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anti-Mouse (Murine) PER1 Anticorps:
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Rat (Rattus) Polyclonal PER1 Primary Antibody pour WB - ABIN549001
Kume, Zylka, Sriram, Shearman, Weaver, Jin, Maywood, Hastings, Reppert: mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. dans Cell 1999
Show all 5 Pubmed References
endogenous CLOCK is essential for the transcriptional regulation of period1 in the embryo
PER1 mediates control of circadian blood pressure rhythms via the regulation of distal nephron Na transport genes.
The studies demonstrate that the Per1, Per2, and Par3 genes are not necessary for the expression of food anticipatory activity in mice.
TRAF2 modulates the maximal Per1 mRNA level of the circadian clock.
Autonomous clock in the rostral and caudal part of the habenula requires integrity of circadian genes Per1/2 to tick, and light information or suprachiasmic nuclei innervation to keep synchrony.
Study shows abnormal circadian locomotor rhythms and Per1 and Per 2 gene expression in six-month-old triple transgenic mice model of Alzheimer's disease.
hippocampal Per1 is critical for long-term memory formation.
Period genes not only orchestrate dynamic changes in metabolic activity, but also regulate homeostatic self-renewal of hepatocytes through Mkp1-Erk1/2 signaling pathway.
Results show that Per1 expression is associated with a short period and Per2 expression is associated with a long period and, that Per1 and Per2 cooperatively confine the range of circadian period length to approximately 24-h.
This vitro data suggests that basal activity of autophagy seems to be modulated by PER1, and confirms the in vivo data by showing that the autophagic machinery is depressed in Per1-/--hippocampal neurons.
These findings indicate that the expressions of two key clock genes, Per1 and Bmal1, in the SCN are regulated in such a way that they may adopt different phases and free-running periods relative to each other and are respectively associated with the expression of activity onset and offset.
we elucidate the dual functions of PER as repressor and de-repressor in a context-dependent manner.
Atxn2(-/-) mice showed an unstable rhythmicity of locomotor activity, but the level of PER1 and PER2 IR in the SCN did not differ between genotypes.
In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1(-/-) ) mice (right) the kinase is trapped at the nuclear periphery
beta-amyloid protein (31-35) altered the expression of the Per1 and Per2 in the suprachiasmatic nucleus, hippocampus and heart. These findings provide experimental evidence for circadian rhythm disturbances in patients with Alzheimer's disease.
In vivo knockdown of Rfk, Riboflavin (vitamin B2) kinase essential for FAD synthesis, altered the expression rhythms of CRY1, CRY2, and PER1
these data support an important role for the circadian clock protein PER1 in the modulation of blood pressure in a high salt/mineralocorticoid model of hypertension
Per1 knockdown leads to JNK phosphorylation, CCL2 production and allodynia.
Deletion of Per1 alleviated the inhibitory effect of PPAR-gamma on CC chemokine receptor 2 expression, resulting in enhanced macrophage recruitment into the liver.
Rate-limiting mitochondrial enzymes that process lipids and carbohydrates accumulate in a diurnal manner and are dependent on the clock proteins PER1/2. Diurnal regulation of mitochondrial respiration was blunted in PER1/2 knockout mice.
that the presence of a depressive state around the early active phase of activity may be related to impairment of rhythmicity and expression levels of Per1 and Per2 genes under abnormal light-dark conditions
These data together suggest that Per-1 is a novel negative regulator of HIV-1 transcription. This restrictive activity of Per-1 to HIV-1 replication may contribute to HIV-1 latency in resting CD4+ T-cells.
Our findings suggest a putative over-representation of PER3 polymorphisms in bipolar patients with alcohol abuse.
the strongest correlation was found between a decrease in placental PER1 expression and increased anxiety scores. Labour status was found to have a profound effect on mRNA expression.
TNPO1-mediated nuclear import may constitute a novel input pathway of how cellular redox state signals to the clock, since redox stress increases binding of TNPO1 to PER1 and decreases its nuclear localization. TNPO1 is one of the novel players essential for normal circadian periods and potentially for redox regulation of the clock.
the role of PER1 in carcinogenesis is exerted not only by regulating downstream genes, but also through the synergistic dysregulation of many other clock genes in the clock gene network.
Per1 is regulated by microRNA-34a, a small non-coding RNA that directly binds to genes and inhibit gene expression.
Low PER1 expression is associated with oral squamous cell carcinoma.
Low Per1 gene expression is associated with colorectal liver metastases.
The PER1 c.2884C > G polymorphism and PER3 54bp VNTR were associated with annual percent changes in bone mineral density of femoral neck after 1 year of hormone therapy. PER1 c.2884C > G polymorphism may be associated with risk of non-response to HT in postmenopausal Korean women.
ARNTL and PER1 were associated with PD.
Collectively, these data show that KPNB1 is required for timely nuclear import of PER/CRY in the negative feedback regulation of the circadian clock.
when overexpressed, c-MYC is able to repress Per1 transactivation by BMAL1/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC was detected in BMAL1 protein complexes
Period 1 and estrogen receptor-beta are downregulated in Chinese colon cancers.
Data demonstrate a role for Per1 in the transcriptional regulation of NHE3 and SGLT1 in the kidney.
In adipose tissue, acute sleep deprivation vs sleep increased methylation in two promoter-interacting enhancer regions of PER1
In patients with non-small cell lung cancer, loss of Per1 was correlated with poor differentiation, tumor status, high p-TNM stage and lymph node metastasis. Patients with lower expression of Per1, Per2 and Per3 had a shorter survival time.
S714G mutation in hPER1 is associated with feeding rhythms and obesity in mice.
The PER1 c.2247C> T and c.2884C> G polymorphisms singly and in combination were found to be related to the lumbar spine bone mineral density in postmenopausal Korean women.
Functional SNPs found in PER1 were significantly associated with recurrence-free survival in a Chinese population with hepatocellular carcinoma.
Fourteen proteins were identified to interact with per1 in tumor.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene\; however, these variants have not been fully described.
, period homolog 1
, circadian clock protein PERIOD 1
, circadian pacemaker protein Rigui
, period circadian protein homolog 1
, Period, drosophila, homolog of
, circadian pacemaker protein RIGUI