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anti-Mouse (Murine) Vitamin D Receptor Anticorps:
anti-Rat (Rattus) Vitamin D Receptor Anticorps:
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Chemical Polyclonal Vitamin D Receptor Primary Antibody pour IF (p), IHC (p) - ABIN682513
Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats. dans International journal of clinical and experimental pathology 2014
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Chemical Polyclonal Vitamin D Receptor Primary Antibody pour IHC (p), WB - ABIN3043960
Gao, Wang, Yan, Zeng, Ma, Niu, Zhou, Jiang, Chen: Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats. dans PLoS ONE 2016
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Chemical Polyclonal Vitamin D Receptor Primary Antibody pour WB - ABIN3042969
Hou, Huang, Luo, Wang, Liu, Deng, Zhang, Liu, Chen: MiR-351 negatively regulates osteoblast differentiation of MSCs induced by (+)-cholesten-3-one through targeting VDR. dans American journal of translational research 2017
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Dog (Canine) Polyclonal Vitamin D Receptor Primary Antibody pour ELISA, WB - ABIN547464
Malerba, Pignatti: A review of asthma genetics: gene expression studies and recent candidates. dans Journal of applied genetics 2005
Human Monoclonal Vitamin D Receptor Primary Antibody pour DB, WB - ABIN4251062
Momen-Heravi, Masugi, Qian, Nishihara, Liu, Smith-Warner, Keum, Zhang, Tchrakian, Nowak, Yang, Ma, Bowden, da Silva, Wang, Fuchs, Meyerhardt, Ng, Wu, Giovannucci, Ogino, Zhang: Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study. dans International journal of cancer 2017
Chemical Polyclonal Vitamin D Receptor Primary Antibody pour ELISA, WB - ABIN2477107
Cheng, Chen, Huang, Chang, Hung: Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex. dans Journal of cellular biochemistry 2006
Chemical Monoclonal Vitamin D Receptor Primary Antibody pour IHC (p) - ABIN2477108
Ditsch, Toth, Mayr, Lenhard, Gallwas, Weissenbacher, Dannecker, Friese, Jeschke: The association between vitamin D receptor expression and prolonged overall survival in breast cancer. dans The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012
Loss of Cyp27b1-mediated biosynthesis or vitamin D receptor (VDR) function by gene knockdown resulted in significantly reduced runx1 expression and Flk1(+)cMyb(+) HSPC numbers.
zebrafish embryos lacking vdrb produced fewer sensory hair cells in the ears and showed disruption of balance and motor coordination.
Taken together, these results suggest that VDR signaling plays an essential role in heart development.
investigation of binding of ligands that induce significant conformational changes at the protein level
The data suggest that VDR is widely distributed in tissues of the zebrafish, D. rerio, and is likely to play important roles in epithelial transport, bone, and endocrine function.
Recent studies suggest that in in inflammatory bowel diseases the association of VDR single nucleotide polymorphisms with immune and intestinal pathology may be sex dependent. [review]
While further studies are required to determine the mechanisms, by which vitamin D activity regulates osteoclastic bone resorption, our findings suggest that VDR-mediated activity in mature osteoclasts is required to moderate osteoclastic activity during growth and in ovariectomy-induced bone loss.
Our data indicate abnormal osteoclastogenesis due to the absence of Vdr expression, consistent with direct effects of vitamin D signalling being important for regulating the maturation and resorptive activities of osteoclasts.
We conclude that the relative VDR level and the 1,25D availability to cells, are important co-determinants for whether 1,25D plays a promoting or suppressive role in osteoblast-mediated osteogenic activity.
Taken together, our in vivo studies using ChIP-seq analyses and the mini-gene transgenic mice improve our understanding of the tissue-specific regulatory mechanisms of controlling VDR expression and the mechanisms of action of the VDR.
Low VDR expression is associated with epithelial-mesenchymal transition and metastasis in breast cancer.
These findings suggest that Vdr has a cell-intrinsic function in early erythroid progenitors.
Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex.
Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms.
Data suggests that exposure to vitamin D deficiency during perinatal period directly affects expression of genes involved in development of adipose tissue in non-obese offspring; expression levels of Pparg (peroxisome proliferator activated receptor gamma) and Vdr (vitamin D receptor) are up-regulated in adipose tissue of male offspring.
The elevated levels of miR-351 promoted hepatic fibrosis by targeting the vitamin D receptor (VDR), which is an antagonist of SMAD signaling.
the crucial role of VDR in anti-inflammatory effects in lungs
In murine blood cells 1,25-Dihydroxyvitamin D, but not all-trans-retinoic acid, upregulates the expression of VDR.
These findings suggest that the vitamin D treatment-induced increase in bone mass is mediated by suppressing bone resorption through VDR in osteoblast-lineage cells.
Gut epithelial VDR signaling controls mucosal inflammation by suppressing epithelial cell apoptosis.
Expression of VDR exclusively in the distal intestine can prevent abnormalities in calcium homeostasis and bone mineralization associated with systemic VDR deficiency.
