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Unc-51 Like Kinase 1 (ULK1) (N-Term) Peptide

ULK1 Reactivité: Humain Hôte: Synthetic BP, WB
N° du produit ABIN2184424
  • Antigène Tous les produits ULK1
    ULK1 (Unc-51 Like Kinase 1 (ULK1))
    Protein Region
    N-Term
    Origine
    Humain
    Source
    • 1
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Séquence
    PEVIMSQHYD GKADLWSIGT IVYQCLTGKA PFQASSPQDL RLFYEKNKTL
    Attributs du produit
    This is a synthetic peptide designed for use in combination with anti-ULK1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Conseil sur la manipulation
    Avoid repeat freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Antigène
    ULK1 (Unc-51 Like Kinase 1 (ULK1))
    Synonymes
    ATG1 Peptide, ATG1A Peptide, UNC51 Peptide, Unc51.1 Peptide, hATG1 Peptide, si:dkey-11o18.7 Peptide, ulk1 Peptide, ULK1 Peptide, AU041434 Peptide, mKIAA0722 Peptide, zgc:195008 Peptide, unc-51 like autophagy activating kinase 1 Peptide, unc-51 like kinase 1 Peptide, unc-51 like autophagy activating kinase 1a Peptide, ULK1 Peptide, Ulk1 Peptide, ulk1b Peptide, ulk1a Peptide
    Sujet
    ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.

    Alias Symbols: ATG1, ATG1A, UNC51, Unc51.1, hATG1

    Protein Size: 1050
    Poids moléculaire
    112 kDa
    ID gène
    8408
    NCBI Accession
    NM_003565, NP_003556
    UniProt
    O75385
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