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The pituitary hormone Fsh promoted the formation of type A undifferentiated spermatogonia and Sertoli cells by stimulating Leydig cell production of the non-canonical Wnt ligand Wnt5a.
Action of Lh and Fsh signaling is redundant in that either alone can support zebrafish spermatogenesis.
FSH-deficient zebrafish (fshb(-/-)) were surprisingly fertile in both sexes; however, the development of both the ovary and testis was significantly delayed.
zfFSHbeta promoter responded to 6h of gonadotropin-releasing hormone treatment by activating calcium influx and protein kinase C (PKC), but after 24h, GnRH induction was generated by activation of extracellular-regulated kinase 1/2 and repression by PKC.
LHbeta and LH-R mRNA expression might be involved in initial maturation events of gametes, at least in males, while the gradually increase of FSH-R mRNA coincided with the advancing process of gamete maturation in both sexes
A major regulatory mechanism for FSH glycosylation involves control of beta-subunit N-glycosylation, possibly by inhibition of oligosaccharyl transferase. Two primate species exhibited the same all-or-none pattern of pituitary FSHbeta glycosylation.
Our current findings show that elevated FSH had minimal disruption of either embryo developmental capacity or uterine function when examined in isolation, and the subfertility of TgFSH female mice was not caused by altered oocyte aneuploidy or quality.
FSH enhances CRTC2-mediated gluconeogenesis dependent on AMPK Ser485 phosphorylation via GRK2 in the liver, suggesting an essential role of FSH in the pathogenesis of fasting hyperglycaemia
FSH induces autophagy via upregulation of HIF-1A in mouse granulosa cells.
the in vivo bioactivities of FSH glycoforms in Fshb null mice using a pharmacological rescue approach, was investigated.
These mice showed an increase in FSH levels, but they remained in a prepubertal state. Together with previous findings, our data indicate that leptin-selective action in gonadotropes serves a role in adult reproductive physiology but is not sufficient to allow pubertal maturation in mice.
GnRH stimulated the secretion of the VGF-derived peptide NERP1. NERP1 caused a concentration-dependent decrease in Fshb gene induction.
the signaling pathways mediating GnRH activation of CREB and ICER are distinct, contributing to the decoding of the pulsatile GnRH to regulate FSHbeta expression.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb), follicle stimulating hormone beta (Fshb), and intracellular adhesion molecule-5 (Icam5) in females but only decreased expression of Icam5 in males.
GnRH stimulation of Fshb expression is dependent on miR-132/212 and involves a SIRT1-FOXO1 pathway.
results suggest that FOXO1 binding to the proximal Fshb promoter as well as FOXO1 interaction with SMAD3/4 proteins may result in decreased activin induction of Fshb in gonadotropes
SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe.
Data suggest that the BMP2-like Activin A/BMP2 chimera AB215 regulates follicle stimulating hormone beta (FSHbeta) induction in LbetaT2 gonadotroph cells due to its ability to block activin A signaling.
Two regions of the proximal Fshb promoter (-50/-41 and -30/-21) appear to be necessary for FOXO1 suppression of GnRH-induced Fshb transcription.
Data suggest BMP2 (bone morphogenetic protein 2) stimulates SMAD2/3 signaling in gonadotrophs via Bmpr1a (bone morphogenetic protein receptor type 1A); such signaling via SMAD3 appears to be necessary for up-regulation of Fshb transcription.
The activin A signals via SMAD proteins, but not TAK1 or p38, to regulate murine and ovine Fshb transcription in gonadotrope-like cells.
The insulin/IGF signaling pathway is required for FSH-mediated Sertoli cell proliferation.
FOXL2 is required for FSH synthesis in vivo.
A PKA-mediated signaling pathway mediates GnRH activation of CREB at low-pulse frequencies, playing a significant role in the decoding of the hypothalamic GnRH signal to result in frequency-dependent FSHbeta activation.
Data indicate that free fatty acids up-regulated luteinizing hormone beta (Lhb) mRNA expression acutely but suppressed follicle stimulating hormone beta (Fshb) mRNA expression.
findings indicate the expression of Brms1L depends on beta-catenin activity and contributes to follicle stimulating hormone beta induction by Gonadotropin-Releasing Hormone.
nonsense mutation (c.343C > T:p. Arg115Stop) in exon 3 caused failure of onset of puberty
The wild-type allele G was found in 86.4% and the polymorphic allele T in 13.6% of the women respectively. Women carrying the GT genotype had a poorer response more frequently to controlled ovarian hyperstimulation when compared to individuals with the GG genotype, higher LH levels, lower AFC), oocytes retrieved and embryos.
We propose that like in men, also in women the FSHB -211 G>T represents a key genetic modulator of circulating gonadotropin, leading to various possible downstream effects on reproductive physiology.
