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PCSK9 Produits

(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq, Jul 2008].

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Catégories PCSK9 en vedette

PCSK9 Anticorps

High quality antibodies with extensive validation data.

PCSK9 Kits ELISA

Reliable ELISA kits for a wide range of species.

PCSK9 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PCSK9 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (7)
N° du produit ABIN652320
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IF
Validations
  • (6)
N° du produit ABIN6145328
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (5)
N° du produit ABIN7427117
Quantité 100 μL
Fiche technique Fiche technique

PCSK9 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6963307
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6962331
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
  • (3)
  • (1)
N° du produit ABIN6973907
Quantité 96 tests
Fiche technique Fiche technique

PCSK9 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
N° du produit ABIN7275415
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (4)
N° du produit ABIN7275416
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (10)
  • (3)
N° du produit ABIN2181580
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PCSK9

Wang, Amiss, Weidmann, Craik: "Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery." dans: The Journal of biological chemistry, Vol. 295, Issue 34, pp. 12143-12152, (2021) (PubMed).

Burnap, Sattler, Pechlaner, Duregotti, Lu, Theofilatos, Takov, Heusch, Tsimikas, Fernandez-Hernando, Berry, Hall, Notdurfter, Rungger, Paulweber, Willeit, Kiechl, Levkau, Mayr: "PCSK9 Activity Is Potentiated Through HDL Binding." dans: Circulation research, (2021) (PubMed).

Grzegorczyk, Książek, Kurek, Łukaszuk, Rosołowski, Paszko, Krzyżak, Żendzian-Piotrowska: "Effect of Sleeve Gastrectomy on Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Content and Lipid Metabolism in the Blood Plasma and Liver of Obese Wistar Rats." dans: Nutrients, Vol. 11, Issue 9, (2020) (PubMed).

Dalgic, Abaci, Kocas, Cetinkal, Dalgic, Buyuk, Ser, Batit, Arat, Gurmen: "The relationship between protein convertase subtilisin kexin type-9 levels and extent of coronary artery disease in patients with non-ST-elevation myocardial infarction." dans: Coronary artery disease, Vol. 31, Issue 1, pp. 81-86, (2020) (PubMed).

Lebeau, Platko, Al-Hashimi, Byun, Lhoták, Holzapfel, Gyulay, Igdoura, Cool, Trigatti, Seidah, Austin: "Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained." dans: The Journal of biological chemistry, Vol. 293, Issue 19, pp. 7329-7343, (2019) (PubMed).

Elseweidy, Amin, Atteia, El-Zeiky, Al-Gabri et al.: "New Insight on a Combination of Policosanol and 10-Dehydrogingerdione Phytochemicals as Inhibitors for Platelet Activation Biomarkers and Atherogenicity Risk in Dyslipidemic Rabbits: Role of CETP and ..." dans: Applied biochemistry and biotechnology, Vol. 186, Issue 4, pp. 805-815, (2019) (PubMed).

El-Seweidy, Sarhan Amin, Husseini Atteia, El-Zeiky, Al-Gabri: "Dyslipidemia induced inflammatory status, platelet activation and endothelial dysfunction in rabbits: Protective role of 10-Dehydrogingerdione." dans: Biomedicine & pharmacotherapy, Vol. 110, pp. 456-464, (2019) (PubMed).

Chen, Lichtor, Berliner, Chen, Liu: "Evolution of sequence-defined highly functionalized nucleic acid polymers." dans: Nature chemistry, Vol. 10, Issue 4, pp. 420-427, (2019) (PubMed).

Lichtor, Chen, Elowe, Chen, Liu: "Side chain determinants of biopolymer function during selection and replication." dans: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).

Wijers, Zanoni, Liv, Vos, Jäckstein, Smit, Wilbrink, Wolters, van der Veen, Huijkman, Dekker, Kloosterhuis, van Dijk, Billadeau, Kuipers, Klumperman, von Eckardstein, Kuivenhoven, van de Sluis: "The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance." dans: JCI insight, Vol. 4, Issue 11, (2019) (PubMed).

Synonymes et noms alternatifs relatifs à PCSK9

proprotein convertase subtilisin/kexin type 9 (PCSK9), proprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L), proprotein convertase subtilisin/kexin type 9 (pcsk9), proprotein convertase subtilisin/kexin type 9 (Pcsk9), AI415265, AI747682, FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, Narc1, PC9

Protein level used designations for PCSK9

  • convertase subtilisin/kexin type 9 preproprotein
  • neural apoptosis regulated convertase 1
  • subtilisin/kexin-like protease PC9
  • proprotein convertase 9
  • proprotein convertase PC9
  • proprotein convertase subtilisin/kexin type 9
  • proprotein convertase subtilisin/kexin type 9 preproprotein
  • NARC-1
  • convertase subtilisin
  • neural apoptosis-regulated convertase 1
  • Proprotein convertase 9
  • Subtilisin/kexin-like protease PC9
  • LOW QUALITY PROTEIN: proprotein convertase subtilisin/kexin type 9
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