A synthetic peptide for use as a blocking control in assays to test for specificity of TYMS antibody, Alternative Names: TYMS control peptide, TYMS antibody Blocking Peptide, Anti-TYMS Blocking Peptide, Thymidylate Synthetase Blocking Peptide, HsT422 Blocking Peptide, MGC88736 Blocking Peptide, TMS Blocking Peptide, TS Blocking Peptide, TSase Blocking Peptide
TYMS catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.