Aperçu des produits pour PCSK1 Protéines (PCSK1)

Human Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

1. we found eight known variants and two novel heterozygous variants (c.1095 + 1G > A and p.S24C), and identified and functionally characterized two rare novel PCSK1 variants of which c.1095 + 1G > A caused complete loss of protein function. In addition to confirming rs6232 and rs6234 in PCSK1 as polygenic risk variants for childhood obesity, we describe an association of rs725522 with insulin (Montrer INS Protéines) metabolism.

2. investigation of the pathogenesis of obesity in the PC1/3-N222D mouse model and whether this molecular mechanism also applies to common and rare human PCSK1 mutations

3. PCSK1 deficiency plays a role in human endocrinopathies, obesity, gastrointestinal disorders.

4. findings suggest that the major neuroendocrine features of Prader-Willi syndrome are due to PC1 deficiency

5. PCSK1 mutations are associated with Obesity.

6. PCSK1 expression is significantly upregulated in human masticatory mucosa during wound healing

7. these common variants in PCSK1 and POMC (Montrer POMC Protéines) were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 did affect cholesterol level, LDL-C level, and waist circumference.

8. we demonstrate evidence that common gene variation in PCSK1 contributes to BMI variation and susceptibility to common obesity in the largest known meta-analysis published to date in genetic epidemiology.

9. Data show that prohormone convertase 1/3 (PC1/3) endoplasmic reticulum-retained mutants induce endoplasmic reticulum stress.

10. Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

1. Study reveals a significant reduction of tachykinin and opioid neuropeptides level in proprotein convertase 1 and proprotein convertase 2 (Montrer PCSK2 Protéines) mutant mouse spinal cords.

2. Oxygen and glucose deprivation or middle cerebral artery occlusion stress caused substantial cell death in a dose-dependent manner. With the increasing OGD (Montrer FGFR1 Protéines) dose, proPC1 and PC1 proteins gradually increased. In vivo the proPC1 and PC1 expressions presented with a peak at 4-h and then decreased at 24-h reperfusion. The results suggest that the increasing PC1 expression promoted the transformation of proCgA into CgA (Montrer CGA Protéines) or small

3. investigation of the pathogenesis of obesity in the PC1/3-N222D mouse model and whether this molecular mechanism also applies to common and rare human PCSK1 mutations

4. These pathways are consistent with previously reported behavioral and biochemical phenotypes that typify mice lacking ENT1 (Montrer SLC29A1 Protéines). Moreover, we validated decreased expression of the SNARE (Montrer VTI1B Protéines) complex protein VAMP1 (synaptobrevin-1 (Montrer VAMP1 Protéines)) in the dHip as well as decreased expression of pro-dynorphin (PDYN (Montrer PDYN Protéines)), neuroendocrine convertase (PCSK1), and Leu-Enkephalin (dynorphin-A (Montrer PDYN Protéines)) in the nucleus accumbens

5. findings suggest that the major neuroendocrine features of Prader-Willi syndrome are due to PC1 deficiency

6. macrophages from PC1/3 KO mice and rat PC1/3-KD NR8383 macrophages secreted more pro-inflammatory cytokines such as TNF-alpha (Montrer TNF Protéines), IL6 (Montrer IL6 Protéines), IL1alpha (Montrer IL1A Protéines) and CXCL2 (Montrer CXCL2 Protéines).

7. PC1 and PC2 (Montrer CBX4 Protéines) are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 (Montrer TAC1 Protéines) protein

8. Binding of MAGP2 (Montrer MFAP5 Protéines) to microfibrils is regulated by proprotein convertase cleavage.

9. Data indicate that the mutant PC1/3-N222D protein coimmunoprecipitates with wildtype(WT) prohormone convertase 1/3 (PC1/3) and exerts a modest effect on intracellular retention of the WT enzyme.

10. proSAAS (Montrer PCSK1N Protéines) as a novel down-regulated target of Pax6 (Montrer PAX6 Protéines)

Cow (Bovine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

1. Prohormone convertase PC1 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.

2. a model of the membrane topology of the prohomone convertase PC3, where it is anchored to lipid rafts in secretory granule membranes via the transmembrane domain

Zebrafish Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

1. Pcsk1 has been sequenced and characterized.

Pig (Porcine) Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) interaction partners

1. Study identified 14 polymorphisms that were organized in nine haplotypes, clearly distributed in two clades of putative European and Asian origin and showed that the porcine PCSK1 gene is associated with fat deposition.