Data suggest that the absence of VDR inhibits atherosclerotic plaque calcification in hypercholesterolemic Apoe(-/-) mice, providing additional insight into the role of vitamin D in atherosclerotic plaque calcification.
Activated RAS signaling reduced Vitamin D Receptor (VDR) level in intestinal epithelial cells.
Loss of the vitamin D receptor in macrophages and granulocytes mildly affected colitis-associated symptoms but greatly increased proinflammatory cytokine expression in the inflamed colon, suggesting a prominent role for innate immune cell vitamin D signaling in controlling gut inflammation.
Unique protective roles for vitamin D signaling during colitis in the colon epithelium as well as nonepithelial cells in the colon microenvironment (i.e., modulation of M biology).
Without affecting the expression, conformation, nuclear location of VDR or heteridimerization with RXR, VDR-R343H impairs the transactivation activity of VDR on downstream transcription, accounting for HVDRR features with alopecia.
Among the 4 examined VDR variants, the presence of the minor allele (Ff+ff vs FF) of FokI variant increased the risk for cerebral small vessel disease (SVD) by 1.5-fold in men. Serum 25-hydroxyvitamin D was lower in subjects having the FokI "ff" genotype compared to those with the "FF" genotype. ApaI polymorphism decreased the risk of cerebral SVD in women.
Vitamin D receptor gene single nucleotide polymorphisms rs7975232, rs2228570, and haplotypes TCGC, TTGA are associated with Idiopathic hypocitraturia in a Chinese Bai population.
VDR BsmI gene polymorphism was a risk factor associated with HV, with bb carriers identified as the susceptible population
Study in a group of patients receiving of HLA-matched sibling allogeneic bone marrow transplantation found no association between VDR polymorphisms and graft-versus-host disease (GVHD). Neither was there any impact on survival. Only grade II-IV acute GVHD was associated with inferior overall, but not disease-free survival.
Our results suggest a significant association between severity of chronic periodontitis and Apa1 (rs7975232) and VDBP SNPs (rs7041 and rs4588).
The relationship between p62 and the vitamin D receptor (VDR) was investigated in colorectal cancer. Coimmunoprecipitation assays indicated that p62 interacts with the VDR and may target the NRF2-NQO1 axis.
This study showed that vitamin D receptor gene polymorphism and vitamin D play a role in the control and progression of type 1 diabetes mellitus in children
This meta-analysis of case-control studies revealed that the VDR-FokI polymorphism (F allele) decreased the risk of diabetic retinopathy in Chinese people
Gene expression of VDR in benign prostate epithelium was higher in African Americans compared with European Americans.
Results showed a statistically significant association between genotype frequencies of eNOS gene Glu298Asp polymorphism in sudden sensorineural hearing loss group compared to healthy individuals in the control group (p = .01).
In conclusion, our results suggested that serum 25(OH)D levels and VDR single nucleotide polymorphisms are closely related with cardiovascular disease pathogenesis.
This meta-analysis suggested that VDR rs1544410, rs2228570 and rs731236 variants might serve as genetic biomarkers of tuberculosis in certain populations.
We investigated the association between genetic polymorphisms in VDR, cytochrome P450 (CYP2R1, CYP24A1, and the CYP3A family) with plasma concentrations of vitamin D metabolites (25-hydroxyvitamin D3 (25(OH)D3) and proportion 24,25-dihydroxyvitamin D3 (24,25(OH)2D3)) among individuals of sub-Saharan African and European ancestry. Only CYP3A43 and VDR polymorphisms were associated with proportion 24,25(OH)2D.
demonstrated for the first time that the rs2228570 variant of the VDR gene is associated with Essential Tremor overall and in male patients
Study is the first to describe the A61894G polymorphism, which is in linkage disequilibrium with T61968C, and its association with leprosy occurrence in Brazilian patients. According to analysis, both polymorphisms are closely linked to disease development and study suggests that the combined genotype TCAA favors leprosy susceptibility.
Results show that colorectal cancer (CRC) subjects had lower serum 25(OH)D levels and higher VDR gene expression, and these were negatively correlated in the CRC group. VDR DNA methylation at position 4 had lower levels in the CRC group.
This study investigated specific interactions between vitamin D receptor (VDR) and its ligand. The difference in chirality of ligands causes the difference in Histidine protonations.
Non-obese participants had significantly lower mean VDR gene expression in visceral adipose tissues than both the obese and morbidly obese ones and had also lower expression in subcutaneous adipose tissues than the morbidly obese participants.
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D receptor beta
, vitamin D receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor B
, nuclear receptor subfamily 1 group I member 1-B
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D3 receptor B
, nuclear receptor VDR-b
, vitamin D receptor b
, vitamin D (1,25- dihydroxyvitamin D3) receptor
, 1,25-dihydroxyvitamin D3 receptor A
, nuclear receptor subfamily 1 group I member 1-A
, vitamin D3 receptor A
, Nuclear receptor subfamily 1 group I member 1
, protein phosphatase 1, regulatory subunit 163
, vitamin D nuclear receptor variant 1
, vitamin D receptor protein