Profil protéine

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3)

• nuclear receptor subfamily 1 group I member 3 (NR1I3) anticorps
• nuclear receptor subfamily 1, group I, member 3 (Nr1i3) anticorps

• AA209988 anticorps
• AI551208 anticorps
• CAR anticorps
• CAR-beta anticorps
• CAR1 anticorps
• Afficher tous les alias de synonymes
• Care2 anticorps
• CXR anticorps
• ESTM32 anticorps
• MB67 anticorps

Protein level used designations for NR1I3

constitutive androstane receptor , constitutively transactivates RAREs , nuclear receptor subfamily 1 group I member 3 , orphan nuclear receptor MB67 , constitutive androstane receptor NR1I3 , nuclear receptor constitutive active receptor , strain Fischer nuclear receptor (CAR) , constitutive activator of retinoid response , constitutive active receptor , constitutive active response , constitutive androstane nuclear receptor variant 2 , constitutive androstane nuclear receptor variant 3 , constitutive androstane nuclear receptor variant 4 , constitutive androstane nuclear receptor variant 5 , orphan nuclear hormone receptor , xenobiotic receptor