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Human Polyclonal CPA3 Primary Antibody pour IHC, IHC (p) - ABIN4300219
Takabayashi, Kato, Peters, Suh, Carter, Norton, Grammer, Tan, Chandra, Conley, Kern, Fujieda, Schleimer: Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps. dans The Journal of allergy and clinical immunology 2012
Carboxypeptidase A3 was differentially expressed between Fibromyalgia patients and healthy controls.
Urine CPA3 was increased in patients with chronic prostatitis/chronic pelvic pain syndrome compared to controls.
The cDNA encoding human colon mast cell carboxypeptidase can be successfully cloned and expressed in E. coli and P. pastoris.
Role in regulating innate immunity responses and regulating secretory granule homeostasis
The goal of the current study was to compare bone repair in normal wild type and Cpa3Cre/+ mice, which lack mast cells in the absence of any other hematopoietic or non- hematopoietic deficiencies. Mast cells appear in healing bone of wild type mice but not Cpa3Cre/+ mice, beginning 14 days after surgery. Re-vascularization of repair tissue and deposition of mineralized bone was delayed and dis-organised in Cpa3Cre/+ mice
Mast cells in experimental arthritis contained high levels of mMC-CPA mRNA, and also lacked the exopeptidase.
Data suggest that carboxypeptidase A3 (Cpa3)-Cre; myeloid cell leukemia sequence 1 (Mcl-1)(fl/fl) mice may be useful in analyzing the roles of mast cells and basophils in health and disease.
mast cell chymase and CPA have key roles in both the generation and degradation of Ang II
cathepsin E is located in mast-cell secretory granules in complex with heparin proteoglycans, and has a role in the processing of procarboxypeptidase A into active protease
Mc-cpa plays a crucial role for the generation of phenotypically mature mast cells.
Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a form which is obtained as a binary complex of a procarboxypeptidase A with proproteinase E and functions as a secretory granule metalloexopeptidase.
mast cell carboxypeptidase A
, tissue carboxypeptidase A
, LOW QUALITY PROTEIN: mast cell carboxypeptidase A
, carboxypeptidase A3 (mast cell)