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Paired Immunoglobin-Like Type 2 Receptor beta (PILRB) Peptide

PILRB Reactivité: Humain Hôte: Synthetic BP, WB
N° du produit ABIN981766
  • Antigène Tous les produits PILRB
    PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))
    Origine
    Humain
    Source
    • 1
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Attributs du produit
    This is a synthetic peptide designed for use in combination with anti-PILRB antibody (Catalog #: ARP46949_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Indications d'application
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Antigène
    PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))
    Synonymes
    FDFACT1 Peptide, FDFACT2 Peptide, FDFACT Peptide, Fdact Peptide, Pilrb Peptide, paired immunoglobin-like type 2 receptor beta Peptide, paired immunoglobin-like type 2 receptor beta 1 Peptide, PILRB Peptide, Pilrb1 Peptide, Pilrb Peptide
    Sujet
    Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.

    Alias Symbols: FDFACT1, FDFACT2

    Protein Interaction Partner: BAT5,LYN,PTPN11,PTPN6,SAMSN1

    Protein Size: 227
    Poids moléculaire
    23 kDa
    ID gène
    29990
    NCBI Accession
    NM_013440, NP_038468
    UniProt
    Q9UKJ0
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