across metabolic states and may induce a selective hepatic insulin resistant phenotype via the LXR pathway.
Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
Wild-type mice and transgenic mice deficient for both alpha and beta Liver X Receptor isoforms were fed a control or an oleate enriched diet; results suggests that dietary oleic acid reduces cholesterolemia while promoting LXR-dependent hepatic lipogenesis without detrimental effects to the liver.
Ativation of LXRbeta increases AQP2 (Montrer AQP2 Protéines) protein levels in the renal collecting ducts via a posttranscriptional mechanism top regulate water electrolyte balance.
EEPD1 is a novel LXR (Montrer NR1H3 Protéines)-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1 (Montrer ABCA1 Protéines).
Saponin-enriched sea cucumber extracts up-regulation hepatic LCR-beta signaling, preventing obesity in mice fed a high-fat diet.
This study showed that although a certain redundancy exists in the functions of liver X receptor alpha (Montrer NR1H3 Protéines) and beta, some physiological processes are more under the influence of only one of them.
these data identify a new mechanism of LXR regulation that involves TIPARP, ADP-ribosylation and MACROD1.
ULK1 (Montrer ULK1 Protéines) has a role in RPS6KB1 (Montrer RPS6KB1 Protéines)-NCOR1 (Montrer NCOR1 Protéines) repression of NR1H/LXR (Montrer NR1H3 Protéines)-mediated Scd1 (Montrer SCD Protéines) transcription and augments lipotoxicity in hepatic cells
These data suggest that high doses of insulin (Montrer INS Protéines) downregulate apoA-I (Montrer APOA1 Protéines) gene expression in HepG2 cells through redistribution of FOXO1 (Montrer FOXO1 Protéines)/LXRbeta complex, FOXA2 (Montrer FOXA2 Protéines), and LXRalpha (Montrer NR1H3 Protéines) on hepatic enhancer of apoA-I (Montrer APOA1 Protéines) gene.
Expression of some LXR-dependent genes of cholesterol trafficking is related to breast tumor characteristics, but not time to recurrence.
a positive association of placental PPARgamma (Montrer PPARG Protéines) mRNA levels and placental DHA levels with baby weight
GW3965 significantly increases the expression of liver X nuclear receptor beta (LXRbeta) mRNA, while the liver X nuclear receptor alpha (LXRalpha (Montrer NR1H3 Protéines)( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB (Montrer NFKB1 Protéines)) activation.
The effects of LXR (Montrer NR1H3 Protéines) agonist on interleukin-8 (IL-8 (Montrer IL8 Protéines)) secretion and nuclear factor-kappa B (NF-kappaB (Montrer NFKB1 Protéines)) activation in human umbilical vein endothelial cells (HUVECs), is reported.
Interactions among SNPs in nucleotide excision repair (NER) genes.
we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis.
These results suggested that 25-HC promoted ADC cell migration and invasion in an LXR-dependent manner in the monoculture system but that in the coculture system, the 25-HC-induced IL-1beta secretion enhanced the effect of 25-HC in an LXR-independent manner.
Protein level of LXRbeta protein was markedly reduced in focal cortical dysplasia.
The liver X receptors, LXRA (NR1H3\; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs\; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009
nuclear receptor subfamily 1, group H, member 2
, LXR beta
, liver X receptor beta
, oxysterols receptor LXR-beta
, retinoid X receptor-interacting protein No.15
, ubiquitously-expressed nuclear receptor 2
, nuclear orphan receptor LXR-beta
, orphan nuclear receptor OR-1
, ubiquitous receptor
, ubiquitously-expressed nuclear receptor
, LX receptor beta
, liver X nuclear receptor beta
, nuclear receptor NER
, steroid hormone-nuclear receptor NER
, nuclear receptor subfamily 1 group H member 2