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Human Polyclonal PER1 Primary Antibody pour WB - ABIN1536671
Hwang-Verslues, Chang, Jeng, Kuo, Chiang, Chang, Hsieh, Su, Lin, Abbondante, Yang, Hsu, Yu, Chang, Shew, Lee, Lee: Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. dans Proceedings of the National Academy of Sciences of the United States of America 2013
Results show that Per1 expression is associated with a short period and Per2 (Montrer PER2 Anticorps) expression is associated with a long period and, that Per1 and Per2 (Montrer PER2 Anticorps) cooperatively confine the range of circadian period length to approximately 24-h.
This vitro data suggests that basal activity of autophagy seems to be modulated by PER1, and confirms the in vivo data by showing that the autophagic machinery is depressed in Per1-/--hippocampal neurons.
These findings indicate that the expressions of two key clock genes, Per1 and Bmal1 (Montrer ARNTL Anticorps), in the SCN (Montrer SRI Anticorps) are regulated in such a way that they may adopt different phases and free-running periods relative to each other and are respectively associated with the expression of activity onset and offset.
Atxn2 (Montrer ATXN2 Anticorps)(-/-) mice showed an unstable rhythmicity of locomotor activity, but the level of PER1 and PER2 (Montrer PER2 Anticorps) IR in the SCN (Montrer SRI Anticorps) did not differ between genotypes.
In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1(-/-) ) mice (right) the kinase is trapped at the nuclear periphery
beta-amyloid protein (31-35) altered the expression of the Per1 and Per2 in the suprachiasmatic nucleus, hippocampus and heart. These findings provide experimental evidence for circadian rhythm disturbances in patients with Alzheimer's disease.
In vivo knockdown of Rfk (Montrer RFK Anticorps), Riboflavin (vitamin B2) kinase essential for FAD (Montrer FANCD2 Anticorps) synthesis, altered the expression rhythms of CRY1 (Montrer CRY1 Anticorps), CRY2 (Montrer CRY2 Anticorps), and PER1
these data support an important role for the circadian clock protein (Montrer ARNTL Anticorps) PER1 in the modulation of blood pressure in a high salt/mineralocorticoid model of hypertension
Per1 knockdown leads to JNK (Montrer MAPK8 Anticorps) phosphorylation, CCL2 (Montrer CCL2 Anticorps) production and allodynia.
Deletion of Per1 alleviated the inhibitory effect of PPAR-gamma (Montrer PPARG Anticorps) on CC chemokine receptor 2 (Montrer CCRL2 Anticorps) expression, resulting in enhanced macrophage recruitment into the liver.
TNPO1 (Montrer TNPO1 Anticorps)-mediated nuclear import may constitute a novel input pathway of how cellular redox state signals to the clock, since redox stress increases binding of TNPO1 (Montrer TNPO1 Anticorps) to PER1 and decreases its nuclear localization. TNPO1 (Montrer TNPO1 Anticorps) is one of the novel players essential for normal circadian periods and potentially for redox regulation of the clock.
the role of PER1 in carcinogenesis is exerted not only by regulating downstream genes, but also through the synergistic dysregulation of many other clock genes in the clock gene network.
Per1 is regulated by microRNA-34a, a small non-coding RNA that directly binds to genes and inhibit gene expression.
Low PER1 expression is associated with oral squamous cell carcinoma.
Low Per1 gene expression is associated with colorectal liver metastases.
The PER1 c.2884C > G polymorphism and PER3 54bp VNTR were associated with annual percent changes in bone mineral density of femoral neck after 1 year of hormone therapy. PER1 c.2884C > G polymorphism may be associated with risk of non-response to HT in postmenopausal Korean women.
ARNTL (Montrer ARNTL Anticorps) and PER1 were associated with PD.
Collectively, these data show that KPNB1 (Montrer KPNB1 Anticorps) is required for timely nuclear import of PER/CRY (Montrer CRY2 Anticorps) in the negative feedback regulation of the circadian clock.
when overexpressed, c-MYC (Montrer MYC Anticorps) is able to repress Per1 transactivation by BMAL1 (Montrer ARNTL Anticorps)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (Montrer MYC Anticorps) was detected in BMAL1 (Montrer ARNTL Anticorps) protein complexes
Period 1 and estrogen receptor-beta (Montrer ESR2 Anticorps) are downregulated in Chinese colon cancers.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene\; however, these variants have not been fully described.
, period homolog 1
, circadian clock protein PERIOD 1
, circadian pacemaker protein Rigui
, period circadian protein homolog 1
, Period, drosophila, homolog of
, circadian pacemaker protein RIGUI