High follicle stimulating hormone expression is associated with Turner syndrome.
We found a genetic association between rs11031006 (FSHB) SNP and endometriosis. WNT4 and VEZT genes constitute the most consistently associated genes with endometriosis. In the present study, an association of rs7521902 (WNT4) and rs10859871 (VEZT) was confirmed in women with endometriosis at the genotypic but not the allelic level.
Genetic variation affecting FSH production (FSHB c.-211G>T) was associated with age at pubertal onset, as assessed by testicular enlargement. The effect appeared further modified by coexistence of genetic variation affecting FSH sensitivity (FSHR c.-29G>A).
A novel homozygous mutation in the FSHbeta gene (c.343C > T) identified in a male patient with isolated FSH deficiency and infertility.
Association of the FSHB 211G > T polymorphism with male infertility in Han-Chinese
Genetic variations of FSH signaling appear to determine the individual set point of the hypothalamic-pituitary-gonadal axis already early in life.
Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency
Variants in FSHB gene are associated with polycystic ovary syndrome and LH levels in Han Chinese women.
Data indicate that compared with normal eggs, oocytes with a brown zona pellucida (ZP) were found to have a higher ZP thickness (ZPT), lower embryo quality and lower pregnancy rate, which might be due to a high gonadotropin (Gn) dosage injection and high serum follicle stimulating hormone (FSH) levels.
genetic association studies in peripubertal girls in Denmark: Data suggest that an SNP in FSHR (follicle stimulating hormone receptor, c.2039A>G) is associated with blood levels of FSH, LH, and estradiol; minor alleles in FSHB (follicle stimulating hormone beta subunit, c.-211G>T) and FSHR (c.-29G>A) are associated with delayed pubertal onset.
The FSHB -211G>T variant attenuates serum FSH levels in the supraphysiological gonadotropin setting of Klinefelter syndrome
3 known FSH-action modulating SNPs (FSHB -211G/T; FSHR -29G/A, c.2039 A/G)explained together 2.3%, 1.4%, 1.0 and 1.1% of the measured variance in serum FSH, Inhibin B, testosterone and total testes volume, respectively.
The combined effect of FSHB GG+FSHR AA may potentiate the FSH pathway, which increases serum levels of FSH and reduces antimullerian hormone in health girls.
Serum FSH levels are affected by the combination of genetic polymorphisms in FSHR and FSHB
Data suggest that low serum FSH levels in men with an SNP in promoter region of FSHB (-211G/T) result from reduced binding of LHX3 (LIM homeobox 3) to FSHB promoter/response element and down-regulation of FSHB transcription in gonadotrophs.
activin-regulated transcription mediated by forkhead box L2 [review]
Study describes generation and characterization of a new Fshb-iCre deleter strain using 4.7 kb of ovine Fshb promoter sequences driving iCre expression exclusively in the gonadotrope lineage with mice developing normally, and fertile.
the novel cis-regulatory element generated by the c.-1539_-1538delGGinsTTAACT mutations might play an important role in repressing FSHB transcription, possibly leading to reduced fertility
A 200-base region in the bovine FSHbeta 3' untranslated region downregulates reporter expression at the translational level via interactions between AREs in both the 3'UTR and transfactors.
The shift in FSH isoforms toward a greater abundance of the less acidic isoforms appears to be a key component in determining the capability for producing a preovulatory rise in estradiol.
The effect of a single nucleotide polymorphism of the follicle stimulating hormone beta chain on bull fertility and semen quality is reported.
As in vitro experiments in the present study suggested that LHX2 regulated the expression of Fshbeta, it is possible that LHX2 controls FSH synthesis at the transcriptional level.
Results showed that the effects of FSHb, ESR, and PRLR genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
LHX3 LIM homeodomain transcription factor is involved in activation of the FSH beta-subunit gene in the pituitary gonadotrope cell.
Prop-1 participates in the regulation of FSHbeta gene
A allele of FSHbeta-1 locus in all the population and FSHbeta-2 locus in pigs of the first parity had the positive effective on TNB, NBA, and WB.
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.
, Gth I
, follicle-stimulating hormone beta subunit
, follitropin subunit beta
, FSH beta
, follcle-stimulating hormone beta subunit
, follicle stimulating hormone, beta polypeptide
, follitropin beta chain
, Follicle-stimulating hormone beta subunit
, follicle stimulating hormone beta-subunit
, follitropin, beta chain
, follicle - stimulating hormone subunit beta
, follicle stimulating hormone beta
, follicle-stimulating hormone beta-subunit
, follicle-stimulating hormone subunit beta
, class 1 follicle-stimulating hormone beta polypeptide
, class 2 follicle-stimulating hormone beta polypeptide
, follicule stimulating hormone, beta polypeptide
, follicle stimulating hormone beta subunit
, follitropin beta subunit