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NDR2 (Montrer STK38L Protéines)-mediated Rabin8 phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of Rabin8 from PS to Sec15.
coordinated disruption of the Rab11 (Montrer RAB11A Protéines)/Sec15 exocyst by anthrax toxins may contribute to toxin-dependent barrier disruption and vascular dysfunction during B. anthracis infection
Sec15 has a role as an effector for the Rab11 GTPase (Montrer RAB11A Protéines) in mammalian cells
The SEC15 protein plays a crucial role in integrating the signals between Sec4p and the components of the early-polarity-establishment machinery.
These results suggest that the association of Rab10 (Montrer RAB10 Protéines)-GTP (Montrer AK3 Protéines) with Exoc6/6b is a molecular link between insulin (Montrer INS Protéines) signaling and the exocytic machinery in GLUT4 (Montrer SLC2A4 Protéines) translocation.
Mutation in Sec15l1 causes anemia in hemoglobin deficit mice.
Iron metabolism mutant hbd mice have an exon deletion in Sec15l1.
These data indicate that rapid transferrin (Montrer Tf Protéines) recycling is defective after pSec15l1 has mutated.
Exoc3l (Montrer EXOC3L1 Protéines) is involved in regulated exocytosis of insulin (Montrer INS Protéines) granules; expressed in insulin (Montrer INS Protéines)-secreting cells as well as in various tissues including pancreatic islets and brain.
The Sec15 protein, a known Rab11 (Montrer RAB11A Protéines) effector and a component of the exocyst, is necessary for Notch (Montrer NOTCH1 Protéines) activation and the resolution of distinct sibling cell fates in the sensory organ precursors lineage.
In fly photoreceptors Sec15 colocalizes with Rab11 (Montrer RAB11A Protéines) and that loss of Sec15 affects rhabdomere morphology.
The product of this gene belongs to the SEC15 family. It is highly similar to the protein encoded by Saccharomyces cerevisiae SEC15 gene. This protein is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
, SEC15-like protein 1
, exocyst complex component Sec15A
, SEC15-like protein 3
, SEC15 homolog
, exocyst complex component 6
, Exocyst complex component Sec15A