E-cadherin (CDH1)
(Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
Protein Region
Middle Region
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Attributs du produit
This is a synthetic peptide designed for use in combination with anti-CDH1 antibody (Catalog #: ARP51289_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Protein Interaction Partner: ZEB1,CAV1,CTNNB1,CTNNB1,CTNNB1,CTNND1,EGFR,ACTR3,ANAPC7,ARHGAP32,ARVCF,CA9,CASP3,CASP8,CBLL1,CDH1,CSE1L,CSNK2A1,CTNNA1,CTNNB1,CTNND1,CTNND2,EGFR,ERBB2IP,EZR,GNA12,GNA13,GSK3B,HDAC1,HDAC2,IQGAP1,IRS1,ITGAE,ITGB7,JUP,NDRG1,NEDD9,PKD1,PPP1CA,PSEN1,PTPN14,PTPRF,PTPRM,RAB8B,RRM2,VCL,ACTG1,ACTN1,AJAP1,ANAPC1,ANAPC11,ANAPC4,ANAPC7,APC2,ARPC2,BOC,CA9,CBLL1,CDC16,CDC23,CDC26,CDC27,CDH1,CDH3,CDON,CSE1L,CTNNA1,CTNNB1,CTNND1,EGFR,EZR,FER,FOXM1,FYN,GNA12,GNA13,HDAC1,HDAC2,IQGAP1,ITGAE,JUP,MAD2L2,MAGI1,MDM2,MET,MYO7A,NEDD9,PKP4,PSEN1,RAB8B,SRC,UBC,VCL,VEZT,YES1