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Human Cathepsin D Kit ELISA pour Sandwich ELISA - ABIN417608
Huber-Lang, Denk, Fulda, Erler, Kalbitz, Weckbach, Schneider, Weiss, Kanse, Perl: Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro. dans Molecular immunology 2012
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Vitner, Dekel, Zigdon, Shachar, Farfel-Becker, Eilam, Karlsson, Futerman: Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses. dans Human molecular genetics 2010
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Li, Lu, Nguyen, Bae, Chapman, Feng, Hawkins, Pessin, Sears, Nguyen, Amidi, Watkins, Nguyen, Olefsky: Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. dans The Journal of biological chemistry 2010
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Schwartz-Roberts, Shajahan, Cook, Wärri, Abu-Asab, Clarke: GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells. dans Molecular cancer therapeutics 2013
Poliakov, Strunnikova, Jiang, Martinez, Parikh, Lakkaraju, Thomas, Brooks, Redmond: Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells. dans Molecular vision 2014
These results suggest that the ecdysone response elements are vital for activation of the promoter by 20-hydroxyecdysone (20E) in the larval fat body and further support the crucial role of ecdysone signaling to control cathepsin D gene transcription.
apoptosis is accompanied by degradation of the cysteine cathepsin inhibitor stefin B (StfB (Montrer CSTB Kits ELISA)). CatD did not exhibit a crucial role in this step. However, this degradation was partially prevented through pre-incubation with the antioxidant N-acetyl cysteine
The lysosomal enzyme cathepsin D (CTSD) mediates the proteolytic cleavage of PSAP (Montrer PSAP Kits ELISA) precursor into saposins A-D. Myc (Montrer MYC Kits ELISA)-CLN3 (Montrer CLN3 Kits ELISA) colocalized with CTSD and activity of CTSD decreased as myc (Montrer MYC Kits ELISA)-CLN3 (Montrer CLN3 Kits ELISA) expression increased, and clearly decreased under hyperosmotic conditions
Study demonstrate that PGRN (Montrer GRN Kits ELISA) interacts with the lysosomal protease CTSD and maintains its proper activity in vivo. Therefore, by regulating CTSD activity, PGRN (Montrer GRN Kits ELISA) may modulate protein homeostasis. This could potentially explain the TDP-43 (Montrer TARDBP Kits ELISA) aggregation observed in frontotemporal lobar degeneration with GRN (Montrer GRN Kits ELISA) mutations.
The S-nitrosation of a non-catalytic cysteine residue in the lysosomal aspartyl protease cathepsin D (CTSD) inhibited proteolytic activation.
Secreted PGRN (Montrer GRN Kits ELISA) is incorporated into cells via sortilin (Montrer SORT1 Kits ELISA) or cation-independent mannose 6-phosphate receptor (Montrer IGF2R Kits ELISA), and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN (Montrer GRN Kits ELISA) levels led to a cell-type-specific increase of insoluble TDP-43 (Montrer TARDBP Kits ELISA). In the brain tissue of FTLD-TDP patients with PGRN (Montrer GRN Kits ELISA) deficiency, CTSD and phosphorylated TDP-43 (Montrer TARDBP Kits ELISA) accumulated in neurons
CTSD, in need of its catalytic activity, may promote proliferation in advanced glycation end products-treated human umbilical vein endothelial cells independent of the autophagy-lysosome pathway.
Cathepsin D facilitates the TRAIL-induced apoptosis of MDA-MB-231 breast cancer cells in enzymatic activity-dependent manner. Caspase-8 (Montrer CASP8 Kits ELISA) and Bid (Montrer BID Kits ELISA) proteins are the CD targets. The modulatory role of CD in cell response to TRAIL was also confirmed in another breast cancer cell line SKBR3.
Gene expression level of CTSD is significantly higher in AD patients when compared to normal controls.
There was a significant difference between groups with and without endothelial dysfunction in terms of cathepsin D levels, and negative and significant correlations were found between brachial artery FMD (Montrer FLNA Kits ELISA)% and cathepsin D levels. Cathepsin D, which is known to be associated with atherosclerosis, may play a role in the proce
Serum CTSB (Montrer CTSB Kits ELISA) and CTSD concentrations were found to have a diagnostic value in NPC (Montrer NPC1 Kits ELISA). However, the CTSB (Montrer CTSB Kits ELISA) and CTSD serum levels had no prognostic role for the outcome in nasopharyngeal carcinoma patients.
These results suggested that Purkinje cells (PCs) were more vulnerable to CTSD deficiency in lysosomes than to autophagy impairment, and this vulnerability does not depend on the severity of axonal swelling.
Exposure of J774A.1 cells to HOCl or HOSCN resulted in a significant decrease in the activity of the Cys (Montrer DNAJC5 Kits ELISA)-dependent cathepsins B and L, but not the Asp (Montrer C3 Kits ELISA)-dependent cathepsin D.
these results suggest that inhibition of lysosomal proteases, such as CtsD, could be a new therapeutic approach to reduce renal fibrosis and slow progression of chronic kidney disease.
The neuroectoderm specific cathepsin D (Ctsd) knock-out mice survived about 5.5 days longer.
Data indicate that cathepsin D (CD) protein is elevated in the retinas of diabetic mice and serum of human patients with diabetic macular edema (DME).
This study demonistrated that Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Post-translational modifications drive CatD into the nucleus to cleave Histone 3 in the involuting mammary gland.
Increased lysosomal storage in CatD KO mice causes oxidative damage in brain pericytes, subsequently resulting in an increased vessel diameter and enhanced permeability of the BBB (Montrer ALMS1 Kits ELISA).
Mouse prolactin (Montrer PRL Kits ELISA) was proteolytically cleaved by Cath D between amino acids 148 and 149. N-terminal prolactin (Montrer PRL Kits ELISA) fragment and Cath D expression increased during mammary gland involution.
Association of polymorphisms in calpain 1 (Montrer CAPN1 Kits ELISA), (mu/I) large subunit, calpastatin (Montrer CAST Kits ELISA), and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle.
findings strongly suggest a link between the lysosomal dysfunction of cathepsin D and the etiology of Alzheimer's disease
The effect of heavy metal cations on the activity of cathepsin D, was studied.
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
, cathepsin D
, aspartic protease
, cathepsin d
, preprocathepsin D
, ceroid-lipofuscinosis, neuronal 10
, lysosomal aspartyl peptidase
, lysosomal aspartyl protease
, cathepsin D (lysosomal aspartyl peptidase)
, cathepsin D (lysosomal aspartyl protease)
, prepro-cathepsin D, prepro-CD